A Frame Work for Ensuring Security and Privacy of PHR’S

Creating procedures to safely store information crosswise over cloud is a quite interesting research topic of late. Distributed computing concentrates on amplifying the viability of the common assets and is advantageousfor putting away / recovery of enormous measure of information. Personal Health Records (PHRs) areconsidered to remain the long lasting property of patients and have to be displayable helpfully and safely to choose guardians. My PHR Machine is a patient driven framework that takes a new structural approach for PHR interoperability. Patients can upload their medical information and share through remote Virtual machine. We have made a study on methods to secure PHRs and discover open model of My PHR Machines for the utilization instance of a certifiable patient situation

Analysis of fixed dose combinations of expectorants, antitussives, decongestants, antihistamines and mucolytics available in the Indian market for rationality and cost variation

Background: Aim of the current study was to analyze the FDCs of expectorants, antitussives, decongestants, antihistamines and mucolytics available in the Indian market for their rationality, cost, and dosage forms. Methods: FDCs involving expectorants, antitussives, decongestants, antihistamines and mucolytics listed on Drug Today and Jan Aushadhi online portal were analysed for rationality according to the list of banned FDCs by CDSCO published on 01 Jan 2018. The FDCs with EADAM available in Jan Aushadhi online portal are compared with cost of different brands with same composition, strength and dosage form available in the Indian market as per the latest drug today. The cost ratio and percentage cost variation were calculated for each FDC. Results: Out of total 340 oral formulations, 268 were liquid and 72 were solid formulations. 228 were Syrups, 67 were Tablets, 23 were Drops, 17 were Suspension and 5 were Capsules. Out of 47 banned FDCs, branded FDC with Ammonium chloride 50mg, Bromhexine 4mg, Dextromethorphan 5mg and Menthol in syrup form was still available for over-the-counter purchase and for online purchase with prescription. Percentage cost variation between branded and generic FDCs ranged from 99% for Terbutaline 2.5 mg and Bromhexine 8 mg to 1081% for Terbutaline 1.25 mg, Bromhexine 4mg, Guaiphenesin 50 mg and Menthol 2.5 mg. Conclusions: One among 47 Banned FDCs was available at both online apps and drug stores. These irrational FDCs can be risk to human lives. The drug authorities need to tune the price of these FDCs as there is a huge percentage cost variation between generic and branded products

Self-modulation instability of a long proton bunch in plasmas

An analytical model for the self-modulation instability of a long relativistic proton bunch propagating in uniform plasmas is developed. The self-modulated proton bunch resonantly excites a large amplitude plasma wave (wake field), which can be used for acceleration of plasma electrons. Analytical expressions for the linear growth rate and the number of exponentiations are given. We use the full three-dimensional particle-in-cell (PIC) simulations to study the beam self-modulation and the transition to the nonlinear stage. It is shown that the self-modulation of the proton bunch competes with the hosing instability which tends to destroy the plasma wave. A method is proposed and studied through PIC simulations to circumvent this problem which relies on the seeding of the self-modulation instability in the bunch

Formulation and Evaluation of Oral Disintegrating Tablets of an Anti Migraine Drug

In recent years, the importance of patient compliance,not only in drug efficacy but also in overall economicsof healthcare, has been increasingly recognized. Efforts toimprove patient compliance have included attempts toimprove the palatability of orally administered pharmaceuticalagents especially for children and elderly. Inparticular, a bitter taste is known to decrease patientcompliance, and thus reduce effective pharmacotherapy.Various techniques are used to mask the bitter taste of drug. In the present work, model drug is a moderately bitter drug,an attempt has been made to mask the taste of modeldrug by using sweetners like aspartame and mannitol in the formulation. The literature survey revealed that no work has been reported on ODT of the modeldrug OBJECTIVE:The main objective is to formulate ODT’S by using different superdisintegrants and sweetners in different ratio’s and evaluating its characteristics in order to improve the release rate,disintegration time, tastemasking and also providing better patient compliance.In vitro dissolution studies: 12 Dissolution study was conducted for formulations with different disintegrants using USP type-II apparatus (ELECTROLAB). The dissolution test was performed in buffers of different pH(0.1N HCl,6.8Phosphate buffer,4.5Acetate buffer, Water)50rpm and at a temperature of 370C±0.50C for 30 minutes. Ten milliliters of aliquots were periodically withdrawn at time intervals of 5, 10, 15, 20,and 30minutes. Then the sample volume was replaced with an equal volume of fresh dissolution medium. The samples were diluted and analyzed spectrophotometrically at 227nm

