Stability Analysis of a Hybrid Cellular Automaton Model of Cell Colony Growth

Cell colonies of bacteria, tumour cells and fungi, under nutrient limited growth conditions, exhibit complex branched growth patterns. In order to investigate this phenomenon we present a simple hybrid cellular automaton model of cell colony growth. In the model the growth of the colony is limited by a nutrient that is consumed by the cells and which inhibits cell division if it falls below a certain threshold. Using this model we have investigated how the nutrient consumption rate of the cells affects the growth dynamics of the colony. We found that for low consumption rates the colony takes on a Eden-like morphology, while for higher consumption rates the morphology of the colony is branched with a fractal geometry. These findings are in agreement with previous results, but the simplicity of the model presented here allows for a linear stability analysis of the system. By observing that the local growth of the colony is proportional to the flux of the nutrient we derive an approximate dispersion relation for the growth of the colony interface. This dispersion relation shows that the stability of the growth depends on how far the nutrient penetrates into the colony. For low nutrient consumption rates the penetration distance is large, which stabilises the growth, while for high consumption rates the penetration distance is small, which leads to unstable branched growth. When the penetration distance vanishes the dispersion relation is reduced to the one describing Laplacian growth without ultra-violet regularisation. The dispersion relation was verified by measuring how the average branch width depends on the consumption rate of the cells and shows good agreement between theory and simulations.Comment: 8 pages, 6 figure

Pneumocephalus Following Unidentified Dural Puncture: A Case Report with an Unusual Neurological Presentation

Pneumocephalus is a rare consequence of epidural anesthesia, which may occur following inadvertent or unidentified dural puncture when the loss of resistance to air technique is applied to identify the epidural space. Headache is the most common symptom presented in this condition, usually with sudden onset. This case report describes an unusual presentation of diffuse pneumocephalus after an unidentified dural puncture. The patient (male, 67 years old) was submitted to epidural catheter placement for the treatment of acute exacerbation of ischemic chronic pain using loss of resistance to air technique. No cerebrospinal fluid or blood flashback was observed after needle withdrawal. Shortly after the intervention, the patient presented symptoms of lethargy, apathy, and hypophonia, which are not commonly associated with pneumocephalus. No motor or sensory deficits were detected. Cranial computed tomography showed air in the frontal horn of the left ventricle, subarachnoid space at interhemispheric fissure and basal cisterns, confirming the diagnosis of diffuse pneumocephalus. The patient remained under vigilance with oxygen therapy and the epidural catheter left in place. After 24 hours, cranial computed tomography showed air in the temporal and frontal horns of the left ventricle, with no air in the subarachnoid space. The patient presented no neurological signs or symptoms at this time. Although headache is the most common symptom presented in reported cases of pneumocephalus, this case shows the need for the clinician to be aware of other signs and symptoms that may be indicative of this condition, in order to properly diagnose and treat these patients.info:eu-repo/semantics/publishedVersio

Poderemos encontrar factores preditivos de vómitos no pós-operatório de cirurgia em regime de ambulatório?

