Hot electrons in low-dimensional phonon systems

A simple bulk model of electron-phonon coupling in metals has been surprisingly successful in explaining experiments on metal films that actually involve surface- or other low-dimensional phonons. However, by an exact application of this standard model to a semi-infinite substrate with a free surface, making use of the actual vibrational modes of the substrate, we show that such agreement is fortuitous, and that the model actually predicts a low-temperature crossover from the familiar T^5 temperature dependence to a stronger T^6 log T scaling. Comparison with existing experiments suggests a widespread breakdown of the standard model of electron-phonon thermalization in metals

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo

Significance: Detection and characterization of circulating tumor cells (CTCs), a key determinant of metastasis, are critical for determining risk of disease progression, understanding metastatic pathways, and facilitating early clinical intervention. Aim: We aim to demonstrate label-free imaging of suspected melanoma CTCs. Approach: We use a linear-array-based photoacoustic tomography system (LA-PAT) to detect melanoma CTCs, quantify their contrast-to-noise ratios (CNRs), and measure their flow velocities in most of the superficial veins in humans. Results: With LA-PAT, we successfully imaged suspected melanoma CTCs in patients in vivo, with a CNR >9. CTCs were detected in 3 of 16 patients with stage III or IV melanoma. Among the three CTC-positive patients, two had disease progression; among the 13 CTC-negative patients, 4 showed disease progression. Conclusions: We suggest that LA-PAT can detect suspected melanoma CTCs in patients in vivo and has potential clinical applications for disease monitoring in melanoma

A novel spectral estimation method by using periodic nonuniform sampling

In this paper we present a method of estimating power spectrum density of random ergodic signals. The method allows use of arbitrarily low sampling rates to achieve the goal. We compare our method with similar schemes reported in research literature and argue superiority of our approach in terms of its suitability for practical implementations. The most visible difference between our approach and the previously reported ones consists in replacing Poisson additive random sampling with deterministic sampling. Comparing with the approaches based on the Poisson additive random sampling, where theoreticall infinitely large resources are needed to implement them accurately, our approach clearly relies on limited and well defined resources

Effects of reproductive and demographic changes on breast cancer incidence in China: A modeling analysis

Background: Breast cancer incidence is currently low in China. However, the distribution of reproductive and lifestyle risk factors for breast cancer among Chinese women is changing rapidly. We quantified the expected effect of changes in breast cancer risk factors on future rates of breast cancer in China. Methods: We first validated and calibrated the Rosner-Colditz log-incidence breast cancer model in Chinese women who participated in the Shanghai Women's Health Study cohort (N = 74 942). We then applied the calibrated model to a representative sample of Chinese women who were aged 35-49 years in 2001 using data from the Chinese National Family Planning and Reproductive Health Survey (NFPRHS, N = 17 078) to predict the age-specific and cumulative breast cancer incidence among all Chinese women of this age group. We evaluated the relative impact of changes in modifiable risk factors, including alcohol intake, parity, postmenopausal hormone use, and adult weight gain, on cumulative incidence of breast cancer. Results: Breast cancer incidence in China is expected to increase substantially from current rates, estimated at 10-60 cases per 100 000 women, to more than 100 new cases per 100 000 women aged 55-69 years by 2021. We predicted 2.5 million cases of breast cancer by 2021 among Chinese women who were 35-49 years old in 2001. Modest reductions in hormone and alcohol use, and weight maintenance could prevent 270 000 of these cases. Conclusions: China is on the cusp of a breast cancer epidemic. Although some risk factors associated with economic development are largely unavoidable, the substantial predicted increase in new cases of breast cancer calls for urgent incorporation of this disease in future health care infrastructure planning

Optimal periodic sampling sequences for nearly-alias-free digital signal processing

Alias-free DSP (DASP) is a methodology of processing signals digitally inside bandwidths that are wider than the famous Nyquist limit of half of the sampling requency. DASP is facilitated by suitable combination of nonuniform sampling and appropriate processing algorithms. In this paper we propose a new method of constructing sampling schemes for the needs of DASP. Unlike traditional approaches that rely on randomly selected sampling instants we use deterministic schemes. A method of optimizing such sequences aimed at minimization of aliasing is proposed. The approach is tested numerically in an experiment where an undersampled signal is processed using DASP; first to estimate the signal's spectrum support function and then the spectrum itself. We demonstrate advantages of the proposed approach over those that use random sampling

Self-organized criticality in the intermediate phase of rigidity percolation

Experimental results for covalent glasses have highlighted the existence of a new self-organized phase due to the tendency of glass networks to minimize internal stress. Recently, we have shown that an equilibrated self-organized two-dimensional lattice-based model also possesses an intermediate phase in which a percolating rigid cluster exists with a probability between zero and one, depending on the average coordination of the network. In this paper, we study the properties of this intermediate phase in more detail. We find that microscopic perturbations, such as the addition or removal of a single bond, can affect the rigidity of macroscopic regions of the network, in particular, creating or destroying percolation. This, together with a power-law distribution of rigid cluster sizes, suggests that the system is maintained in a critical state on the rigid/floppy boundary throughout the intermediate phase, a behavior similar to self-organized criticality, but, remarkably, in a thermodynamically equilibrated state. The distinction between percolating and non-percolating networks appears physically meaningless, even though the percolating cluster, when it exists, takes up a finite fraction of the network. We point out both similarities and differences between the intermediate phase and the critical point of ordinary percolation models without self-organization. Our results are consistent with an interpretation of recent experiments on the pressure dependence of Raman frequencies in chalcogenide glasses in terms of network homogeneity.Comment: 20 pages, 18 figure

Spin-momentum coupled Bose-Einstein condensates with lattice band pseudospins

The quantum emulation of spin-momentum coupling (SMC), a crucial ingredient for the emergence of topological phases, is currently drawing considerable interest. In previous quantum gas experiments, typically two atomic hyperfine states were chosen as pseudospins. Here, we report the observation of a new kind of SMC achieved by loading a Bose-Einstein condensate (BEC) into periodically driven optical lattices. The s- and p-bands of a static lattice, which act as pseudospins, are coupled through an additional moving lattice which induces a momentum dependent coupling between the two pseudospins, resulting in s-p hybrid Floquet-Bloch bands. We investigate the band structures by measuring the quasimomentum of the BEC for different velocities and strengths of the moving lattice and compare our measurements to theoretical predictions. The realization of SMC with lattice bands as pseudospins paves the way for engineering novel quantum matter using hybrid orbital bands.Comment: 6 pages, 5 figure