319 research outputs found
Reduced Phagocytic Capacity of Blood Monocyte/Macrophages in Tuberculosis Patients Is Further Reduced by Smoking.
Tuberculosis (TB) and tobacco use are two major alarming global health issues posing immense threats to human populations. Mycobacterium tuberculosis (MTB) by activation of macrophages could induce the sequences of cells activation and releases of inflammatory cytokines such as CXCL-8, Il-12 and TNF-α which in turn induces the immune system network. However no information is available on other activity of cells by MTB and smoking. In the current study we aimed to investigate the serum levels TNF-a, CXCL-8 and phagocytosis capacity in tuberculosis patients with and without smoking. 103 subjects entered the study including 61 new diagnosed pulmonary TB patients (23 smokers and 38 nonsmokers) and 42 control healthy subjects. The phagocytosis of fluorescein isothiocyanate dextran (FITC-dextran) in blood monocytes/macrophages through flowcytometry was assessed. Serum levels of TNF-a and CXCL-8 were analyzed by ELISA methods. A lower percentage of cells from TB patients who smoked [50.29% (43.4-57.2), p<0.01] took up FITC-dextran after 2h compared to non-smoking TB subjects [71.62% (69.2-74.1)] and healthy cases [97.45% (95.9-99.1). Phagocytic capacity was inversely correlated with cigarette smoking as measured by pack years (r=-0.73, p<0.001). The serum levels of TNF-a and CXCL-8 were significantly higher in the TB patients who smoked compared to the TB non-smoker group (p<0.001, p<0.01 respectively). Blood monocytes/macrophages from TB patients have reduced phagocytic capacity which is further reduced in TB patients who smoke. Smoking enhanced serum levels of TNF-a and CXCL-8 suggesting a greater imbalance between the proinflammatory and anti-inflammatory factors in these patients
The Baryon Content of Extremely Low Mass Dwarf Galaxies
We investigate the gas content and baryonic Tully-Fisher relationship for
extremely low luminosity dwarf galaxies in the absolute magnitude range -13.5 >
Mr > -16. The sample is selected from the Sloan Digital Sky Survey and consists
of 101 galaxies for which we have obtained follow-up HI observations using the
Arecibo Observatory and Green Bank Telescope. This represents the largest
homogeneous sample of dwarfs at low luminosities with well-measured HI and
optical properties. The sample spans a range of environments, from dense groups
to truly isolated galaxies. The average neutral gas fraction is f_gas=0.6,
significantly exceeding that of typical gas-rich galaxies at higher
luminosities. Dwarf galaxies are therefore less efficient at turning gas into
stars over their lifetimes. The strong environmental dependence of the gas
fraction distribution demonstrates that while internal processes can reduce the
gas fractions to roughly f_gas=0.4, external processes are required to fully
remove gas from a dwarf galaxy. The average rotational velocity of our sample
is vrot=50 km/s. Including more massive galaxies from the literature, we fit a
baryonic Tully-Fisher slope of M_baryon \propto vrot^(3.70+/- 0.15). This slope
compares well with CDM models that assume an equal baryon to dark matter ratio
at all masses. While gas stripping or other processes may modify the baryon to
dark matter ratio for dwarfs in the densest environments, the majority of dwarf
galaxies in our sample have not preferentially lost significant baryonic mass
relative to more massive galaxies.Comment: 33 pages, 8 figures. Accepted to ApJ. Data available at
http://www.ociw.edu/~mgeha/researc
Birmingham Mid-Head Resection Periprosthetic Fracture.