Abstract A retrospective analyses of patients submitted to surgery on a day basis was made through our database. The goal of the study was to identify risk factors of postoperative vomiting associated to day surgery. 2115 patients operated between January 2003 and November 2004 on our day surgery unit were included. 70 patients (3,3%) suffered at least on episode of postoperative vomiting. Several factors were analysed: age, sex, surgical speciality, ASA physical status, anaesthetic technique and the duration of anesthesia. Chi-Square Test was used for testing each factor individually. Differences were considered significant when p <0,05. Logistic regression was then used to identify the multivariate association strength of these factors. The female sex (Odds ratio =4,94) and the duration of anesthesia when longer than 180 minutes (Odds ratio =8,13), had been associated to a higher incidence of postoperative vomiting, while loco-regional technique (Odds ratio = 0,15) and sedation with local anaesthesia (Odds ratio =0,09) had been associated with a lower incidence. Authors evidence the importance of the identification of postoperative vomiting risk factors that will allow us to establish better guidelines on postoperative nausea and vomiting prophylaxis in these patients and to improve the quality of our clinical care and the satisfaction of our patients. Através da análise do registo informatizado de dados dos doentes operados em regime de ambulatório, os autores procuraram identificar factores de risco que se encontrassem associados a uma maior incidência de vómitos no pós-operatório (VPO). Incluíram-se 2115 doentes submetidos a cirurgia entre Janeiro de 2003 e Novembro de 2004, tendo 70 doentes sofrido pelo menos um episódio de VPO (3,3%). Foram consideradas variáveis a analisar, a idade, o sexo, a especialidade cirúrgica, o estado físico (ASA), a técnica anestésica e a duração da anestesia. Procedeu-se à análise estatística de cada factor individualmente através da aplicação do χ2, seguindo-se a utilização de uma regressão logística para identificar a força de associação multivariável desses factores. O sexo feminino (Odds ratio =4,94) e a duração da anestesia quando superior a 180 minutos (OR =8,13), associaram-se a uma maior incidência de VPO enquanto a técnica loco-regional (OR =0,15) e a sedação com anestesia local (OR =0,09) se associaram a uma menor incidência daqueles. Os autores evidenciam a importância deste tipo de trabalhos na identificação de factores de risco que possam levar à criação de escalas de risco que orientem com maior racionalidade económica, a intervenção terapêutica profiláctica das náuseas e vómitos no pós-operatório

Virtualization of pliocene sites in the Huelva province: valuating the paleontological heritage in differentiate educative settings I

El patrimonio paleontológico del Plioceno de la provincia de Huelva es uno de los más importantes de España y referente europeo de moluscos de este período. Sin embargo, no existe un inventario de catalogación básica de los principales yacimientos ni de los principales grupos fósiles presentes, así como de su importancia como patrimonio natural. El presente trabajo pretende rellenar este notable vacío con una proyección tanto hacia materias preuniversitarias como universitarias, así como hacia posibles instituciones y corporaciones públicas susceptibles de utilizarlo en sus planes de ordenación. Por otro lado, se pretende que actúe como mecanismo de interconexión entre titulaciones con bajo número de alumnos de nuevo ingreso y los centros de Bachillerato, de forma que incentive una posible elección de estos Grados por los alumnos de las opciones científico-tecnológicas. También puede ser interesante para captar egresados hacia Másteres Oficiales en Patrimonio Histórico y Natural. En este sentido, se ha realizado un DVD documental sobre el patrimonio paleontológico del Plioceno de la provincia de Huelva, concretamente de las formaciones “Arenas de Huelva” y “Arenas de Bonares” desarrolladas en ambientes marinos someros y costeros durante la última etapa de evolución neógena de la cuenca. Este documental incluye una visión de conjunto de los principales yacimientos fósiles de esta edad, así como una explicación de la evolución paleogeográfica de nuestra provincia y los organismos que la han caracterizado en los últimos millones de años. Esta aportación es aplicable en el trabajo de campo de varios Grados y Posgrados universitarios y de fácil uso como material didáctico en diversas asignaturas de E.S.O. y Bachillerato. Este trabajo se ha realizado en el marco del proyecto de innovación docente (PID nº 10050) de la Universidad de Huelva.The paleontological heritage from the Neogene in the province of Huelva is one of the most important in Spain and it is considered a European reference site for the mollusk fossil record from this period. However, there are not basic inventories neither for the main sites nor the major fossil groups. Furthermore, no inventories exist about their natural heritage importance. This work aims to fill this significant gap for both pre-university and university levels, as well as to public institutions and corporations that may use it in their management plans. In addition, it is intended to act as an linking mechanism between university degrees with low number of first-year students and high school centres, in order to encourage a possible choice of these Bachelor’s degrees by scientific and technological students. It may also be interesting to catch the attention of graduates for Official Masters in Historical and Natural Heritage. In this sense, a DVD-documentary has been made about the paleontological heritage from the Pliocene in the province of Huelva, specifically from the “Arenas de Huelva” and “Arenas de Bonares” formations. These units were developed in shallow marine and coastal environments during the last stage of the Neogene evolution in the Guadalquivir Basin. This documental includes an overview of main marine fossil sites from this age and a brief explanation of the palaeogeographic evolution of the Huelva province during the last million of years. This contribution is useful for the fieldwork at Bachelor and Master Degree level and it is easy to use as teaching materials in different ESO (Obligatory Secondary Teaching) and High School subjects. This work has been support for an Innovation in Teaching Project (PID No. 10050) of the Huelva University

