Pinning and collective modes of a vortex lattice in a Bose-Einstein condensate

We consider the ground state of vortices in a rotating Bose-Einstein condensate that is loaded in a corotating two-dimensional optical lattice. Due to the competition between vortex interactions and their potential energy, the vortices arrange themselves in various patterns, depending on the strength of the optical potential and the vortex density. We outline a method to determine the phase diagram for arbitrary vortex filling factor. Using this method, we discuss several filling factors explicitly. For increasing strength of the optical lattice, the system exhibits a transition from the unpinned hexagonal lattice to a lattice structure where all the vortices are pinned by the optical lattice. The geometry of this fully pinned vortex lattice depends on the filling factor and is either square or triangular. For some filling factors there is an intermediate half-pinned phase where only half of the vortices is pinned. We also consider the case of a two-component Bose-Einstein condensate, where the possible coexistence of the above-mentioned phases further enriches the phase diagram. In addition, we calculate the dispersion of the low-lying collective modes of the vortex lattice and find that, depending on the structure of the ground state, they can be gapped or gapless. Moreover, in the half-pinned and fully pinned phases, the collective mode dispersion is anisotropic. Possible experiments to probe the collective mode spectrum, and in particular the gap, are suggested.Comment: 29 pages, 4 figures, changes in section

Kinetic limitations of cooperativity based drug delivery systems

We study theoretically a novel drug delivery system that utilizes the overexpression of certain proteins in cancerous cells for cell specific chemotherapy. The system consists of dendrimers conjugated with "keys" (ex: folic acid) which "key-lock" bind to particular cell membrane proteins (ex: folate receptor). The increased concentration of "locks" on the surface leads to a longer residence time for the dendrimer and greater incorporation into the cell. Cooperative binding of the nanocomplexes leads to an enhancement of cell specificity. However, both our theory and detailed analysis of in-vitro experiments indicate that the degree of cooperativity is kinetically limited. We demonstrate that cooperativity and hence the specificity to particular cell type can be increased by making the strength of individual bonds weaker, and suggest a particular implementation of this idea. The implications of the work for optimizing the design of drug delivery vehicles are discussed.Comment: 4 pages, 4 figures, v3: minor revision