Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation.

Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently been shown to correlate with blood folate. Since blood sampling and collection of 24 hour urine are cumbersome, we investigated whether the determination of urinary folate catabolites in fasted spot urine is a suitable non-invasive biomarker for folate status in subjects before and during folic acid supplementation. Immediate effects of oral folic acid bolus intake on urinary folate catabolites were assessed in a short-term pre-study. In the main study we included 53 healthy men. Of these, 29 were selected for a 12 week folic acid supplementation (400 µg). Blood, 24 hour and spot urine were collected at baseline and after 6 and 12 weeks and PF, RCF, urinary apABG and pABG were determined. Intake of a 400 µg folic acid bolus resulted in immediate increase of urinary catabolites. In the main study pABG and apABG concentrations in spot urine correlated well with their excretion in 24 hour urine. In healthy men consuming habitual diet, pABG showed closer correlation with PF (rs = 0.676) and RCF (rs = 0.649) than apABG (rs = 0.264, ns and 0.543). Supplementation led to significantly increased folate in plasma and red cells as well as elevated urinary folate catabolites, while only pABG correlated significantly with PF (rs = 0.574) after 12 weeks. Quantification of folate catabolites in fasted spot urine seems suitable as a non-invasive alternative to blood or 24 hour urine analysis for evaluation of folate status in populations consuming habitual diet. In non-steady-state conditions (folic acid supplementation) correlations between folate marker (RCF, PF, urinary catabolites) decrease due to differing kinetics

Heavy Load Rollers in Logistic Systems

Wheels with polyurethane bandages are in common use in logistic systems with friction gear actuation. Many research projects have studied the mechanical construction of these heavy load wheels. The studies have been theoretical as well as experimental. Research interests at the department of machine elements include the wear in the presence of intermediate material on the contact area between the bandage surface and the contact surface on which the wheel rolls off. This problem, which is observed when examining this tribochemical system, has not been studied before. Within this project both one-phase intermediate materials such as sand, water, cutting-cooling-emulsion, metal splinters and two-phase intermediate materials such as sand/water and combinations of the latter were taken into consideration. In addition, the exposure of the bandage hardness, the cross linking agent of the polyurethane, the mechanical stress, and the slip are observed. The analysis of the experimental results indicates that friction gear actuators can be constructed abrasion-optimised, taking into account special interfering effects in the form of intermediate materials in the contact area

Prevention of Neural-Tube Defects with Periconceptional Folic Acid, Methylfolate, or Multivitamins?

Background/Aims: To review the main results of intervention trials which showed the efficacy of periconceptional folic acid-containing multivitamin and folic acid supplementation in the prevention of neural-tube defects (NTD). Methods and Results: The main findings of 5 intervention trials are known: (i) the efficacy of a multivitamin containing 0.36 mg folic acid in a UK nonrandomized controlled trial resulted in an 83-91% reduction in NTD recurrence, while the results of the Hungarian (ii) randomized controlled trial and (iii) cohort-controlled trial using a multivitamin containing 0.8 mg folic acid showed 93 and 89% reductions in the first occurrence of NTD, respectively. On the other hand, (iv) another multicenter randomized controlled trial proved a 71% efficacy of 4 mg folic acid in the reduction of recurrent NTD, while (v) a public health-oriented Chinese-US trial showed a 41-79% reduction in the first occurrence of NTD depending on the incidence of NTD. Conclusions: Translational application of these findings could result in a breakthrough in the primary prevention of NTD, but so far this is not widely applied in practice. The benefits and drawbacks of 4 main possible uses of periconceptional folic acid/multivitamin supplementation, i.e. (i) dietary intake, (ii) periconceptional supplementation, (iii) flour fortification, and (iv) the recent attempt for the use of combination of oral contraceptives with 6S-5-methytetrahydrofolate (methylfolate), are discussed. Obviously, prevention of NTD is much better than the frequent elective termination of pregnancies after prenatal diagnosis of NTD fetuses

Speaking to the people? Money, trust, and central bank legitimacy in the age of quantitative easing

