16 research outputs found

    Retrieval Practice as Process in Self-Directed Learning: New Philosophical Directions for Self-Directed Learning

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    We explain retrieval practice and its potential benefits for adult self-directed learners. Moreover, we argue functional contextualism as an alternative research philosophy to self-directed learning’s humanist assumptions

    Neutron Imaging Investigations of the Secondary Hydriding of Nuclear Fuel Cladding Alloys during Loss of Coolant Accidents

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    The hydrogen concentration and distribution at both sides of the burst opening of cladding tubes used in three QUENCH LOCA simulation bundle experiments were investigated by means of neutron radiography and tomography. The quantitative correlation between the total macroscopic neutron cross section and the atomic number density ratio between hydrogen and zirconium was determined by testing calibration specimens with known hydrogen concentrations. Hydrogen enrichments located at the end of the ballooning zone of the tested tubes were detected in the inner rods of the test bundles. Nearly all of the peripheral claddings exposed to lower temperatures do not show such enrichments. This implies that under the conditions investigated a threshold temperature exists below which no hydrogen enrichments can be formed. In order to understand the hydrogen distribution a model was developed describing the processes occurring during loss of coolant accidents after rod burst. The general shape of the hydrogen distributions with a peak each side of the ballooning region is well predicted by this model whereas the absolute concentrations are underestimated compared to the results of the neutron tomography investigations. The model was also used to discuss the influence of the alloy composition on the secondary hydrogenation. Whereas the relations for the maximal hydrogen concentrations agree well for one and the same alloy, the agreement for tests with different alloys is less satisfying, showing that material parameters such as oxidation kinetics, phase transition temperature for the zirconium oxide, and yield strength and ductility at high temperature have to be taken into account to reproduce the results of neutron imaging investigations correctl

    Supportive development of functional tissues for biomedical research using the MINUSHEET(R) perfusion system

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    Functional tissues generated under in vitro conditions are urgently needed in biomedical research. However, the engineering of tissues is rather difficult, since their development is influenced by numerous parameters. In consequence, a versatile culture system was developed to respond the unmet needs.Optimal adhesion for cells in this system is reached by the selection of individual biomaterials. To protect cells during handling and culture, the biomaterial is mounted onto a MINUSHEET(R) tissue carrier. While adherence of cells takes place in the static environment of a 24 well culture plate, generation of tissues is accomplished in one of several available perfusion culture containers. In the basic version a continuous flow of always fresh culture medium is provided to the developing tissue. In a gradient perfusion culture container epithelia are exposed to different fluids at the luminal and basal sides. Another special container with a transparent lid and base enables microscopic visualization of ongoing tissue development. A further container exhibits a flexible silicone lid to apply force onto the developing tissue thereby mimicking mechanical load that is required for developing connective and muscular tissue. Finally, stem/progenitor cells are kept at the interface of an artificial polyester interstitium within a perfusion culture container offering for example an optimal environment for the spatial development of renal tubules.The system presented here was evaluated by various research groups. As a result a variety of publications including most interesting applications were published. In the present paper these data were reviewed and analyzed. All of the results point out that the cell biological profile of engineered tissues can be strongly improved, when the introduced perfusion culture technique is applied in combination with specific biomaterials supporting primary adhesion of cells
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