836 research outputs found
Enhancing industrial vertical falling film evaporation through modification of heat transfer surfaces β an experimental study
In this study we introduce and experimentally study modifications of heat transfer surfaces as a means to improve the heat transfer in evaporative vertical falling film units. We look at two modified tubular surfaces and compare the obtained results to those acquired using a similar smooth surface. We carry out experiments with two fluids of significantly different viscosities and work with a broad range of industrially relevant operating conditions, with Kapitza (Ka) and Reynolds (Re) numbers in the range of Ka = 500β10 000 and Re = 100β2 000, respectively. We find that the heat transfer rate in a pilot-scale unit can be improved by 50% to more than 100%, depending on geometrical features (e.g. sharpness) of the modified surface. Our results pave the way for increasing the overall efficiency of industrial evaporation plants by increasing the energy intensity of the evaporator per unit area through carefully tailored modifications of heat transfer surfaces
Effect of viscosity on droplet-droplet collisional interaction
A complete knowledge of the effect of droplet viscosity on droplet-droplet collision outcomes is essential for industrial processes such as spray drying. When droplets with dispersed solids are dried, the apparent viscosity of the dispersed phase increases by many orders of magnitude, which drastically changes the outcome of a droplet-droplet collision. However, the effect of viscosity on the droplet collision regime boundaries demarcating coalescence and reflexive and stretching separation is still not entirely understood and a general model for collision outcome boundaries is not available. In this work, the effect of viscosity on the droplet-droplet collision outcome is studied using direct numerical simulations employing the volume of fluid method. The role of viscous energy dissipation is analysed in collisions of droplets with different sizes and different physical properties. From the simulations results, a general phenomenological model depending on the capillary number (Ca, accounting for viscosity), the impact parameter (B), the Weber number (We), and the size ratio (Ξ) is proposed
Digestive Duet: Midgut Digestive Proteinases of Manduca sexta Ingesting Nicotiana attenuata with Manipulated Trypsin Proteinase Inhibitor Expression
The defensive effect of endogenous trypsin proteinase inhibitors (NaTPIs) on the herbivore Manduca sexta was demonstrated by genetically altering NaTPI production in M. sexta's host plant, Nicotiana attenuata. To understand how this defense works, we studied the effects of NaTPI on M. sexta gut proteinase activity levels in different larval instars of caterpillars feeding freely on untransformed and transformed plants. Methodology/ Principal Findings Second and third instars larvae that fed on NaTPI-producing (WT) genotypes were lighter and had less gut proteinase activity compared to those that fed on genotypes with either little or no NaTPI activity. Unexpectedly, NaTPI activity in vitro assays not only inhibited the trypsin sensitive fraction of gut proteinase activity but also halved the NaTPI-insensitive fraction in third-instar larvae. Unable to degrade NaTPI, larvae apparently lacked the means to adapt to NaTPI in their diet. However, caterpillars recovered at least part of their gut proteinase activity when they were transferred from NaTPI-producing host plants to NaTPI-free host plants. In addition extracts of basal leaves inhibited more gut proteinase activity than did extracts of middle stem leaves with the same protein content. Conclusions/ Significance Although larvae can minimize the effects of high NaTPI levels by feeding on leaves with high protein and low NaTPI activity, the host plant's endogenous NaTPIs remain an effective defense against M. sexta, inhibiting gut proteinase and affecting larval performance
Enamel reduction techniques in orthodontics:a literature review
Artificial abrasion of interproximal surfaces has been described for almost seventy years as orthodontic intervention for achievement and maintenance of ideal treatment outcome. A variety of terms and approaches have been introduced throughout this period implying a growing clinicians' interest. Nevertheless, the widespread recognition of enamel stripping technique was initiated by the advent of bonded orthodontic attachments and a 2-article series of Sheridan in the 80's. Since then, experimental and clinical research has been focused on the investigation of instrumentation efficacy and potential iatrogenic sequelae related to interproximal stripping. This review discusses the evolution, technical aspects and trends of enamel reduction procedures as documented in the literature
In vivo biofilm formation on stainless steel bonded retainers during different oral health-care regimens
