Determination and Correlation of Anticardiolipin Antibody with High Sensitivity C- reactive Proteins and its Role in Predicting Short Term Outcome in Patients with Acute Coronary Syndrome

Anticardiolipin antibody (aCL) is considered to be an independent risk factor while high sensitivity C reactive protein (hsCRP) is an established marker for coronary artery disease. This study was conducted to determine levels of aCL antibodies and hsCRP, their correlation and role in predicting recurrence of events in patients presenting with Acute Coronary Syndrome (ACS). Sixty patients admitted with Acute Coronary Syndrome were followed up for 7 days or until discharge. Patients were classified into two groups as those having experienced an ischemic event needing intervention within 7 days (Group I) and other having an event free recovery (Group II). aCL antibody and hsCRP levels were estimated and compared in these two groups. Twenty age and sex matched disease free persons served as controls. The levels of aCL were significantly higher in patients with ACS as compared to the controls (p=0.020). However the levels of aCL in Group I (13.39±9.46 GPL-U/ml) and Group II (13.51±9.93 GPL-U/ml) were not significantly different (p =0.838). The mean hsCRP levels were higher in cases with an event (23.30±10.68 mg/dl) than in cases without an event (20.60±11.45mg/dl) though it was not significant statistically (p=0.389). aCL and CRP were not found to be significantly correlated in causing the recurrence of events(p=0.178). Therefore anticardiolipin antibody is an independent risk factor which could be implicated in the pathogenesis of ACS. However it is not significantly associated with recurrence of short-term events in patients with ACS. Also, aCL antibody does not have significant correlation with hSCRP in causing recurrence of events in the patients of acute coronary syndrome

Coronal Emission Measures and Abundances for Moderately Active K Dwarfs Observed by Chandra

We have used Chandra to resolve the nearby 70 Oph (K0 V+K5 V) and 36 Oph (K1 V+K1 V) binary systems for the first time in X-rays. The LETG/HRC-S spectra of all four of these stars are presented and compared with an archival LETG spectrum of another moderately active K dwarf, Epsilon Eri. Coronal densities are estimated from O VII line ratios and emission measure distributions are computed for all five of these stars. We see no substantial differences in coronal density or temperature among these stars, which is not surprising considering that they are all early K dwarfs with similar activity levels. However, we do see significant differences in coronal abundance patterns. Coronal abundance anomalies are generally associated with the first ionization potential (FIP) of the elements. On the Sun, low-FIP elements are enhanced in the corona relative to high-FIP elements, the so-called "FIP effect." Different levels of FIP effect are seen for our stellar sample, ranging from 70 Oph A, which shows a prominent solar-like FIP effect, to 70 Oph B, which has no FIP bias at all or possibly even a weak inverse FIP effect. The strong abundance difference exhibited by the two 70 Oph stars is unexpected considering how similar these stars are in all other respects (spectral type, age, rotation period, X-ray flux). It will be difficult for any theoretical explanation for the FIP effect to explain how two stars so similar in all other respects can have coronae with different degrees of FIP bias. Finally, for the stars in our sample exhibiting a FIP effect, a curious difference from the solar version of the phenomenon is that the data seem to be more consistent with the high-FIP elements being depleted in the corona rather than a with a low-FIP enhancementComment: 35 pages, 8 figures, AASTEX v5.0 plus EPSF extensions in mkfig.sty; accepted by Ap

Optimized coupling of cold atoms into a fiber using a blue-detuned hollow-beam funnel

We theoretically investigate the process of coupling cold atoms into the core of a hollow-core photonic-crystal optical fiber using a blue-detuned Laguerre-Gaussian beam. In contrast to the use of a red-detuned Gaussian beam to couple the atoms, the blue-detuned hollow-beam can confine cold atoms to the darkest regions of the beam thereby minimizing shifts in the internal states and making the guide highly robust to heating effects. This single optical beam is used as both a funnel and guide to maximize the number of atoms into the fiber. In the proposed experiment, Rb atoms are loaded into a magneto-optical trap (MOT) above a vertically-oriented optical fiber. We observe a gravito-optical trapping effect for atoms with high orbital momentum around the trap axis, which prevents atoms from coupling to the fiber: these atoms lack the kinetic energy to escape the potential and are thus trapped in the laser funnel indefinitely. We find that by reducing the dipolar force to the point at which the trapping effect just vanishes, it is possible to optimize the coupling of atoms into the fiber. Our simulations predict that by using a low-power (2.5 mW) and far-detuned (300 GHz) Laguerre-Gaussian beam with a 20-{\mu}m radius core hollow-fiber it is possible to couple 11% of the atoms from a MOT 9 mm away from the fiber. When MOT is positioned further away, coupling efficiencies over 50% can be achieved with larger core fibers.Comment: 11 pages, 12 figures, 1 tabl

