Pressure dependence and non-universal effects of microscopic couplings on the spin-Peierls transition in CuGeO_3

The theory by Cross and Fisher (CF) is by now commonly accepted for the description of the spin-Peierls transition within an adiabatic approach. The dimerization susceptibility as the essential quantity, however, is approximated by means of a continuum description. Several important experimental observations can not be understood within this scope. Using density matrix renormalization group (DMRG) techniques we are able to treat the spin system exactly up to numerical inaccuracies. Thus we find the correct dependence of the equation of state on the spin-spin interaction constant J, still in an adiabatic approach. We focus on the pressure dependence of the critical temperature which is absent in the CF theory as the only energy scale with considerable pressure dependence is J which drops out completely. Comparing the theoretical findings to the experimentally measured pressure dependence of the spin-Peierls temperature we obtain information on the variation of the frustration parameter with pressure. Furthermore, the ratio of the spectral gap and the transition temperature is analyzed.Comment: 5 pages, 5 figures and 1 table include

Formation Time of a Fermion Pair Condensate

The formation time of a condensate of fermionic atom pairs close to a Feshbach resonance was studied. This was done using a phase-shift method in which the delayed response of the many-body system to a modulation of the interaction strength was recorded. The observable was the fraction of condensed molecules in the cloud after a rapid magnetic field ramp across the Feshbach resonance. The measured response time was slow compared to the rapid ramp, which provides final proof that the molecular condensates reflect the presence of fermion pair condensates before the ramp.Comment: 5 pages, 4 figure

Observation of Feshbach resonances between two different atomic species

We have observed three Feshbach resonances in collisions between lithium-6 and sodium-23 atoms. The resonances were identified as narrow loss features when the magnetic field was varied. The molecular states causing these resonances have been identified, and additional lithium-sodium resonances are predicted. These resonances will allow the study of degenerate Bose-Fermi mixtures with adjustable interactions, and could be used to generate ultracold heteronuclear molecules

Observation of Bose-Einstein Condensation of Molecules

We have observed Bose-Einstein condensation of molecules. When a spin mixture of fermionic Li-6 atoms was evaporatively cooled in an optical dipole trap near a Feshbach resonance, the atomic gas was converted into Li_2 molecules. Below 600 nK, a Bose-Einstein condensate of up to 900,000 molecules was identified by the sudden onset of a bimodal density distribution. This condensate realizes the limit of tightly bound fermion pairs in the crossover between BCS superfluidity and Bose-Einstein condensation.Comment: 4 pages, 3 figure

Evidence for Regulation ofECM3Expression by Methylation of Histone H3 Lysine 4 and Intergenic Transcription inSaccharomyces cerevisiae

Transcription of nonprotein-coding DNA is widespread in eukaryotes and plays important regulatory roles for many genes, including genes that are misregulated in cancer cells. Its pervasiveness presents the potential for a wealth of diverse regulatory roles for noncoding transcription. We previously showed that the act of transcribing noncoding DNA (ncDNA) across the promoter of the protein-coding SER3 gene in Saccharomyces cerevisiae positions nucleosomes over the upstream activating sequences, leading to strong repression of SER3 transcription. To explore the possibility of other regulatory roles for ncDNA transcription, we selected six candidate S. cerevisiae genes that express ncRNAs over their promoters and analyzed the regulation of one of these genes, ECM3, in detail. Because noncoding transcription can lead to changes in the local chromatin landscape that impinge on the expression of nearby coding genes, we surveyed the effects of various chromatin regulators on the expression of ECM3. These analyses identified roles for the Paf1 complex in positively regulating ECM3 transcription through methylation of histone H3 at lysine 4 (K4) and for Paf1 in controlling the pattern of intergenic transcription at this locus. By deleting a putative promoter for the noncoding transcription unit that lies upstream of ECM3, we provide evidence for a positive correlation between intergenic transcription and ECM3 expression. Our results are consistent with a model in which cotranscriptional methylation of histone H3 K4, mediated by the Paf1 complex and noncoding transcription, leads to activation of ECM3 transcription

Condensation of Pairs of Fermionic Atoms Near a Feshbach Resonance

We have observed Bose-Einstein condensation of pairs of fermionic atoms in an ultracold ^6Li gas at magnetic fields above a Feshbach resonance, where no stable ^6Li_2 molecules would exist in vacuum. We accurately determined the position of the resonance to be 822+-3 G. Molecular Bose-Einstein condensates were detected after a fast magnetic field ramp, which transferred pairs of atoms at close distances into bound molecules. Condensate fractions as high as 80% were obtained. The large condensate fractions are interpreted in terms of pre-existing molecules which are quasi-stable even above the two-body Feshbach resonance due to the presence of the degenerate Fermi gas.Comment: submitted to PRL. v3: clarifying revisions, added referenc

