Phototesting and photoprotection in LE

Photosensitivity and induction of skin lesions following UV radiation is a common problem of patients with cutaneous and systemic forms of lupus erythematosus. The detrimental effect of UV radiation to patients with lupus erythematosus was already recognized in the last century. Skin lesions can now be provoked under standardized conditions allowing the diagnosis and classification of patients with photosensitive disorders. The aim of this review is to give an overview on the history, test procedure and test results in patients with lupus erythematosus

A Partial Read Barrier for Efficient Support of Live Object-oriented Programming

International audienceLive programming, originally introduced by Smalltalk and Lisp, and now gaining popularity in contemporary systems such as Swift, requires on-the-fly support for object schema migration, such that the layout of objects may be changed while the program is at one and the same time being run and developed. In Smalltalk schema migration is supported by two primitives, one that answers a collection of all instances of a class, and one that exchanges the identities of pairs of objects, called the become primitive. Existing instances are collected, copies using the new schema created, state copied from old to new, and the two exchanged with become, effecting the schema migration. Historically the implementation of become has either required an extra level of indirection between an object's address and its body, slowing down slot access, or has required a sweep of all objects, a very slow operation on large heaps. Spur, a new object representation and memory manager for Smalltalk-like languages, has neither of these deficiencies. It uses direct pointers but still provides a fast become operation in large heaps, thanks to forwarding objects that when read conceptually answer another object and a partial read barrier that avoids the cost of explicitly checking for forwarding objects on the vast majority of object accesses

Link-time static analysis for efficient separate compilation of object-oriented languages

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Sindarin: A Versatile Scripting API for the Pharo Debugger

International audienceDebugging is one of the most important and time consuming activities in software maintenance, yet mainstream debuggers are not well-adapted to several debugging scenarios. This has led to the research of new techniques covering specific families of complex bugs. Notably, recent research proposes to empower developers with scripting DSLs, plugin-based and moldable debuggers. However, these solutions are tailored to specific use-cases, or too costly for one-time-use scenarios. In this paper we argue that exposing a debugging scripting interface in mainstream debuggers helps in solving many challenging debugging scenarios. For this purpose, we present Sindarin, a scripting API that eases the expression and automation of different strategies developers pursue during their debugging sessions. Sindarin provides a GDB-like API, augmented with AST-bytecode-source code mappings and object-centric capabilities. To demonstrate the versatility of Sindarin, we reproduce several advanced breakpoints and non-trivial debugging mechanisms from the literature

JavaScript AOT compilation

International audienceStatic compilation, a.k.a., ahead-of-time (AOT) compilation, is an alternative approach to JIT compilation that can combine good speed and lightweight memory footprint, and that can accommodate read-only memory constraints that are imposed by some devices and some operating systems. Unfortunately the highly dynamic nature of JavaScript makes it hard to compile statically and all existing AOT compilers have either gave up on good performance or full language support. We have designed and implemented an AOT compiler that aims at satisfying both. It supports full unrestricted ECMAScript 5.1 plus many ECMAScript 2017 features and the majority of benchmarks are within 50% of the performance of one of the fastest JIT compilers

Test of the Kolmogorov-Johnson-Mehl-Avrami picture of metastable decay in a model with microscopic dynamics

The Kolmogorov-Johnson-Mehl-Avrami (KJMA) theory for the time evolution of the order parameter in systems undergoing first-order phase transformations has been extended by Sekimoto to the level of two-point correlation functions. Here, this extended KJMA theory is applied to a kinetic Ising lattice-gas model, in which the elementary kinetic processes act on microscopic length and time scales. The theoretical framework is used to analyze data from extensive Monte Carlo simulations. The theory is inherently a mesoscopic continuum picture, and in principle it requires a large separation between the microscopic scales and the mesoscopic scales characteristic of the evolving two-phase structure. Nevertheless, we find excellent quantitative agreement with the simulations in a large parameter regime, extending remarkably far towards strong fields (large supersaturations) and correspondingly small nucleation barriers. The original KJMA theory permits direct measurement of the order parameter in the metastable phase, and using the extension to correlation functions one can also perform separate measurements of the nucleation rate and the average velocity of the convoluted interface between the metastable and stable phase regions. The values obtained for all three quantities are verified by other theoretical and computational methods. As these quantities are often difficult to measure directly during a process of phase transformation, data analysis using the extended KJMA theory may provide a useful experimental alternative.Comment: RevTex, 21 pages including 14 ps figures. Submitted to Phys. Rev. B. One misprint corrected in Eq.(C1

Measurement of electron beam transverse flux density distribution

The work presents experimental measurements of electron beam transverse flux density distribution. Experimental data is recorded during the multiple beam scanning in different directions with the particular angle step by the thin scintillation strip. The intensity of the light generated in the scintillator is proportional to the intensity of the radiation going through the strip. Generated photons is guided by the optical fiber to the photomultiplier and registered by the analyzer. The result of the work is the experimental data demonstrated dependence of the radiation intensity on detecting strip position and angle orientation. This dependence is transformed to the radiation intensity dependence on the coordinates in the beam transverse plane using special mathematical processing