Comparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Rats

ΔΕΝ ΔΙΑΤΙΘΕΤΑΙ ΠΕΡΙΗΨΗIn this study, we aimed to compare the protective effects of melatonin and amifostine on radiation-induced oxidative stress. Fifty female Wistar rats (3-4 months old, weighing 200±25 g) were divided into five groups (with ten rats each) and treated as follows: control (Cont), radiotherapy alone (RT), radiotherapy + amifostine (RT+AMI), radiotherapy + melatonin (RT+MEL), radiotherapy + amifostine + melatonin (RT+AMI+MEL). Rats were irradiated individually with a single dose of 8 Gy and amifostine (200 mg/kg) and melatonin (10 mg/kg) was administered to rats 30 minutes before irradiation. At the end of this follow-up period (72 hours) the rats were sacrificed. Spectrophotometric Analysis has been performed to kidney tissue samples. As a result of statistical comparison between groups after RT, total antioxidant capacity (TAC) decreased, total oxidant status (TOS) and oxidative stress index (OSI) increased, although the statistically significant change was only for OSI (p = 0.030). Addition of AMI or MEL to RT increased TAC and OSI significantly (p = 0.000), but there was no additive effect for TAC and OSI when both drugs were given together (p = 1.000, p = 0.172, respectively). In terms of TOS, statistically significant increasing was only for AMI (p = 0.000). There was protective effect when both drugs were given together against on Radiation-Induced Renal Oxidative Stress

A Comparison of H8-Synthesis and Feedback Linearization for Rotary Inverted Pendulum

11th International Conference on Mechanical and Aerospace Engineering (2020 : Athens; Greece)This paper investigates the performance comparison of H8 based control and feedback linearization. The comparison is conducted on a challenging rotary inverted pendulum (RIP) system. The main difficulty of controlling RIP is the existence of RHP poles and zeros. Since the plant does not satisfy the typical H8 control design conditions, a transformation of the location of RHP zeros is employed which put the system in a desired/solvable form. The existence of unstable internal dynamic states also causes some problems in the design of feedback linearization. These problems is solved by employing an outer loop cascade control scheme. The theoretical backgrounds and the design steps for the specific problem are listed. The designed controllers are tested on the nonlinear model whose parameters are perturbed to test the robustness of the controllers. The results of the Monte Carlo simulations are presented and findings are discussed. © 2020 IEEE