Estimation of glottal closure instants in voiced speech using the DYPSA algorithm

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Gauge Coupling Unification via A Novel Technicolor Model

We show that the recently proposed minimal walking technicolor theory together with a small modification of the Standard Model fermionic matter content leads to an excellent degree of unification of the gauge couplings. We compare the degree of unification with various time-honored technicolor models and the minimal supersymmetric extension of the Standard Model. We find that, at the one-loop level, the new theory provides a degree of unification higher than any of the other extensions above. The phenomenology of the present model is very rich with various potential dark matter candidates.Comment: Final version to match the published on

Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses

<p>Background: Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart disease risk.</p> <p>Design: Prospective case-control study, systematic review and meta-analyses.</p> <p>Methods: Measurements were made in 1925 people who had a first-ever nonfatal myocardial infarction or died of coronary heart disease during follow-up (median 19.4 years) and in 3616 controls nested within the prospective population-based Reykjavik Study.</p> <p>Results: Age and sex-adjusted odds ratios for coronary heart disease per 1 standard deviation higher baseline level were 1.25 (1.18, 1.33) for t-PA antigen, 1.01 (0.95, 1.07) for D-dimer and 1.11 (1.05, 1.18) for VWF. After additional adjustment for conventional cardiovascular risk factors, corresponding odds ratios were 1.07 (0.99, 1.14) for t-PA antigen, 1.06 (1.00, 1.13) for D-dimer and 1.08 (1.02, 1.15) for VWF. When combined with the results from previous prospective studies in a random-effects meta-analysis, overall adjusted odds ratios were 1.13 (1.06, 1.21) for t-PA antigen (13 studies, 5494 cases), 1.23 (1.16, 1.32) with D-dimer (18 studies, 6799 cases) and 1.16 (1.10, 1.22) with VWF (15 studies, 6556 cases).</p> <p>Conclusions: Concentrations of t-PA antigen, D-dimer and VWF may be more modestly associated with first-ever CHD events than previously reported. More detailed analysis is required to clarify whether these markers are causal risk factors or simply correlates of coronary heart disease.</p&gt

Modes of the Sakai-Sugimoto soliton

The instanton in the Sakai-Sugimoto model corresponds to the Skyrmion on the holographic boundary - which is asymptotically flat - and is fundamentally different from the flat Minkowski space Yang-Mills instanton. We use the Atiyah-Patodi-Singer index theorem and a series of transformations to show that there are 6k zeromodes - or moduli - in the limit of infinite 't Hooft coupling of the Sakai-Sugimoto model. The implications for the low-energy baryons - the Skyrmions - on the holographic boundary, is a scale separation between 2k "heavy" massive modes and 6k-9 "light" massive modes for k>1; the 9 global transformations that correspond to translations, rotations and isorotations remain as zeromodes. For k=1 there are 2 "heavy" modes and 6 zeromodes due to degeneracy between rotations and isorotations.Comment: LaTeX: 14 pages, 3 figure

Zero-modes of Non-Abelian Solitons in Three Dimensional Gauge Theories

We study non-Abelian solitons of the Bogomol'nyi type in N=2 (d=2+1) supersymmetric Chern-Simons (CS) and Yang-Mills (YM) theory with a generic gauge group. In CS theory, we find topological, non-topological and semi-local (non-)topological vortices of non-Abelian kinds in unbroken, broken and partially broken vacua. We calculate the number of zero-modes using an index theorem and then we apply the moduli matrix formalism to realize the moduli parameters. For the topological solitons we exhaust all the moduli while we study several examples of the non-topological and semi-local solitons. We find that the zero-modes of the topological solitons are governed by the moduli matrix H_0 only and those of the non-topological solitons are governed by both H_0 and the gauge invariant field \Omega. We prove local uniqueness of the master equation in the YM case and finally, compare all results between the CS and YM theories.Comment: 54 pages, 1 figur