Quantum Noise and Polarization Fluctuations in Vertical Cavity Surface Emitting Lasers

We investigate the polarization fluctuations caused by quantum noise in quantum well vertical cavity surface emitting lasers (VCSELs). Langevin equations are derived on the basis of a generalized rate equation model in which the influence of competing gain-loss and frequency anisotropies is included. This reveals how the anisotropies and the quantum well confinement effects shape the correlations and the magnitude of fluctuations in ellipticity and in polarization direction. According to our results all parameters used in the rate equations may be obtained experimentally from precise time resolved measurements of the intensity and polarization fluctuations in the emitted laser light. To clarify the effects of anisotropies and of quantum well confinement on the laser process in VCSELs we therefore propose time resolved measurements of the polarization fluctuations in the laser light. In particular, such measurements allow to distinguish the effects of frequency anisotropy and of gain-loss anisotropy and would provide data on the spin relaxation rate in the quantum well structure during cw operation as well as representing a new way of experimentally determinig the linewidth enhancement factor alpha.Comment: 16 pages and 3 Figures, RevTex, to be published in Phys. Rev.

Quantum Maxwell-Bloch equations for spatially inhomogeneous semiconductor lasers

We present quantum Maxwell-Bloch equations (QMBE) for spatially inhomogeneous semiconductor laser devices. The QMBE are derived from fully quantum mechanical operator dynamics describing the interaction of the light field with the quantum states of the electrons and the holes near the band gap. By taking into account field-field correlations and field-dipole correlations, the QMBE include quantum noise effects which cause spontaneous emission and amplified spontaneous emission. In particular, the source of spontaneous emission is obtained by factorizing the dipole-dipole correlations into a product of electron and hole densities. The QMBE are formulated for general devices, for edge emitting lasers and for vertical cavity surface emitting lasers, providing a starting point for the detailed analysis of spatial coherence in the near field and far field patterns of such laser diodes. Analytical expressions are given for the spectra of gain and spontaneous emission described by the QMBE. These results are applied to the case of a broad area laser, for which the frequency and carrier density dependent spontaneous emission factor beta and the evolution of the far field pattern near threshold are derived.Comment: 22 pages RevTex and 7 figures, submitted to Phys.Rev.A, revisions in abstract and in the discussion of temporal coherenc

Micelle formation, gelation and phase separation of amphiphilic multiblock copolymers

The phase behaviour of amphiphilic multiblock copolymers with a large number of blocks in semidilute solutions is studied by lattice Monte Carlo simulations. The influence on the resulting structures of the concentration, the solvent quality and the ratio of hydrophobic to hydrophilic monomers in the chains has been assessed explicitely. Several distinct regimes are put in evidence. For poorly substituted (mainly hydrophilic) copolymers formation of micelles is observed, either isolated or connected by the hydrophilic moieties, depending on concentration and chain length. For more highly substituted chains larger tubular hydrophobic structures appear which, at higher concentration, join to form extended hydrophobic cores. For both substitution ratios gelation is observed, but with a very different gel network structure. For the poorly substituted chains the gel consists of micelles cross-linked by hydrophilic blocks whereas for the highly substituted copolymers the extended hydrophobic cores form the gelling network. The interplay between gelation and phase separation clearly appears in the phase diagram. In particular, for poorly substituted copolymers and in a narrow concentration range, we observe a sol-gel transition followed by an inverse gel-sol transition when increasing the interaction energy. The simulation results are discussed in the context of the experimentally observed phase properties of methylcellulose, a hydrophobically substituted polysaccharide.Comment: 14 pages, 14 figures; Soft Matter (2011

Los Rajiformes (Chondrichthyes, Batomorphii) del Plioceno inferior de la Formación Arenas de Huelva, suroeste de España