Financial upheaval and unconventional monetary policies have made money a salient political issue. This provides a rare opportunity to study the under-appreciated role of monetary trust in the politics of central bank legitimacy which, for the first time in decades, appears fragile. While research on central bank communication with "the markets" abounds, little is known about if and how central bankers speak to "the people." A closer look at the issue immediately reveals a paradox: while a central bank's legitimacy hinges on it being perceived as acting in line with the dominant folk theory of money, this theory accords poorly with how money actually works. How central banks cope with this ambiguity depends on the monetary situation. Using the Bundesbank and the European Central Bank as examples, this paper shows that under inflationary macro-economic conditions, central bankers willingly nourished the folk-theoretical notion of money as a quantity under the direct control of the central bank. By contrast, the Bank of England’s recent refutation of the folk theory of money suggests that deflationary pressures and rapid monetary expansion have fundamentally altered the politics of monetary trust and central bank legitimacy.Die durch die Finanzkrise und die unkonventionellen Maßnahmen der Zentralbanken bewirkte Politisierung des Geldes erlaubt einen seltenen Einblick in den Zusammenhang zwischen Geldvertrauen und Zentralbanklegitimität. Die Kommunikation von Zentralbanken mit der breiten Öffentlichkeit – im Gegensatz zur gut erforschten Kommunikation mit Finanzmärkten bisher weitgehend vernachlässigt – sieht sich mit einem Dilemma konfrontiert. Einerseits hängt die Legitimität der Zentralbank davon ab, ob ihr Handeln den Maximen entspricht, die sich aus der in der Öffentlichkeit vorherrschenden Theorie des Geldes ableiten. Andererseits weicht diese Theorie in wichtigen Punkten von der tatsächlichen Funktionsweise des Geldsystems ab. Wie Zentralbanken mit diesem Dilemma umgehen, hängt von der allgemeinen geldpolitischen Situation ab. Anhand der Beispiele der Deutschen Bundesbank und der Europäischen Zentralbank wird argumentiert, dass Zentralbanker unter inflationären Bedingungen die Öffentlichkeit gerne in dem Glauben lassen, die Geldmenge sei vollständig von der Zentralbank kontrolliert. Die außergewöhnliche Initiative der Bank of England, die Öffentlichkeit von der Irrtümlichkeit dieser Vorstellung zu überzeugen, zeigt hingegen, dass deflationärer Druck und rapide geldpolitische Expansion das diskursive Verhältnis zwischen Geldvertrauen und Zentralbanklegitimität grundlegend verändert haben.1 Introduction 2 Money, trust and people Money: The political economy of money and (central) banking Trust: What does it mean to say that people have trust in money? People: Beyond methodological elitism 3 The folk theory of capitalist credit money The myth that all money is created equal (and thus non-hierarchical) The myth of banks as intermediaries and the myth of exogenous money 4 The politics of trust and legitimacy: From monetary restraint to monetary expansion Fighting inflation: The Bundesbank/ECB pretense of control over M3 Fighting deflation: The Bank of England’s insistence on non-control over M3 5 Conclusion Reference

Safe assemblages:thinking infrastructures beyond circulation in the times of SARS-CoV2

The ongoing covid-19 pandemic has prompted discussions, both politically and analytically, that frame its security problematic as an infrastructural dilemma that unfolds between the public health-related need for interrupting the movement of people and calls to keep economic processes of production, distribution and consumption going. Moving beyond this diagnosis, we argue that infrastructural responses to the crisis in the European Union have resulted in the creation and invocation of economic and socio-material assemblages that are expected to steer societies through the crisis, which we term ‘safe assemblages’. In empirical terms, we discuss the cases of the creation of economic emergency funds which we view as economic assemblages that guarantee payment connectivity for struggling businesses, and of the invocation of the ‘home’ as an assemblage that minimises contagion risks while maintaining social connectivity through digital means. In theoretical terms, we suggest expanding current theorisations of the role of circulation in security infrastructures, referring to Foucault, by a consideration of assemblages as a third component that mediates the relationship between circulation and its interruption

Heavy Load Rollers in Logistic Systems

Wheels with polyurethane bandages are in common use in logistic systems with friction gear actuation. Many research projects have studied the mechanical construction of these heavy load wheels. The studies have been theoretical as well as experimental. Research interests at the department of machine elements include the wear in the presence of intermediate material on the contact area between the bandage surface and the contact surface on which the wheel rolls off. This problem, which is observed when examining this tribochemical system, has not been studied before. Within this project both one-phase intermediate materials such as sand, water, cutting-cooling-emulsion, metal splinters and two-phase intermediate materials such as sand/water and combinations of the latter were taken into consideration. In addition, the exposure of the bandage hardness, the cross linking agent of the polyurethane, the mechanical stress, and the slip are observed. The analysis of the experimental results indicates that friction gear actuators can be constructed abrasion-optimised, taking into account special interfering effects in the form of intermediate materials in the contact area.</jats:p