Non-Gaussian disorder average in the Sachdev-Ye-Kitaev model

International audienceWe study the effect of the non-Gaussian average over the random couplings in a complex version of the celebrated Sachdev-Ye-Kitaev (SYK) model. Using a Polchinski-like equation and random tensor Gaussian universality, we show that the effect of this non-Gaussian averaging leads to a modification of the variance of the Gaussian distribution of couplings at leading order in N. We then derive the form of the effective action to all orders. An explicit computation of the modification of the variance in the case of a quartic perturbation is performed for both the complex SYK model mentioned above and the SYK generalization proposed in D. Gross and V. Rosenhaus [J. High Energy Phys. 02 (2017) 093]JHEPFG1029-847910.1007/JHEP02(2017)093

Enhancement of hyperthermic damage on M14 melanoma cells by liposome pretreatment

Exponentially growing human melanoma cells (M14 cell line) were pretreated with various amounts of dipalmitoylphosphatidylcholine-containing multilamellar liposomes and then exposed to heat treatment (42.5 degrees C). Cell damage produced by the treatments, given separately or in combination, was evaluated in terms of cell survival. Our results demonstrate that the cell survival at 37 degrees C was not affected by liposome concentrations up to 1000 nmol of phospholipid/2.5 x 10(6) cells, while liposome treatment of cells before heat exposure determined a marked damaging effect even at 100 nmol of phospholipid/2.5 x 10(6) cells. The mechanisms of liposome-cell interaction have been investigated by electron microscopy or by electron spin resonance measurements of spin-labeled membranes of intact cells. Evidence has been obtained that liposomal lipids are either taken up by M14 cells or become incorporated in the cell membrane. The present data suggest the possibility that liposome treatments per se could be of potential value as a therapeutic approach, by increasing the effect of heat therapy

Enhancement of hyperthermic damage on M14 melanoma cells by liposome pretreatment

Exponentially growing human melanoma cells (M14 cell line) were pretreated with various amounts of dipalmitoylphosphatidylcholine-containing multilamellar liposomes and then exposed to heat treatment (42.5 degrees C). Cell damage produced by the treatments, given separately or in combination, was evaluated in terms of cell survival. Our results demonstrate that the cell survival at 37 degrees C was not affected by liposome concentrations up to 1000 nmol of phospholipid/2.5 x 10(6) cells, while liposome treatment of cells before heat exposure determined a marked damaging effect even at 100 nmol of phospholipid/2.5 x 10(6) cells. The mechanisms of liposome-cell interaction have been investigated by electron microscopy or by electron spin resonance measurements of spin-labeled membranes of intact cells. Evidence has been obtained that liposomal lipids are either taken up by M14 cells or become incorporated in the cell membrane. The present data suggest the possibility that liposome treatments per se could be of potential value as a therapeutic approach, by increasing the effect of heat therapy