EL Neógeno marino del suroeste de España ha sido objeto de numerosos estudios, su contenido fosilífero ha sido objeto de numerosos trabajos, abordando diferentes grupos como malacofauna (Andrés, 1982; González-Delgado, 1983), foraminíferos (Sierro, 1984; González-Regalado, 1986), nanoplancton calcáreo (Flores, 1985), ostrácodos (González-Regalado y Ruiz, 1990, 1991; Ruiz y González-Regalado, 1996), polen (Valle y Peñalba, 1987), así como aspectos generales de tafonomía y paleoecología (Mayoral, 1986) y vertebrados (Ruiz et al., 1997). Algunos de estos trabajos indicaban la presencia de restos ictiológicos, como dientes de seláceos y otolitos. En este trabajo se presentan los registros inéditos de los Rajiformes de Formación Arenas de Huelva, Provincia de Huelva, España (Fig. 1) de la tesis doctoral de García (2008)

Deterministic polarization chaos from a laser diode

Fifty years after the invention of the laser diode and fourty years after the report of the butterfly effect - i.e. the unpredictability of deterministic chaos, it is said that a laser diode behaves like a damped nonlinear oscillator. Hence no chaos can be generated unless with additional forcing or parameter modulation. Here we report the first counter-example of a free-running laser diode generating chaos. The underlying physics is a nonlinear coupling between two elliptically polarized modes in a vertical-cavity surface-emitting laser. We identify chaos in experimental time-series and show theoretically the bifurcations leading to single- and double-scroll attractors with characteristics similar to Lorenz chaos. The reported polarization chaos resembles at first sight a noise-driven mode hopping but shows opposite statistical properties. Our findings open up new research areas that combine the high speed performances of microcavity lasers with controllable and integrated sources of optical chaos.Comment: 13 pages, 5 figure

Virtualization of niebla formation sites (upper miocene) in the Huelva province: valuating the paleontological heritage in differentiate educative settings II

El patrimonio paleontológico del Neógeno de la provincia de Huelva es uno de los más importantes de España y referente europeo de moluscos de este período. Sin embargo, no existe un inventario de catalogación básica de los principales yacimientos ni de los principales grupos fósiles presentes, así como de su importancia como patrimonio natural. El presente trabajo pretende rellenar este notable vacío con una proyección tanto hacia materias preuniversitarias como universitarias, así como hacia posibles instituciones y corporaciones públicas susceptibles de utilizarlo en sus planes de ordenación. Por otro lado, se pretende que actúe como mecanismo de interconexión entre titulaciones con bajo número de alumnos de nuevo ingreso y los centros de Bachillerato, de forma que incentive una posible elección de estos Grados por los alumnos de las opciones científico-tecnológicas. También puede ser interesante para captar egresados hacia Másteres Oficiales en Patrimonio Histórico y Natural. En este sentido, se ha realizado un DVD documental sobre el patrimonio paleontológico del Mioceno superior de la provincia de Huelva. Este documental incluye una visión de conjunto de los principales yacimientos de fósiles marinos de la Fm. Niebla, desarrollada en un marco transgresivo bajo unas condiciones más húmedas y cálidas que las actuales. Esta aportación es aplicable al trabajo de campo de varios Grados y Posgrados universitarios y de fácil uso como material didáctico en diversas asignaturas de E.S.O. y Bachillerato. Este trabajo se ha realizado en el marco del proyecto de innovación docente (PID nº 11003) de la Universidad de Huelva.The paleontological heritage from the Neogene in the province of Huelva is one of the most important in Spain and it is considered a European reference site for the mollusk fossil record from this period. However, there are not basic inventories neither for the main sites nor the major fossil groups. Furthermore, no inventories exist about their natural heritage importance. This work aims to fill this significant gap for both pre-university and university levels, as well as to public institutions and corporations that may use it in their management plans. In addition, it is intended to act as an linking mechanism between university degrees with low number of first-year students and high school centres, in order to encourage a possible choice of these Bachelor’s degrees by scientific and technological students. It may also be interesting to catch the attention of graduates for Official Masters in Historical and Natural Heritage. In this sense, a DVD-documentary has been made about the paleontological heritage from the Upper Miocene in the province of Huelva. This documental includes an overview of the main marine fossil sites from the Niebla Formation developed in a transgressive setting under more humid and warmer conditions than today. This contribution is useful for the fieldwork at Bachelor and Master Degree level and it is easy to use as teaching materials in different ESO (Obligatory Secondary Teaching) and High School subjects. This work has been funded for an Innovation in Teaching Project (PID No. 10050) of the Huelva University