On generalizations of Fatou's theorem for the integrals with general kernels

We define $\lambda(r)$-convergence, which is a generalization of nontangential convergence in the unit disc. We prove Fatou-type theorems on almost everywhere nontangential convergence of Poisson-Stiltjes integrals for general kernels $\{\varphi_r\}$, forming an approximation of identity. We prove that the bound \md0 \limsup_{r\to 1}\lambda(r) \|\varphi_r\|_\infty<\infty \emd is necessary and sufficient for almost everywhere $\lambda(r)$-convergence of the integrals \md0 \int_\ZT \varphi_r(t-x)d\mu(t). \emdComment: 14 page

Non-specific LTD at parallel fibre - Purkinje cell synapses in cerebellar cortex provides robustness against local spatial noise during pattern recognition

© 2011 Safaryan et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedPoster presented at CNS 2011Peer reviewe

INFLUENCE OF HYDROGEN TREATMENT ON STRUCTURE AND PROPERTIES OF Zr-2,5Nb ZIRCONIUM ALLOY

В работе исследованы закономерности влияния дополнительного легирования водородом и термического воздействия на формирование фазового состава, структуры и твердость циркониевого сплава Zr-2,5Nb.The influence of additional hydrogen alloying and thermal treatment on the formation of phase composition, structure and hardness of Zr-2,5Nb zirconium alloy was investigated

Candidate genes for productivity identified by genome-wide association study with indicators of class in the Russian meat merino sheep breed

Genome-wide association studies allow identification of loci and polymorphisms associated with the formation of relevant phenotypes. When conducting a full genome analysis of sheep, particularly promising is the study of individuals with outstanding productivity indicators – exhibition animals, representatives of the super-elite class. The aim of this study was to identify new candidate genes for economically valuable traits based on the search for single nucleotide polymorphisms (SNPs) associated with belonging to different evaluation classes in rams of the Russian meat merino breed. Animal genotyping was performed using Ovine Infinium HD BeadChip 600K DNA, association search was performed using PLINK v. 1.07 software. Highly reliable associations were found between animals belonging to different evaluation classes and the frequency of occurrence of individual SNPs on chromosomes 2, 6, 10, 13, and 20. Most of the substitutions with high association reliability are concentrated on chromosome 10 in the region 10: 30859297–31873769. To search for candidate genes, 15 polymorphisms with the highest association reliability were selected (–log10(р) &gt; 9). Determining the location of the analyzed SNPs relative to the latest annotation Oar_rambouillet_v1.0 allowed to identify 11 candidate genes presumably associated with the formation of a complex of phenotypic traits of animals in the exhibition group: RXFP2, ALOX5AP, MEDAG, OPN5, PRDM5, PTPRT, TRNAS-GGA, EEF1A1, FRY, ZBTB21-like, and B3GLCT-like. The listed genes encode proteins involved in the control of the cell cycle and DNA replication, regulation of cell proliferation and apoptosis, lipid and carbohydrate metabolism, the development of the inflammatory process and the work of circadian rhythms. Thus, the candidate genes under consideration can influence the formation of exterior features and productive qualities of sheep. However, further research is needed to confirm the influence of genes and determine the exact mechanisms for implementing this influence on the phenotype

Uric Acid as a Risk Factor for Cardiovascular Diseases

Recently, hyperuricemia and its association with cardiovascular disease have been receiving more and more attention. The article talks about the role of uric acid in the body, the reasons for its increase and the impact of elevated uric acid levels on the cardiovascular system. The mechanisms of influence of hyperuricemia on the development and progression of cardiovascular diseases are presented. Medicinal and non-drug ways to reduce the level of uric acid in the blood are considered. From non-drug methods, attention is focused on the hypopurine diet, adequate drinking regimen and normalization of body weight. Separately, the effect on the level of uric acid of various drugs used in clinical practice is considered. In the light of current clinical guidelines, the issue of the need to prescribe drug therapy for asymptomatic hyperuricemia is discussed

The effect of non-specific LTD on pattern recognition in cerebellar Purkinje cells

© 2010 Safaryan et al; licensee BioMed Central Ltd.Poster presented at CNS 2010Peer reviewe

THE INFLUENCE OF HYDROGEN ALLOYING ON THE STRUCTURE, PHASE COMPOSITION AND TECHNOLOGICAL PLASTICITY OF THE TITANIUM ALLOY WITH ALUMINUM CONTENT EXCEEDING LIMIT SOLUBILITYABSTRACT

Установлено влияние водорода на структуру, фазовый состав и сопротивление горячей пластической деформации опытного сплава Ti–8,7Al–1,5Zr–2Mo, перспективного для изготовления силовых режущих хирургических инструментов. Установлено, что легирование водородом до 0,3 и 0,6 масс. % увеличивает объемную долю β-фазы при температурах α+α2+β-области и снижает предел текучести сплава на 115–200 МПа при температурах деформации 800–850С.The influence of hydrogen on the structure, phase composition and resistance of hot plastic deformation of the Ti–8.7Al–1.5Zr–2Moexperimental alloy, promising for the manufacture of power cutting surgical instruments, is established. It was found that doping with hydrogen to 0.3 and 0.6 wt. % increases the volume fraction of the β-phase at temperatures α+α2+β-region and reduces the yield strength of the alloy by 115–200 MPa at deformation temperatures of 800–850°C

LIPID-LOWERING THERAPY IN OUTPATIENT PRACTICE (ACCORDING TO THE ARGO-2 STUDY)

Aim. To study the features of lipid-lowering therapy with rosuvastatin in high and very high cardiovascular risk patients in real outpatient practice.Material and methods. Patients ≥30 years, visited internists or cardiologists of district outpatient clinics in the period from October 2013 to July 2014 were included into the study. Each patient fill in questionnaire. Determination of total cholesterol (TC) level was performed without special preparation of the patient using a portable photometric blood analyzer. Doctors prescribed rosuvastatin therapy when indicated, in accordance with the Guidelines, choosing the dose on their own. Repeated TC level was determined after 1 month.Results. TC level was initially determined in 10547 patients. Rosuvastatin treatment was recommended for all patients. Repeated TC level determination was performed in 7897 patients in an average after 33 days. Baseline TC level in them was 6.37±0.89 mmol/l, and after 1 month while taking rosuvastatin – 4.89±0.81 mmol/l (p&lt;0.001). The change of TC level was -22% (p&lt;0.001). The average prescribed dose of rosuvastatin was 11.88±5.1 mg per day. The most often (62.8%) rosuvastatin was prescribed in a dose of 10 mg per day, in 27.3% of patients – 20 mg per day, in 9.2% – 5 mg per day, and only 0.5% of patients took it in the maximal dose.Conclusion. In real clinical practice, rosuvastatin for treatment of patients with high or very high cardiovascular risk is often prescribed in moderate doses and rarely in the maximum dose despite the proven lipid-lowering effect