Cognitive impairment in REM-sleep behaviour disorder and individuals at risk of Parkinson's disease

Background: Mild cognitive impairment (MCI) is commonly present at the time of Parkinson's Disease (PD) diagnosis, but its prevalence amongst individuals at increased risk of PD is unclear. Methods: Cognition was assessed using the Montreal Cognitive Assessment (MoCA) in 208 participants in the PREDICT-PD study, and 25 participants with REM-sleep behaviour disorder (RBD). Prevalence of MCI level I was determined in all participants, and level II MCI in the RBD sub-group. Results: Total MoCA scores were worse in the higher risk than the lower risk group defined as those below the 15th percentile of risk (p = 0.009), and in the RBD group compared to all healthy participants (p < 0.001). The prevalence of MCI level I was 12.8% in the lower-risk, 21.9% in the higher-risk (within the highest 15th percentile) and 64% in RBD participants; 66% of RBD participants had MCI level II with multi-domain MCI, but particularly attention and memory deficits. Conclusions: Cognitive impairment is increased in different groups at higher risk of PD, particularly in the subgroup formally diagnosed with RBD

A review of turbulent skin-friction drag reduction by near-wall transverse forcing

The quest for reductions in fuel consumption and CO2 emissions in transport has been a powerful driving force for scientific research into methods that might underpin drag-reducing technologies for a variety of vehicular transport on roads, by rail, in the air, and on or in the water. In civil aviation, skin-friction drag accounts for around 50% of the total drag in cruise conditions, thus being a preferential target for research. With laminar conditions excluded, skin friction is intimately linked to the turbulence physics in the fluid layer closest to the skin. Hence, research into drag reduction has focused on methods to depress the turbulence activity near the surface. The most effective method of doing so is to exercise active control on the near-wall layer by subjecting the drag-producing ow in this layer to an unsteady and/or spatially varying cross-ow component, either by the action of transverse wall oscillations, by embedding rotating discs into the surface or by plasma-producing electrodes that accelerate the near-wall fluid in the transverse direction. In ideal conditions, drag-reduction margins of order of 50% can thereby be achieved. The present article provides a near-exhaustive review of research into the response of turbulent near-wall layers to the imposition of unsteady and wavy transverse motion. The review encompasses experiments, simulation, analysis and modelling, mainly in channel flows and boundary layers. It covers issues such as the drag-reduction margin in a variety of actuation scenarios and for a wide range of actuation parameters, the underlying physical phenomena that contribute to the interpretation of the origin of the drag reduction, the dependence of the drag reduction on the Reynolds number, passive control methods that are inspired by active control, and a forward look towards possible future research and practical realizations. The authors hope that this review, by far the most extensive of its kind for this subject, will be judged as a useful foundation for future research targeting friction-drag reduction

The Motor Dysfunction Seen in Isolated REM Sleep Behavior Disorder.

BACKGROUND: Isolated Rapid Eye Movement (REM) sleep Behavior Disorder (iRBD) requires quantitative tools to detect incipient Parkinson's disease (PD). METHODS: A motor battery was designed and compared with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS-III) in people with iRBD and controls. This included two keyboard-based tests (BRadykinesia Akinesia INcoordination tap test and Distal Finger Tapping) and two dual tasking tests (walking and finger tapping). RESULTS: We included 33 iRBD patients and 29 controls. The iRBD group performed both keyboard-based tapping tests more slowly (P < 0.001, P = 0.020) and less rhythmically (P < 0.001, P = 0.006) than controls. Unlike controls, the iRBD group increased their walking duration (P < 0.001) and had a smaller amplitude (P = 0.001) and slower (P = 0.007) finger tapping with dual task. The combination of the most salient motor markers showed 90.3% sensitivity for 89.3% specificity (area under the ROC curve [AUC], 0.94), which was higher than the MDS-UPDRS-III (minus action tremor) (69.7% sensitivity, 72.4% specificity; AUC, 0.81) for detecting motor dysfunction. CONCLUSION: Speed, rhythm, and dual task motor deterioration might be accurate indicators of incipient PD in iRBD. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society