Cancer-Associated Thrombotic Microangiopathy: Literature Review and Report of Five Cases

Thrombotic microangiopathy (TMA) is an anatomopathological lesion mediated by endothelial dysfunction and characterized by the creation of microthrombi in small vessels. In patients with cancer, it may be due to toxicity secondary to chemotherapy, tumor embolization, or hematopoietic progenitor transplantation. Cancer-associated TMA is an underestimated entity that generally appears in the final stages of the disease, although it may also be the initial manifestation of an underlying cancer. Support treatment is necessary in all cases and, depending on the cause, different targeted therapies may be used. The prognosis is very poor. In this article we present a comprehensive review of the existing literature on the physiological mechanisms of cancer-associated TMA. Afterwards, five clinical cases will be presented of patients who developed TMA and were diagnosed in our Department in 2023. We present a discussion of the different causes that triggered the condition, the possible reasons behind the underestimation of this pathology, and the measures that may be adopted

Effect of electrolyzed water on ruminal fermentation in vitro using inoculum from forage-fed animals

3 páginas, 1 tabla.-- Trabajo presentado a las XV Jornadas sobre Producción Animal AIDA (Zaragoza, 14 al 15 de mayo, 2013).The effects of alkaline (Catolyte, pH 11,5) and slightly acidic (Anolyte, pH 7,0) electrolyzed water substituting 25 or 50% of distilled water in the culture medium for in vitro gas production technique were evaluated when using inocula from fistulated ewes fed on alfalfa hay., Two diets (alfalfa and concentrate) were incubated., When alfalfa was used as substrate, gas and AGV production and butyrate proportion decreased (P<0.,001) and acetate proportion increased (P<0.,001). Anolyte at 25 or 50% rates and Catolyte at 50% rate decreased gas production., Anolyte at 50% rate also decreased final pH, Volatile fatty acids production was not affected, but acetate proportion increased and butyrate proportion decreased when either Anolyte or Catolyte were used at 50% rate (P<0.,05)., Using high doses of electrolyzed water affects ruminal fermentation in vitro by reducing gas production and increasing acetate proportion. Anolyte tends to reduce ruminal pH.Proyecto financiado por el Instituto Tecnológico Agrario de Castilla y León (Consejería de Agricultura y Ganadería, Junta de Castilla y León) (Proyecto 2010- 1284) y Fondos FEDER.Peer reviewe

Integración de trabajos de investigación para la gestión sostenible de los pastos de montaña del Norte peninsular

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Desenvolvimento e desigualdades na América Latina : dilemas de longo curso

No início da terceira década do século XXI, o leitor é agraciado com uma obra coletiva de fôlego, inovadora, e certamente paradigmática. Estamos diante de um livro util para compreender e agir em favor do Desenvolvimento e, inversamente, para continuar lutando de forma mais eficiente contra o excesso de Desigualdade. Resta agradecer ao organizador do livro e aos autores de cada um dos capítulos pelo brilhante trabalho realizado. Del Prefácio de Carlos Frederico Dominguez Ávil