206 research outputs found

    PMS7 A 2-YEAR EVALUATION OF INFLIXIMAB'S EFFECTIVENESS IN THE TREATMENT OF RHEUMATOID ARTHRITIS IN ACTUAL PRACTICE

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    Dynamic Key-Value Memory Networks for Knowledge Tracing

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    Knowledge Tracing (KT) is a task of tracing evolving knowledge state of students with respect to one or more concepts as they engage in a sequence of learning activities. One important purpose of KT is to personalize the practice sequence to help students learn knowledge concepts efficiently. However, existing methods such as Bayesian Knowledge Tracing and Deep Knowledge Tracing either model knowledge state for each predefined concept separately or fail to pinpoint exactly which concepts a student is good at or unfamiliar with. To solve these problems, this work introduces a new model called Dynamic Key-Value Memory Networks (DKVMN) that can exploit the relationships between underlying concepts and directly output a student's mastery level of each concept. Unlike standard memory-augmented neural networks that facilitate a single memory matrix or two static memory matrices, our model has one static matrix called key, which stores the knowledge concepts and the other dynamic matrix called value, which stores and updates the mastery levels of corresponding concepts. Experiments show that our model consistently outperforms the state-of-the-art model in a range of KT datasets. Moreover, the DKVMN model can automatically discover underlying concepts of exercises typically performed by human annotations and depict the changing knowledge state of a student.Comment: To appear in 26th International Conference on World Wide Web (WWW), 201

    Entropic Interactions in Suspensions of Semi-Flexible Rods: Short-Range Effects of Flexibility

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    We compute the entropic interactions between two colloidal spheres immersed in a dilute suspension of semi-flexible rods. Our model treats the semi-flexible rod as a bent rod at fixed angle, set by the rod contour and persistence lengths. The entropic forces arising from this additional rotational degree of freedom are captured quantitatively by the model, and account for observations at short range in a recent experiment. Global fits to the interaction potential data suggest the persistence length of fd-virus is about two to three times smaller than the commonly used value of 2.2ÎĽm2.2 \mu {m}.Comment: 4 pages, 5 figures, submitted to PRE rapid communication

    Foreign Direct Investments in Business Services: Transforming the Visegrád Four Region into a Knowledge-based Economy?

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    Foreign direct investments (FDIs) in the service sector are widely attributed an important role in bringing more skill-intensive activities into the Visegrad Four (V4). This region—comprising Poland, the Czech Republic, Hungary and Slovakia—relied heavily on FDIs in manufacturing, which was often found to generate activities with limited skill content. This contribution deconstructs the chaotic concept of “business services” by analysing the actual nature of service sector activities outsourced and offshored to the V4. Using the knowledge-based economy (KBE) as a benchmark, the paper assesses the potential of service sector outsourcing in contributing to regional competitiveness by increasing the innovative capacity. It also discusses the role of state policies towards service sector FDI (SFDI). The analysis combines data obtained from case studies undertaken in service sector outsourcing projects in V4 countries. Moreover, it draws on interviews with senior employees of investment promotion agencies and publicly available data and statistics on activities within the service sector in the region. It argues that the recent inward investments in business services in the V4 mainly utilize existing local human capital resources, and their contribution to the development of the KBE is limited to employment creation and demand for skilled labour

    Effective forces in colloidal mixtures: from depletion attraction to accumulation repulsion

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    Computer simulations and theory are used to systematically investigate how the effective force between two big colloidal spheres in a sea of small spheres depends on the basic (big-small and small-small) interactions. The latter are modeled as hard-core pair potentials with a Yukawa tail which can be both repulsive or attractive. For a repulsive small-small interaction, the effective force follows the trends as predicted by a mapping onto an effective non-additive hard-core mixture: both a depletion attraction and an accumulation repulsion caused by small spheres adsorbing onto the big ones can be obtained depending on the sign of the big-small interaction. For repulsive big-small interactions, the effect of adding a small-small attraction also follows the trends predicted by the mapping. But a more subtle ``repulsion through attraction'' effect arises when both big-small and small-small attractions occur: upon increasing the strength of the small-small interaction, the effective potential becomes more repulsive. We have further tested several theoretical methods against our computer simulations: The superposition approximation works best for an added big-small repulsion, and breaks down for a strong big-small attraction, while density functional theory is very accurate for any big-small interaction when the small particles are pure hard-spheres. The theoretical methods perform most poorly for small-small attractions.Comment: submitted to PRE; New version includes an important quantitative correction to several of the simulations. The main conclusions remain unchanged thoug

    Knowledge Tracing with Sequential Key-Value Memory Networks

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    Can machines trace human knowledge like humans? Knowledge tracing (KT) is a fundamental task in a wide range of applications in education, such as massive open online courses (MOOCs), intelligent tutoring systems, educational games, and learning management systems. It models dynamics in a student's knowledge states in relation to different learning concepts through their interactions with learning activities. Recently, several attempts have been made to use deep learning models for tackling the KT problem. Although these deep learning models have shown promising results, they have limitations: either lack the ability to go deeper to trace how specific concepts in a knowledge state are mastered by a student, or fail to capture long-term dependencies in an exercise sequence. In this paper, we address these limitations by proposing a novel deep learning model for knowledge tracing, namely Sequential Key-Value Memory Networks (SKVMN). This model unifies the strengths of recurrent modelling capacity and memory capacity of the existing deep learning KT models for modelling student learning. We have extensively evaluated our proposed model on five benchmark datasets. The experimental results show that (1) SKVMN outperforms the state-of-the-art KT models on all datasets, (2) SKVMN can better discover the correlation between latent concepts and questions, and (3) SKVMN can trace the knowledge state of students dynamics, and a leverage sequential dependencies in an exercise sequence for improved predication accuracy

    Neural Correlates of Appetite and Hunger-Related Evaluative Judgments

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    How much we desire a meal depends on both the constituent foods and how hungry we are, though not every meal becomes more desirable with increasing hunger. The brain therefore needs to be able to integrate hunger and meal properties to compute the correct incentive value of a meal. The present study investigated the functional role of the amygdala and the orbitofrontal cortex in mediating hunger and dish attractiveness. Furthermore, it explored neural responses to dish descriptions particularly susceptible to value-increase following fasting. We instructed participants to rate how much they wanted food menu items while they were either hungry or sated, and compared the rating differences in these states. Our results point to the representation of food value in the amygdala, and to an integration of attractiveness with hunger level in the orbitofrontal cortex. Dishes particularly desirable during hunger activated the thalamus and the insula. Our results specify the functions of evaluative structures in the context of food attractiveness, and point to a complex neural representation of dish qualities which contribute to state-dependent value
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