Current trend in synthesis, Post-Synthetic modifications and biological applications of Nanometal-Organic frameworks (NMOFs)

Since the early reports of MOFs and their interesting properties, research involving these materials has grown wide in scope and applications. Various synthetic approaches have ensued in view of obtaining materials with optimised properties, the extensive scope of application spanning from energy, gas sorption, catalysis biological applications has meant exponentially evolved over the years. The far‐reaching synthetic and PSM approaches and porosity control possibilities have continued to serve as a motivation for research on these materials. With respect to the biological applications, MOFs have shown promise as good candidates in applications involving drug delivery, BioMOFs, sensing, imaging amongst others. Despite being a while away from successful entry into the market, observed results in sensing, drug delivery, and imaging put these materials on the spot light as candidates poised to usher in a revolution in biology. In this regard, this review article focuses current approaches in synthesis, post functionalization and biological applications of these materials with particular attention on drug delivery, imaging, sensing and BioMOFs

New crown ether-based ionic liquids as a green and versatile organocatalyst for three-component synthesis of 1,5-dihydropyrano2,3-cchromene derivatives

A simple and green method for the synthesis of 1,5-dihydropyrano2,3-cchromene derivatives has been reported by three-component reaction of aromatic aldehydes, malononitrile, and 3-hydroxycoumarin in the presence of a series of novel crown ether-based ionic liquids (CE-based ILs) in H2O/EtOH (1:1), under the reflux conditions. The novel CE-based ILs have been synthesized by 18-crown-6 or dibenzo 18-crown-6 chelated with sodium benzenesulfinate derivatives and used as a green and environmental organocatalyst. This method has some advantages such as the aqueous reaction medium, stable catalysts, cleaner reaction profiles and high yield of products in short reaction time. © 2020 Bentham Science Publishers

Systematic Study of NaF Nanoparticles in Micelles loaded on Polylactic Acid Nanoscaffolds: In Vitro Efficient Delivery

Abstract: The overall aim of this work was developing and optimized NaF nanoparticles in micelles structures loaded on polylactic acid nanoscaffolds as biocompatible and biodegradable polymers for use in dental delivery. In this research, NaF nanoparticles were successfully synthesized in micelles structures and loaded on the biopolymers on as dental resins through direct micelle assisted electrospinning method. NaF nanoparticles as a heterogeneous structure were dispersed in biopolymers nanoscaffolds which makes it suitable in dental delivery. The synthesis parameters for preparation of NaF nanoparticles loaded on polylactic acid nanoscaffolds were evaluated by design of experiments and the process control was systematically studied using analysis of variance. Products were characterized with scanning electron microscopy, transmission electron microscopy, atomic force microscopy, Fourier-transform infrared spectroscopy, thermogravimetric analysis, Brunauer�Emmett�Teller and nitrogen adsorption isotherms. In vitro drug release of NaF nanoparticles loaded on polylactic acid nanoscaffolds was studied with Franz Cells and data release was investigated through UV�vis spectroscopy about λ = 486. The obtained results showed the released value of NaF nanoparticles from the formulation containing 0.5 PLA at λ = 486 nm about 84 after 240 min. Graphic Abstract: Figure not available: see fulltext.. © 2019, Springer Science+Business Media, LLC, part of Springer Nature

The assessment of apoptosis, toxicity effects and anti-leishmanial study of Chitosan/CdO core-shell nanoparticles, eco-friendly synthesis and evaluation

Leishmaniasis is a parasitic disease that can be transmitted to individuals by a species of the Leishmania flagellated protozoan. Due to problems such as toxicity, high cost, long duration of treatment, increased drug resistance, painful injections, and side effects, leishmaniasis is considered as an important epidemic in people with systemic deficits. Therefore, in this study, new core�shell nanostructures were introduced as anti-leishmanial drugs for the first time. The expression of IFN-γ, TNF-α, IL-4, and IL-12 genes were evaluated by real-time PCR. Investigations revealed that CdO/Chitosan core shell nanostructures decreased the proliferation of promastigotes (p < 0.0001). The number of promastigotes were reduced in the presence of different concentrations of the nanostructures. The average value of IC50 for promastigotes was about 0.6 µg/mL. The concentration of the drug that prevented the growth of 50 of macrophages for core shell nanostructures was 1.256 μg/mL. The level of apoptosis in leishmania promastigotes in the presence of nanodots at the concentrations of 1, 0.5, and 0.25 µg/mL was 56, 31, and 23, respectively. Furthermore, according to the results, it can be concluded that the level of gene expression pertaining to Th1 was significantly up-regulated (p < 0.001). This study showed that the core�shell nanodots of chitosan/cadmium oxide inhibit the proliferation of promastigotes and increase the apoptosis of leishmania promastigotes. © 2021 The Author