Soft Computing and Artificial Intelligence Techniques for Intrusion Detection System

The rapid development of computer networks and mostly of the Internet has created many stability and security problems such as intrusions on computer and network systems. Further the dependency of companies and government agencies is increasing on their computer networks and the significance of protecting these systems from attacks is serious because a single intrusion can cause a heavy loss or the consistency of network becomes insecure. During recent years number of intrusions has dramatically increased. Therefore it is very important to prevent such intrusions. The hindrance of such intrusions is entirely dependent on their detection that is a key part of any security tool such as Intrusion Detection System (IDS), Intrusion Prevention System (IPS), Adaptive Security Alliance (ASA), checkpoints and firewalls. Hence accurate detection of network attack is imperative. A variety of intrusion detection approaches are available but the main problem is their performance, which can be enhanced by increasing the detection rates and reducing false positives. Keywords: IDS, Soft Computing, ANN, Genetic Algorith

Perovskite solar cells: progress and advancements

Organic–inorganic hybrid perovskite solar cells (PSCs) have emerged as a new class of optoelectronic semiconductors that revolutionized the photovoltaic research in the recent years. The perovskite solar cells present numerous advantages include unique electronic structure, bandgap tunability, superior charge transport properties, facile processing, and low cost. Perovskite solar cells have demonstrated unprecedented progress in efficiency and its architecture evolved over the period of the last 5–6 years, achieving a high power conversion efficiency of about 22% in 2016, serving as a promising candidate with the potential to replace the existing commercial PV technologies. This review discusses the progress of perovskite solar cells focusing on aspects such as superior electronic properties and unique features of halide perovskite materials compared to that of conventional light absorbing semiconductors. The review also presents a brief overview of device architectures, fabrication methods, and interface engineering of perovskite solar cells. The last part of the review elaborates on the major challenges such as hysteresis and stability issues in perovskite solar cells that serve as a bottleneck for successful commercialization of this promising PV technology

UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS QUANTITATIVE ESTIMATION OF MEBEVERINE HYDROCHLORIDE AND CHLORDIAZEPOXIDE IN CAPSULES

Objective: To develop a simple and cheap UV spectrophotometric method for the simultaneous quantitative estimation of Mebeverine hydrochloride (135mg) and Chlordiazepoxide (5mg) in MEVA C Capsules and validate as per ICH guidelines. Methods: The optimized method uses a diluent 100% Triethylammonium phosphate buffer (pH 3.0) for the estimation of assay of Mebeverine hydrochloride and Chlordiazepoxide in Capsules which are analyzed at a detection wavelength of 260nm. Results: The developed method exhibited linearity in the range of 10-40μg/ml for Mebeverine hydrochloride and 2.5-10μg/ml for Chlordiazepoxide. The precision for Mebeverine hydrochloride and Chlordiazepoxide is exemplified by relative standard deviation of 0.499% and 1.75 respectively. Percentage Mean recovery for Mebeverine hydrochloride and Chlordiazepoxide were found to be in the range of 98â€102, during accuracy studies. The limit of detection (LOD) for Mebeverine hydrochloride and Chlordiazepoxide were found to be 321ng/ml and 3.7ng/ml respectively, while limit of quantitiation (LOQ) for Mebeverine hydrochloride and Chlordiazepoxide were found to be 973ng/ml and 11.2ng/ml respectively. Conclusion: A simple and a cheap UV spectrophotometric method was developed and validated for the simultaneous quantitative estimation of Mebeverine hydrochloride and Chlordiazepoxide in capsules as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries

FORUM CRAWLER UNDER SUPERVISION METHODOLOGY FOR AUTHENTICATION PATH IN WEB FORUMS

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