Structured Smoking Cessation Training for Medical Students: a prospective study

Introduction: Physician adherence to guideline recommendations regarding the provision of counseling and support for smokers willing to quit is low. A lack of training during undergraduate medical education has been identified as a potential cause. This prospective intervention study evaluated a novel teaching module for medical students. Methods: As part of a 6-week cardiovascular course, 125 fourth-year undergraduate medical students received a multimodal and interactive teaching module on smoking cessation, including online learning material, lectures, seminars, and practical skills training. Short- and medium-term effects on knowledge, skills, attitudes, and self-reported practice were measured using written examinations and an objective structured clinical examination at the end of the module and 6 months later. Results were compared to data obtained from a historical control cohort (n = 70) unexposed to the intervention. Results: At the 6-month follow-up, scores in the knowledge test were significantly higher in the intervention than the control group (61.1% vs. 51.7%; p < .001). A similar pattern was observed in the objective structured clinical examination (71.5% vs. 60.5%; p < .001). More students in the intervention than control group agreed that smoking was a chronic disease (83.1% vs. 68.1%; p = .045). The control group was more likely to report recording smoking status (p = .018), but no group difference was detected regarding the report of advising to quit (p = .154). Conclusions: A novel teaching module for undergraduate medical students produced a sustained learning outcome in terms of knowledge, skills, and attitudes but not self-reported practice. Implications: Studies across the world have identified considerable knowledge gaps and deficits in practical training with regard to smoking cessation counseling in undergraduate medical students. This paper describes a teaching intervention informed by current recommendations for the design of educational activities aimed at enabling medical students to deliver adequate behavior change counseling. The teaching module was tailored to the needs of a specific healthcare system. Given its effectiveness as demonstrated in this prospective study, a rollout of this intervention in medical schools might have the potential to substantially improve medical students’ knowledge, skills, and attitudes in relation to smoking cessation counseling

Search for proton decay in the Frejus experiment

The status of the Frejus experiment and the preliminary results obtained in the search for nucleon decay are discussed. A modular, fine grain tracking calorimeter was installed in the Frejus laboratory in the period extending from October 1983 to May 1985. The 3300 cubic meter underground laboratory, located in the center of the Frejus tunnel in the Alps, is covered in the vertical direction by 1600 m of rocks (4400 m w.e.). The average number of atmospheric muons in the lab is 4.2 square meters per day. The 912 ton detector is made of 114 modules, each one including eight flash chamber and one Geiger vertical planes of (6 x 6) square meters dimensions. The flash chamber (and Geiger) planes are alternatively crossed to provide a 90 deg. stereo reconstruction. No candidate for the nucleon decay into charged lepton is found in the first sample of events

Decrease in resting heart rate measured using smartphone apps to verify abstinence from smoking: an exploratory study

INTRODUCTION: Verifying self-reports of smoking abstinence is challenging in studies that involve remote data collection. Resting heart rate (HR) decreases during smoking abstinence. This study assessed whether a decrease in resting HR measured using freely available smartphone apps could potentially be used to verify smoking abstinence. METHODS: This study involved a repeated measures experimental design, with data collection in natural setting. Participants were 18 adult, daily smokers. They recorded resting HR in beats per minute (bpm) using freely available smartphone apps during five time points (two in the morning and three post-noon) on each of three days. The outcome measure was the mean of the post-noon HR recordings. The experimental condition for each of the three days (counterbalanced order) was: 1) smoking as usual, 2) not smoking without nicotine replacement therapy (NRT), or 3) not smoking but using NRT. Abstinence was verified using expired-air carbon monoxide (CO) concentration. RESULTS: Compared with the smoking as usual condition, mean HR was 13.4 bpm lower (95%CI=5.4-21.4,p=0.001) in the not smoking without NRT condition and 10.4 bpm lower (95%CI=3.1-17.8, p=0.004) in the not smoking with NRT condition. There was no statistically significant difference in HR between the two not smoking conditions (p=0.39). Abstinence during not smoking days without and with NRT was CO-verified in 18/18 and in 16/18 cases, respectively. CONCLUSIONS: Self-recording of resting heart rate in natural setting using smartphone apps shows a reliable decrease in response to smoking abstinence and may provide a basis for remote verification in smoking cessation studies. IMPLICATIONS: Remote verification of self-reported abstinence in smoking cessation studies remains challenging. Smoking abstinence has been shown to decrease resting heart rate under laboratory conditions. This study demonstrated that self-recording using freely available smartphone apps shows reliable decreases in resting heart rate during smoking abstinence and may provide a basis for inexpensive remote verification of smoking abstinence