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review

Background The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations. We evaluated associations of long-term circulating IL-6 levels with CHD risk (defined as nonfatal myocardial infarction [MI] or fatal CHD) in two population-based cohorts, involving serial measurements to enable correction for within-person variability. We updated a systematic review to put the new findings in context. Methods and Findings Measurements were made in samples obtained at baseline from 2,138 patients who had a first-ever nonfatal MI or died of CHD during follow-up, and from 4,267 controls in two cohorts comprising 24,230 participants. Correction for within-person variability was made using data from repeat measurements taken several years apart in several hundred participants. The year-to-year variability of IL-6 values within individuals was relatively high (regression dilution ratios of 0.41, 95% confidence interval [CI] 0.28-0.53, over 4 y, and 0.35, 95% CI 0.23-0.48, over 12 y). Ignoring this variability, we found an odds ratio for CHD, adjusted for several established risk factors, of 1.46 (95% CI 1.29-1.65) per 2 standard deviation (SD) increase of baseline IL-6 values, similar to that for baseline C-reactive protein. After correction for within-person variability, the odds ratio for CHD was 2.14 (95% CI 1.45-3.15) with long-term average ("usual'') IL-6, similar to those for some established risk factors. Increasing IL-6 levels were associated with progressively increasing CHD risk. An updated systematic review of electronic databases and other sources identified 15 relevant previous population-based prospective studies of IL-6 and clinical coronary outcomes (i.e., MI or coronary death). Including the two current studies, the 17 available prospective studies gave a combined odds ratio of 1.61 (95% CI 1.42-1.83) per 2 SD increase in baseline IL-6 (corresponding to an odds ratio of 3.34 [95% CI 2.45-4.56] per 2 SD increase in usual [long-term average] IL-6 levels). Conclusions Long-term IL-6 levels are associated with CHD risk about as strongly as are some major established risk factors, but causality remains uncertain. These findings highlight the potential relevance of IL-6-mediated pathways to CH

Non-Abelian vortex dynamics: Effective world-sheet action

The low-energy vortex effective action is constructed in a wide class of systems in a color-flavor locked vacuum, which generalizes the results found earlier in the context of U(N) models. It describes the weak fluctuations of the non-Abelian orientational moduli on the vortex worldsheet. For instance, for the minimum vortex in SO(2N) x U(1) or USp(2N) x U(1) gauge theories, the effective action found is a two-dimensional sigma model living on the Hermitian symmetric spaces SO(2N)/U(N) or USp(2N)/U(N), respectively. The fluctuating moduli have the structure of that of a quantum particle state in spinor representations of the GNO dual of the color-flavor SO(2N) or USp(2N) symmetry, i.e. of SO(2N) or of SO(2N+1). Applied to the benchmark U(N) model our procedure reproduces the known CP(N-1) worldsheet action; our recipe allows us to obtain also the effective vortex action for some higher-winding vortices in U(N) and SO(2N) theories.Comment: LaTeX, 25 pages, 0 figure

Voice SourceWaveform Analysis and Synthesis Using Principal Component Analysis and Gaussian Mixture Modelling

The paper presents a voice source waveform modeling techniques based on principal component analysis (PCA) and Gaussian mixture modeling (GMM). The voice source is obtained by inverse-filtering speech with the estimated vocal tract filter. This decomposition is useful in speech analysis, synthesis, recognition and coding. Here, a data-driven approach is presented for signal decomposition and classification based on the principal components of the voice source. The principal components are analyzed and the 'prototype' voice source signals corresponding to the Gaussian mixture means are examined. We show how an unknown signal can be decomposed into its components and/or prototypes and resynthesized. We show how the techniques are suited for both low bitrate or high quality analysis/synthesis schemes

Group Theory of Non-Abelian Vortices

We investigate the structure of the moduli space of multiple BPS non-Abelian vortices in U(N) gauge theory with N fundamental Higgs fields, focusing our attention on the action of the exact global (color-flavor diagonal) SU(N) symmetry on it. The moduli space of a single non-Abelian vortex, CP(N-1), is spanned by a vector in the fundamental representation of the global SU(N) symmetry. The moduli space of winding-number k vortices is instead spanned by vectors in the direct-product representation: they decompose into the sum of irreducible representations each of which is associated with a Young tableau made of k boxes, in a way somewhat similar to the standard group composition rule of SU(N) multiplets. The K\"ahler potential is exactly determined in each moduli subspace, corresponding to an irreducible SU(N) orbit of the highest-weight configuration.Comment: LaTeX 46 pages, 4 figure