Total hip arthroplasty in the young leads to difficult choices in implant selection. Until recently bone conserving options were not available for younger patients with deficient femoral head bone stock. The novel Birmingham Mid-Head Resection (BMHR) device offers the option of bone conserving arthroplasty in spite of deficient femoral head bone stock. Femoral neck fracture is a known complication of standard resurfacing arthroplasty and is the most common reason for revision. It is unknown whether this remains to be the case for the BMHR neck preserving implants. We report a case of a 57-year-old male, who sustained a periprosthetic fracture following surgery with a BMHR arthroplasty. This paper illustrates the first reported case of a BMHR periprosthetic fracture. The fracture pattern is spiral in nature and reaches to the subtrochanteric area. This fracture pattern is different from published cadaveric studies, and clinicians using this implant should be aware of this as revision is likely to require a distally fitting, rather than a metaphyseal fitting stem. We have illustrated the surgical technique to manage this rare complication
Comparison of gait biomechanics in patients with and without knee osteoarthritis during different phases of gait
Background: This study aimed to characterise knee adduction angles (KAA) and knee adduction moments (KAM) and compare this with foot centre of pressure (COP) in volunteers with and without knee
osteoarthritis (OA).
Methods: A total of 108 participants were recruited; 84 had no known pathology, 18 had medial knee OA,
and six had lateral knee OA. Linear regression was used to determine correlations between the normalised COP, KAM, and KAA during each phase of gait for all participants.
Results: The first phase of gait demonstrated significant differences between groups for all measures:
KAA in all phases, COP in phases one and two, and KAM in phase one only.
Conclusion: The largest mechanical changes are seen in the first phase of gait in osteoarthritic patients.
Although COP is an easy to measure tool, it is not as sensitive as KAA and did not demonstrate a significant difference between healthy and medial OA patient
What triggers galaxy transformations? The environments of post-starburst galaxies
(abridged) There are good observational reasons to believe that the
progenitors of red galaxies have undergone starbursts, followed by a
post-starburst phase. We investigate the environments of post-starburst
galaxies by measuring \textsl{(1)} number densities in
radius comoving spheres, \textsl{(2)} transverse distances to nearest
Virgo-like galaxy clusters, and \textsl{(3)} transverse distances to nearest
luminous-galaxy neighbors. We compare the post-starburst galaxies to currently
star-forming galaxies identified solely by A-star excess or \Halpha emission.
We find that post-starburst galaxies are in the same kinds of environments as
star-forming galaxies; this is our ``null hypothesis''. More importantly, we
find that at each value of the A-star excess, the star-forming and
post-starburst galaxies lie in very similar distributions of environment. The
only deviations from our null hypothesis are barely significant: a slight
deficit of post-starburst galaxies (relative to the star-forming population) in
very low-density regions, a small excess inside the virial radii of clusters,
and a slight excess with nearby neighbors. None of these effects is strong
enough to make the post-starburst galaxies a high-density phenomenon, or to
argue that the starburst events are primarily triggered by external tidal
impulses (e.g., from close passages of massive galaxies). The small excess
inside cluster virial radii suggests that some post-starbursts are triggered by
interactions with the intracluster medium, but this represents a very small
fraction of all post-starburst galaxies.Comment: ApJ in pres
Cross-correlation Weak Lensing of SDSS Galaxy Clusters III: Mass-to-light Ratios
We present measurements of the excess mass-to-light ratio measured
aroundMaxBCG galaxy clusters observed in the SDSS. This red sequence cluster
sample includes objects from small groups with masses ranging from ~5x10^{12}
to ~10^{15} M_{sun}/h. Using cross-correlation weak lensing, we measure the
excess mass density profile above the universal mean \Delta \rho(r) = \rho(r) -
\bar{\rho} for clusters in bins of richness and optical luminosity. We also
measure the excess luminosity density \Delta l(r) = l(r) - \bar{l} measured in
the z=0.25 i-band. For both mass and light, we de-project the profiles to
produce 3D mass and light profiles over scales from 25 kpc/ to 22 Mpc/h. From
these profiles we calculate the cumulative excess mass M(r) and excess light
L(r) as a function of separation from the BCG. On small scales, where \rho(r)
>> \bar{\rho}, the integrated mass-to-light profile may be interpreted as the
cluster mass-to-light ratio. We find the M/L_{200}, the mass-to-light ratio
within r_{200}, scales with cluster mass as a power law with index 0.33+/-0.02.