In Vitro Propagation and Conservation of Inula Racemosa Hook. F. an Endangered Medicinal Plant of Temperate Origin

Inula racemosa is an endangered medicinal plant. It is commonly known as Pushkarmool, Pushkar and Manu. The great sage Charaka has characterized it as Hikka magrahana (stops hiccups) and Savasahara (helpful in asthma). Also, he has cited it as the best medicament for pleurisy along with cough and asthma (http://enwikipedia.org/wiki/charaka-samhita). Due to the fragile nature of its habitat and exploitation due to its commercial medicinal properties, the species are facing the onslaught of indiscriminate over-exploitation. So far, this plant has not got the required attention from researchers, hence, except for a few efforts, not much work has been done for its cultivation and conservation. Plant tissue culture offers an attractive and quick method for its multiplication and further conservation. In the present investigation, effective procedures for micropropagation and in vitro conservation by vitrification were developed. In vitro propagation using aseptically grown seedlings and in vitro conservation via vitrification were standardized. The in vitro conserved material could be retrieved and multiplied normally on MS (Murashige and Skoog, 1962) medium fortified with 1.00 mg l-1BA (benzyl adenine) which has been recorded as the best performing medium for in vitro shoot multiplication. The conserved shoots showed normal in vitro propagation and after retrieval from vitrification, platelets were hardened and successfully established in the experimental fields under Nauni (Solan, HP) conditions at an elevation of around 1275 meters above mean sea level

Differential diagnosis of tuberculous meningitis from partially-treated pyogenic meningitis by cell ELISA

BACKGROUND: Tuberculous meningitis (TBM) is a major global health problem, and it is sometimes difficult to perform a differential diagnosis of this disease from other diseases, particularly partially-treated pyogenic meningitis (PTPM). In an earlier study, we demonstrated the presence of a 30-kD protein antigen in cerebrospinal fluid (CSF) of TBM patients. We have also shown that lymphocytes from CSF of TBM patients respond differently to this antigen than do those from PTPM patients. The purpose of this study was to develop an assay that can discriminate between TBM and PTPM. METHODS: We developed a cell enzyme-linked immunosorbant assay (Cell ELISA) to quantitatively measure production of antibodies against the 30-kD protein in B cells from CSF of TBM and PTPM patients. RESULTS: The cell ELISA yielded 92% (11/12) sensitivity and 92% (11/12) specificity for the differential diagnosis of TBM from PTPM. CONCLUSION: When induced with the 30-kD protein antigen, B cells derived from CSF of TBM patients respond to IgG production within 24 h while those derived from PTPM patients do not respond

Detailed diagnostics of an X-ray flare in the single giant HR 9024

We analyze a 96 ks Chandra/HETGS observation of the single G-type giant HR 9024. The high flux allows us to examine spectral line and continuum diagnostics at high temporal resolution, to derive plasma parameters. A time-dependent 1D hydrodynamic model of a loop with half-length $L = 5 \times 10^{11}$ cm ($\sim R_{\star}/2$), cross-section radius $r = 4.3 \times 10^{10}$ cm, with a heat pulse of 15 ks and $2 \times 10^{11}$~erg cm$^{-2}$ s$^{-1}$ deposited at the loop footpoints, satisfactorily reproduces the observed evolution of temperature and emission measure, derived from the analysis of the strong continuum emission. For the first time we can compare predictions from the hydrodynamic model with single spectral features, other than with global spectral properties. We find that the model closely matches the observed line emission, especially for the hot ($\sim 10^8$ K) plasma emission of the FeXXV complex at $\sim 1.85$\AA. The model loop has $L/R_{\star} \sim 1/2$ and aspect ratio $r/L \sim 0.1$ as typically derived for flares observed in active stellar coronae, suggesting that the underlying physics is the same for these very dynamic and extreme phenomena in stellar coronae independently on stellar parameters and evolutionary stage.Comment: 26 pages. Accepted for publication on the Astrophysical Journa

Is there too much benchmarking in asset management?

We propose a tractable model of asset management in which benchmarking arises endogenously, and analyze its welfare consequences. Fund managers’ portfolios are not contractible and they incur private costs in running them. Incentive contracts for fund managers create a pecuniary externality through their effect on asset prices. Benchmarking inflates asset prices and creates crowded trades. The crowding reduces the effectiveness of benchmarking in incentive contracts for others, which fund investors fail to account for. A social planner, recognizing the crowding, opts for contracts with less benchmarking and less incentive provision. The planner also delivers lower asset management costs