54 research outputs found
Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis - the effect of sex, Kellgren-Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation
Hippocampal Cell Distributions in Temporal Lobe Epilepsy: A Comparison Between Patients With and Without an Early Risk Factor
Quantitative Comparison of Cell Loss and Thiopental-Induced EEG Changes in Human Epileptic Hippocampus
The pilocarpine model of epilepsy in mice
Purpose: To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice.Methods: After status epilepticus, the surviving animals were continuously monitored for 24 h/day for less than or equal to 120 days. the brains were processed by using neo-Timm and Nissl stains.Results: the first spontaneous seizures occurred between 4 and 42 days after status epilepticus. the mean ''seizure-silent period'' lasted for 14.4 +/- 11.9 days. During the chronic phase, recurrent spontaneous seizures were observed 1-5 times per animal per week and were associated with sprouting in the supragranular layer of the dentate gyrus.Conclusions: Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice.UNIFESP, EPM, RUA BOTUCATU 862, BR-04023900 São Paulo, BRAZILUNIFESP, EPM, RUA BOTUCATU 862, BR-04023900 São Paulo, BRAZILWeb of Scienc
AUTOMATED DIFFERENTIAL CELL COUNTING ON A SECTOR OF THE NORMAL HUMAN HIPPOCAMPUS: THE INFLUENCE OF AGE
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