Highly Improved Naive and Staggered Fermions

We present a new action for highly improved staggered fermions. We show that perturbative calculations for the new action are well-behaved where those of the conventional staggered action are badly behaved. We discuss the effects of the new terms in controlling flavor mixing, and discuss the design of operators for the action.Comment: Contribution to Lattice2001(improvement); 3 page

Direct current control of three magnon scattering processes in spin-valve nanocontacts

We have investigated the generation of spin waves in the free layer of an extended spin-valve structure with a nano-scaled point contact driven by both microwave and direct electric current using Brillouin light scattering microscopy. Simultaneously with the directly excited spin waves, strong nonlinear effects are observed, namely the generation of eigenmodes with integer multiple frequencies (2 \emph{f}, 3 \emph{f}, 4 \emph{f}) and modes with non-integer factors (0.5 \emph{f}, 1.5 \emph{f}) with respect to the excitation frequency \emph{f}. The origin of these nonlinear modes is traced back to three magnon scattering processes. The direct current influence on the generation of the fundamental mode at frequency \emph{f} can be related to the spin-transfer torque, while the efficiency of three-magnon-scattering processes is controlled by the Oersted field as an additional effect of the direct current

Quantized spin wave modes in magnetic tunnel junction nanopillars

We present an experimental and theoretical study of the magnetic field dependence of the mode frequency of thermally excited spin waves in rectangular shaped nanopillars of lateral sizes 60x100, 75x150, and 105x190 nm2, patterned from MgO-based magnetic tunnel junctions. The spin wave frequencies were measured using spectrally resolved electrical noise measurements. In all spectra, several independent quantized spin wave modes have been observed and could be identified as eigenexcitations of the free layer and of the synthetic antiferromagnet of the junction. Using a theoretical approach based on the diagonalization of the dynamical matrix of a system of three coupled, spatially confined magnetic layers, we have modeled the spectra for the smallest pillar and have extracted its material parameters. The magnetization and exchange stiffness constant of the CoFeB free layer are thereby found to be substantially reduced compared to the corresponding thin film values. Moreover, we could infer that the pinning of the magnetization at the lateral boundaries must be weak. Finally, the interlayer dipolar coupling between the free layer and the synthetic antiferromagnet causes mode anticrossings with gap openings up to 2 GHz. At low fields and in the larger pillars, there is clear evidence for strong non-uniformities of the layer magnetizations. In particular, at zero field the lowest mode is not the fundamental mode, but a mode most likely localized near the layer edges.Comment: 16 pages, 4 figures, (re)submitted to PR

Filtering Solid Gabor Noise

International audienceSolid noise is a fundamental tool in computer graphics. Surprisingly, no existing noise function supports both high-quality antialiasing and continuity across sharp edges. In this paper we show that a slicing approach is required to preserve continuity across sharp edges, and we present a new noise function that supports anisotropic filtering of sliced solid noise. This is made possible by individually filtering the slices of Gabor kernels, which requires the proper treatment of phase. This in turn leads to the introduction of the phase-augmented Gabor kernel and random-phase Gabor noise, our new noise function. We demonstrate that our new noise function supports both high-quality anti-aliasing and continuity across sharp edges, as well as anisotropy

A consistent derivation of the quark--antiquark and three quark potentials in a Wilson loop context

In this paper we give a new derivation of the quark-antiquark potential in the Wilson loop context. This makes more explicit the approximations involved and enables an immediate extension to the three-quark case. In the $q\overline{q}$ case we find the same semirelativistic potential obtained in preceding papers but for a question of ordering. In the $3q$ case we find a spin dependent potential identical to that already derived in the literature from the ad hoc and non correct assumption of scalar confinement. Furthermore we obtain the correct form of the spin independent potential up to the $1/m^2$ order.Comment: 30 pages, Revtex (3 figures available as hard copies only), IFUM 452/F

Bethe--Salpeter equation in QCD

We extend to regular QCD the derivation of a confining $q \bar{q}$ Bethe--Salpeter equation previously given for the simplest model of scalar QCD in which quarks are treated as spinless particles. We start from the same assumptions on the Wilson loop integral already adopted in the derivation of a semirelativistic heavy quark potential. We show that, by standard approximations, an effective meson squared mass operator can be obtained from our BS kernel and that, from this, by ${1\over m^2}$ expansion the corresponding Wilson loop potential can be reobtained, spin--dependent and velocity--dependent terms included. We also show that, on the contrary, neglecting spin--dependent terms, relativistic flux tube model is reproduced.Comment: 23 pages, revte

Drug Development for Rare Paediatric Epilepsies: Current State and Future Directions

Rare diseases provide a challenge in the evaluation of new therapies. However, orphan drug development is of increasing interest because of the legislation enabling facilitated support by regulatory agencies through scientific advice, and the protection of the molecules with orphan designation. In the landscape of the rare epilepsies, very few syndromes, namely Dravet syndrome, Lennox-Gastaut syndrome and West syndrome, have been subject to orphan drug development. Despite orphan designations for rare epilepsies having dramatically increased in the past 10 years, the number of approved drugs remains limited and restricted to a handful of epilepsy syndromes. In this paper, we describe the current state of orphan drug development for rare epilepsies. We identified a large number of compounds currently under investigation, but mostly in the same rare epilepsy syndromes as in the past. A rationale for further development in rare epilepsies could be based on the match between the drug mechanisms of action and the knowledge of the causative gene mutation or by evidence from animal models. In case of the absence of strong pathophysiological hypotheses, exploratory/basket clinical studies could be helpful to identify a subpopulation that may benefit from the new drug. We provide some suggestions for future improvements in orphan drug development such as promoting paediatric drug investigations, better evaluation of the incidence and the prevalence, together with the natural history data, and the development of new primary outcomes

Comment on ``Evidence Against Instanton Dominance of Topological Charge Fluctuations in QCD''

We comment on the recent paper (hep-lat/0102003) by Horvath, Isgur, McCune, and Thacker, which concludes that the local chiral structure of fermionic eigenmodes is not consistent with instanton dominance. Our calculations, done with an overlap action, suggest the opposite conclusion.Comment: 5 pages, Revtex, 4 postscript figures. COLO-HEP-45