Oxidation of linear alcohols with hydrogen peroxide over titanium silicate-1

Abatract In this paper different parameters affecting the oxidation of alcohols with hydrogen peroxide are described. The influence of the amount and of the crystallite size of the catalyst, as well as the concentrations of hydrogen peroxide and substrate have been studied. The influence of the reaction temperature, the chain length of the alcohol (C6, C7, C8 and C9 ) and the position of the alcohol group (a, /3 or y) on the reaction rate has also been investigated. As a result of this study it can be reported that the reaction is first order with respect to the amount of catalyst and the hydrogen peroxide concentration, and zero order in alcohol concentration. The activation energy for the oxidation of 2-octanol is 71 kJ/ mol. The particle size has a considerable effect on the reaction rate; larger particles result slower reaction. There is a remarkable effect of the chain length on the reaction rate (C6<C7<C8% C9) and the position of the hydroxyl group has a strong effect on the activity of TS-1 (fl> (Y > y ) . The crystallite size effect can be explained by means of diffusion limitations, as could be illustrated by Weisz modulus calculations. The observed difference in activity between jI and y alcohols can not be related to differences in diffusion (single component diffusion of /I and y alcohols show little difference) and therefore transition state restrictions of the alcohols in the pores of the TS-1 may be a possible explanation for this effect

Aromatization of propane over MFI-gallosilicates

Abstract The results of propane aromatization over gallium containing HZSM-5 zeolites are described. H ighlx dispersed gallium in the zeolite I framework or extra-framework ) was fl)und to possess dehydrogenation activity, especially in the presence of strong Bronsted acid sites. The extra-framework gallium was introduced by mildly steaming a H-I Ga )ZSM-5 zeolite or by physically mixing Ga:O~ or a GAPSO-11 molecular sieve with H-c AI )ZSM-5. The higher dehydrogenation rates in the presence of gallium facilitated the formation of carbonaceous products, resulting in higher deactivation rates. A mechanism fi)r hydrogen fl)rmation is discussed

Применение генетического алгоритма в задачах адаптации структур данных

Представлена разработанная схема адаптации структур данных в оперативной памяти. Для поиска адаптированной структуры данных предложено применение генетического алгоритма. Определены его особенности. Для растровых изображений с соответствующими заголовками выполнены экспериментальные исследования временной эффективности адаптированных структур данных, времени сходимости генетического алгоритма и условия целесообразности применения адаптации.Представлена розроблена схема адаптації структур даних в оперативній пам’яті. Для пошуку адаптованої структури даних запропоновано застосування генетичного алгоритму. Визначені його особливості. Для растрових зображень з відповідними заголовками виконані експериментальні дослідження часової ефективності адаптованих структур даних, часу збіжності генетичного алгоритму та умови доцільності застосування адаптації.The developed scheme of data structures adaptation in memory is given. To search for an adapted data structure, genetic algorithm is proposed and its characteristics are defined. For raster images with the appropriate headings, experimental studies of the time efficiency of adapted data structures, the convergence time of the genetic algorithm and conditions for feasibility of adapting are performed

Structural Susceptibility and Separation of Time Scales in the van der Pol Oscillator

We use an extension of the van der Pol oscillator as an example of a system with multiple time scales to study the susceptibility of its trajectory to polynomial perturbations in the dynamics. A striking feature of many nonlinear, multi-parameter models is an apparently inherent insensitivity to large magnitude variations in certain linear combinations of parameters. This phenomenon of "sloppiness" is quantified by calculating the eigenvalues of the Hessian matrix of the least-squares cost function which typically span many orders of magnitude. The van der Pol system is no exception: Perturbations in its dynamics show that most directions in parameter space weakly affect the limit cycle, whereas only a few directions are stiff. With this study we show that separating the time scales in the van der Pol system leads to a further separation of eigenvalues. Parameter combinations which perturb the slow manifold are stiffer and those which solely affect the transients in the dynamics are sloppier.Comment: 7 pages, 4 figure

Association of time-updated plasma calcium and phosphate with graft and patient outcomes after kidney transplantation

Disturbances in calcium-phosphate homeostasis are common after kidney transplantation. We aimed to assess the relationship between deregulations in plasma calcium and phosphate over time and mortality and death-censored graft failure (DCGF). In this prospective cohort study we included kidney transplant recipients with ≥2 plasma calcium and phosphate measurements. Data were analyzed using time-updated Cox regression analyses adjusted for potential confounders including time-updated kidney function. We included 2,769 patients (mean age 47±14 years, 42.3% female) with 138,496 plasma calcium and phosphate levels (median [IQR] 43 [31-61] measurements per patient). During follow-up of 16.3 [8.7-25.2] years, 17.2% developed DCGF and 7.9% died. Post-transplant hypercalcemia was associated with an increased risk of mortality (1.63 [1.31-2.00], P<0.0001), but not DCGF. Hyperphosphatemia was associated with both DCGF (2.59 [2.05-3.27], P<0.0001) and mortality (3.14 [2.58-3.82], P<0.0001). Only the association between hypercalcemia and mortality remained significant in sensitivity analyses censored by a simultaneous eGFR <45 mL/min/1.73 m2 . Hypocalcemia and hypophosphatemia were not consistently associated with either outcome. Post-transplant hypercalcemia, even in the presence of preserved kidney function, was associated with an increased mortality risk. Associations of hyperphosphatemia with DCGF and mortality may be driven by eGFR