On large scales, where \rho(r) ~ \bar{\rho}, the M/L approaches an asymptotic
value independent of cluster richness. For small groups, the mean M/L_{200} is
much smaller than the asymptotic value, while for large clusters it is
consistent with the asymptotic value. This asymptotic value should be
proportional to the mean mass-to-light ratio of the universe . We find
/b^2_{ml} = 362+/-54 h (statistical). There is additional uncertainty in
the overall calibration at the ~10% level. The parameter b_{ml} is primarily a
function of the bias of the L <~ L_* galaxies used as light tracers, and should
be of order unity. Multiplying by the luminosity density in the same bandpass
we find \Omega_m/b^2_{ml} = 0.02+/-0.03, independent of the Hubble parameter.Comment: Third paper in a series; v2.0 incorporates ApJ referee's suggestion
Estimating treatment importance in multidrug-resistant tuberculosis using Targeted Learning : an observational individual patient data network meta-analysis
Persons with multidrugâresistant tuberculosis (MDRâTB) have a disease resulting from a strain of tuberculosis (TB) that does not respond to at least isoniazid and rifampicin, the two most effective antiâTB drugs. MDRâTB is always treated with multiple antimicrobial agents. Our data consist of individual patient data from 31 international observational studies with varying prescription practices, access to medications, and distributions of antibiotic resistance. In this study, we develop identifiability criteria for the estimation of a global treatment importance metric in the context where not all medications are observed in all studies. With stronger causal assumptions, this treatment importance metric can be interpreted as the effect of adding a medication to the existing treatments. We then use this metric to rank 15 observed antimicrobial agents in terms of their estimated addâon value. Using the concept of transportability, we propose an implementation of targeted maximum likelihood estimation, a doubly robust and locally efficient plugâin estimator, to estimate the treatment importance metric. A clustered sandwich estimator is adopted to compute variance estimates and produce confidence intervals. Simulation studies are conducted to assess the performance of our estimator, verify the double robustness property, and assess the appropriateness of the variance estimation approach
The Extreme Small Scales: Do Satellite Galaxies Trace Dark Matter?
We investigate the radial distribution of galaxies within their host dark
matter halos by modeling their small-scale clustering, as measured in the Sloan
Digital Sky Survey. Specifically, we model the Jiang et al. (2011) measurements
of the galaxy two-point correlation function down to very small projected
separations (10 < r < 400 kpc/h), in a wide range of luminosity threshold
samples (absolute r-band magnitudes of -18 up to -23). We use a halo occupation
distribution (HOD) framework with free parameters that specify both the number
and spatial distribution of galaxies within their host dark matter halos. We
assume that the first galaxy in each halo lives at the halo center and that
additional satellite galaxies follow a radial density profile similar to the
dark matter Navarro-Frenk-White (NFW) profile, except that the concentration
and inner slope are allowed to vary. We find that in low luminosity samples,
satellite galaxies have radial profiles that are consistent with NFW. M_r < -20
and brighter satellite galaxies have radial profiles with significantly steeper
inner slopes than NFW (we find inner logarithmic slopes ranging from -1.6 to
-2.1, as opposed to -1 for NFW). We define a useful metric of concentration,
M_(1/10), which is the fraction of satellite galaxies (or mass) that are
enclosed within one tenth of the virial radius of a halo. We find that M_(1/10)
for low luminosity satellite galaxies agrees with NFW, whereas for luminous
galaxies it is 2.5-4 times higher, demonstrating that these galaxies are
substantially more centrally concentrated within their dark matter halos than
the dark matter itself. Our results therefore suggest that the processes that
govern the spatial distribution of galaxies, once they have merged into larger
halos, must be luminosity dependent, such that luminous galaxies become poor
tracers of the underlying dark matter.Comment: 12 pages, 6 figures, Accepted to Ap
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