Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence.

BackgroundCigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence. Smokers also exhibit lower dopamine D2/3 receptor availability in the dorsal striatum than nonsmokers. Negative correlations of striatal dopamine D2/3 receptor availability with smoking exposure and nicotine dependence, therefore, might be expected but have not been tested.MethodsTwenty smokers had positron emission tomography scans with [18F]fallypride to measure dopamine D2/3 receptor availability in ventral and dorsal regions of the striatum and provided self-report measures of recent and lifetime smoking and of nicotine dependence.ResultsAs reported before, lifetime smoking was correlated with nicotine dependence. New findings were that ventral striatal dopamine D2/3 receptor availability was negatively correlated with recent and lifetime smoking and also with nicotine dependence.ConclusionThe results suggest an effect of smoking on ventral striatal D2/3 dopamine receptors that may contribute to nicotine dependence

Relationship of Alexithymia Ratings to Dopamine D2-type Receptors in Anterior Cingulate and Insula of Healthy Control Subjects but Not Methamphetamine-Dependent Individuals.

BackgroundIndividuals with substance-use disorders exhibit emotional problems, including deficits in emotion recognition and processing, and this class of disorders also has been linked to deficits in dopaminergic markers in the brain. Because associations between these phenomena have not been explored, we compared a group of recently abstinent methamphetamine-dependent individuals (n=23) with a healthy-control group (n=17) on dopamine D2-type receptor availability, measured using positron emission tomography with [(18)F]fallypride.MethodsThe anterior cingulate and anterior insular cortices were selected as the brain regions of interest, because they receive dopaminergic innervation and are thought to be involved in emotion awareness and processing. The Toronto Alexithymia Scale, which includes items that assess difficulty in identifying and describing feelings as well as externally oriented thinking, was administered, and the scores were tested for association with D2-type receptor availability.ResultsRelative to controls, methamphetamine-dependent individuals showed higher alexithymia scores, reporting difficulty in identifying feelings. The groups did not differ in D2-type receptor availability in the anterior cingulate or anterior insular cortices, but a significant interaction between group and D2-type receptor availability in both regions, on self-report score, reflected significant positive correlations in the control group (higher receptor availability linked to higher alexithymia) but nonsignificant, negative correlations (lower receptor availability linked to higher alexithymia) in methamphetamine-dependent subjects.ConclusionsThe results suggest that neurotransmission through D2-type receptors in the anterior cingulate and anterior insular cortices influences capacity of emotion processing in healthy people but that this association is absent in individuals with methamphetamine dependence

Structure Transformation between Perovskite-type and B-type Rare Earth Structures

AbstractLaLnO3 (Ln = Dy, Ho, Y, Er, and Yb) and La(Ln, Ln’)O3 (Ln, Ln’ = Dy, Ho, Er, and Yb) systems were synthesized by solid state reaction method and characterized by X-ray diffraction. When Ln = Er or Yb which has smaller ionic radius than that of Y3+ (0.900Å), the LaLnO3 showed an orthorhombic perovskite structure, while when Ln = Dy or Ho which has larger ionic radius than that of Y3+, it showed a monoclinic B-type rare earth structure. Next, the solid solution system of LaHoxYb1-xO3 was investigated in order to clarify the crystallochemical factor affecting the structural transformation. The XRD experiments revealed that the samples with x = 0.90 (rav.=0.8977Å) showed the orthorhombic perovskite structure, changed to the mixed phases of monoclinic B-type rare earth, and orthorhombic perovskite structures with increasing x, and then the samples with x ≥ 0.95 (rav.=0.8994Å) showed the monoclinic B-type rare earth structures, where rav. represents the average ionic radii of Ln and Ln’

Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients

ArticleHEPATOLOGY RESEARCH. 32(3): 173-184 (2005)journal articl