Variational approach to a class of nonlinear oscillators with several limit cycles

We study limit cycles of nonlinear oscillators described by the equation $\ddot x + \nu F(\dot x) + x =0$. Depending on the nonlinearity this equation may exhibit different number of limit cycles. We show that limit cycles correspond to relative extrema of a certain functional. Analytical results in the limits $\nu ->0$ and $\nu -> \infty$ are in agreement with previously known criteria. For intermediate $\nu$ numerical determination of the limit cycles can be obtained.Comment: 12 pages, 3 figure

LiMeS-Lab:An Integrated Laboratory for the Development of Liquid–Metal Shield Technologies for Fusion Reactors

The liquid metal shield laboratory (LiMeS-Lab) will provide the infrastructure to develop, test, and compare liquid metal divertor designs for future fusion reactors. The main research topics of LiMeS-lab will be liquid metal interactions with the substrate material of the divertor, the continuous circulation and capillary refilling of the liquid metal during intense plasma heat loading and the retention of plasma particles in the liquid metal. To facilitate the research, four new devices are in development at the Dutch Institute for Fundamental Energy Research and the Eindhoven University of Technology: LiMeS-AM: a custom metal 3D printer based on powder bed fusion; LiMeS-Wetting, a plasma device to study the wetting of liquid metals on various substrates with different surface treatments; LiMeS-PSI, a linear plasma generator specifically adapted to operate continuous liquid metal loops. Special diagnostic protection will also be implemented to perform measurements in long duration shots without being affected by the liquid metal vapor; LiMeS-TDS, a thermal desorption spectroscopy system to characterize deuterium retention in a metal vapor environment. Each of these devices has specific challenges due to the presence and deposition of metal vapors that need to be addressed in order to function. In this paper, an overview of LiMeS-Lab will be given and the conceptual designs of the last three devices will be presented.</p

Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells

The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has an enormous impact on human health and economy. In search for therapeutic options, researchers have proposed resveratrol, a food supplement with known antiviral, anti-inflammatory, and antioxidant properties as an advantageous antiviral therapy for SARS-CoV-2 infection. Here, we provide evidence that both resveratrol and its metabolically more stable structural analog, pterostilbene, exhibit potent antiviral properties against SARS-CoV-2 in vitro. First, we show that resveratrol and pterostilbene antiviral activity in African green monkey kidney cells. Both compounds actively inhibit virus replication within infected cells as reduced virus progeny production was observed when the compound was added at post-inoculation conditions. Without replenishment of the compound, antiviral activity was observed up to roughly five rounds of replication, demonstrating the long-lasting effect of these compounds. Second, as the upper respiratory tract represents the initial site of SARS-CoV-2 replication, we also assessed antiviral activity in air–liquid interface (ALI) cultured human primary bronchial epithelial cells, isolated from healthy volunteers. Resveratrol and pterostilbene showed a strong antiviral effect in these cells up to 48 h post-infection. Collectively, our data indicate that resveratrol and pterostilbene are promising antiviral compounds to inhibit SARS-CoV-2 infection. Because these results represent laboratory findings in cells, we advocate evaluation of these compounds in clinical trials before statements are made whether these drugs are advantageous for COVID-19 treatment

Evaluation of effective resistances in pseudo-distance-regular resistor networks

In Refs.[1] and [2], calculation of effective resistances on distance-regular networks was investigated, where in the first paper, the calculation was based on the stratification of the network and Stieltjes function associated with the network, whereas in the latter one a recursive formula for effective resistances was given based on the Christoffel-Darboux identity. In this paper, evaluation of effective resistances on more general networks called pseudo-distance-regular networks [21] or QD type networks \cite{obata} is investigated, where we use the stratification of these networks and show that the effective resistances between a given node such as $\alpha$ and all of the nodes $\beta$ belonging to the same stratum with respect to $\alpha$ ($R_{\alpha\beta^{(m)}}$, $\beta$ belonging to the $m$-th stratum with respect to the $\alpha$) are the same. Then, based on the spectral techniques, an analytical formula for effective resistances $R_{\alpha\beta^{(m)}}$ such that $L^{-1}_{\alpha\alpha}=L^{-1}_{\beta\beta}$ (those nodes $\alpha$, $\beta$ of the network such that the network is symmetric with respect to them) is given in terms of the first and second orthogonal polynomials associated with the network, where $L^{-1}$ is the pseudo-inverse of the Laplacian of the network. From the fact that in distance-regular networks, $L^{-1}_{\alpha\alpha}=L^{-1}_{\beta\beta}$ is satisfied for all nodes $\alpha,\beta$ of the network, the effective resistances $R_{\alpha\beta^{(m)}}$ for $m=1,2,...,d$ ($d$ is diameter of the network which is the same as the number of strata) are calculated directly, by using the given formula.Comment: 30 pages, 7 figure