Retention wires permanently bonded to the anterior teeth are used after orthodontic treatment to prevent the teeth from relapsing to pre-treatment positions. A disadvantage of bonded retainers is biofilm accumulation on the wires, which produces a higher incidence of gingival recession, increased pocket depth and bleeding on probing. This study compares in vivo biofilm formation on single-strand and multi-strand retention wires with different oral health-care regimens. Two-centimetre wires were placed in brackets that were bonded to the buccal side of the first molars and second premolars in the upper arches of 22 volunteers. Volunteers used a selected toothpaste with or without the additional use of a mouthrinse containing essential oils. Brushing was performed manually. Regimens were maintained for 1 week, after which the wires were removed and the oral biofilm was collected to quantify the number of organisms and their viability, determine the microbial composition and visualize the bacteria by electron microscopy. A 6-week washout period was employed between regimens. Biofilm formation was reduced on single-strand wires compared with multi-strand wires; bacteria were observed to adhere between the strands. The use of antibacterial toothpastes marginally reduced the amount of biofilm on both wire types, but significantly reduced the viability of the biofilm organisms. Additional use of the mouthrinse did not result in significant changes in biofilm amount or viability. However, major shifts in biofilm composition were induced by combining a stannous fluoride- or triclosan-containing toothpaste with the mouthrinse. These shifts can be tentatively attributed to small changes in bacterial cell surface hydrophobicity after the adsorption of the toothpaste components, which stimulate bacterial adhesion to the hydrophobic oil, as illustrated for a Streptococcus mutans strain
An experimental study of droplet-particle collisions
When spray drying a liquid slurry such as milk, collisions between droplets, partially dried particles and completely dry particles are important because coalescence, agglomeration and breakup events influence the size and morphology of the produced powder. When modelling such a spray drying process, it is therefore important to be able to predict the outcomes of individual binary collisions. Both binary dry particle collisions and binary droplet collisions have individually been thoroughly researched over the years due to their widespread occurrence. The importance of understanding binary particle-droplet collisions has been emphasized more recently. However, the number of available studies is limited and simulation studies usually focus on relatively high capillary number. A theory explaining the transition between different regimes is still lacking. The goal of this study is to provide an experimental data set at low capillary number. These results can be used to validate future theories and simulations. To produce and record particle-droplet collisions, an experimental setup that enables synchronized release of both a particle and a droplet was used. One single hanging droplet was released from above onto a particle that initially was held in place by vacuum suction. A high speed camera was synchronized with the setup, and recorded the collisions. Image files were then analysed in Matlab to find velocities and sizes of the particle and droplet before and after impact. The contrast of particle and droplet against the illuminated background was a key factor in succeeding with this. Different collision outcomes were identified as either agglomeration (merging), where the whole droplet would stick to the surface of the particle, or a stretching separation (breaking), where the droplet collides with the particle in an oblique position and stretches out until a part of the droplet detaches from the liquid sticking to the particle. The formation of satellite droplets, i.e. droplets with a radius significantly smaller than the leaving droplet, was also detected. The relation of these collision outcomes to impact conditions such as Weber number and impact parameter was reviewed and put into regime maps
Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat
One of the functions of group 11 metabotropic glutamate receptors (mGluR2/3) is to modulate glutamate release. Thus, targeting mGluR2/3s might be a novel treatment for several psychiatric disorders associated with inappropriate glutamatergic neurotransmission, such as schizophrenia. In an effort to evaluate the antipsychotic properties of LY379268; a potent and selective mGluR2/3 agonist, we examined its effect on ketamine-evoked hyperlocomotion and sensorimotor gating deficit (PPI) in rats, an animal model of schizophrenia. We also measured the ex vivo tissue level of glutamate (Glu), dopamine (DA) and serotonin (5-HT) as well as the DA metabolites DOPAC and the major 5-HT metabolite HIAA to determine the neurochemical effects of ketamine (12 mg/kg) and LY379268 (1 mg/kg) in the dentate gyrus (DG). While LY379268 (1-3 mg/kg) reduced ketamine-evoked hyperlocomotion (12 mg/kg), it could not restore ketamine-evoked PPI deficits (4-12 mg/kg). In the DG we found that ketamine decreased Glu and DA levels, as well as HIAA/5-HT turnover, and that LY379268 could prevent ketamine effects on Glu level but not on monoamine transmission. These results may indicate that the inability of LY379268 to reverse PPI deficits is attributable to its lack of effect on ketamine-induced changes in monoamine transmission, but that LY379268 can prevent ketamine-evoked changes in glutamate, which is sufficient to block hyperlocomotion. In addition to the partial effectiveness of LY379268 in the ketamine model of schizophrenia, we observed a dual effect of LY379268 on anxious states, whereby a low dose of this compound (1 mg/kg) produced anxiolytic effects, while a higher dose (3 mg/kg) appeared to be anxiogenic. Additional work is needed to address a possible role of LY379268 in schizophrenia and anxiety treatment. (c) 2006 Elsevier Inc. All rights reserved
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