4,771 research outputs found

    The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi

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    Acknowledgements TG and CF are funded by FEDER funds through the Operational Programme Competitiveness Factors – COMPETE and national funds by FCT – Foundation for Science and Technology under the strategic project UID/NEU/04539/2013. C.F. is a recipient of a postdoctoral fellowship from FCT-Fundação para a Ciência e Tecnologia (SFRH/BPD/63733/2009). NG is funded by The Wellcome Trust (080088, 086827, 075470, 099215 & 097377), the FungiBrain Marie Curie Network and the Medical Research Council (UK).Peer reviewe

    Dissection of the Candida albicans class I chitin synthase promoters

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    We acknowledge financial support from the Biotechnology and Biological Sciences Research Council (10161), Medical Research Council (New Investigator Award to C.A.M.), the European Community FUNGALWALL and SIGNALPATH initiatives and the Wellcome Trust.Peer reviewedPublisher PD

    Information seeking in the Humanities: physicality and digitality

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    This paper presents a brief overview of a research project that is examining the information seeking practices of humanities scholars. The results of this project are being used to develop digital resources to better support these work activities. Initial findings from a recent set of interviews is offered, revealing the importance of physical artefacts in the humanities scholars’ research processes and the limitations of digital resources. Finally, further work that is soon to be undertaken is summarised, and it is hoped that after participation in this workshop these ideas will be refined

    FOOD SAFETY IN THE MEAT INDUSTRY: A REGULATORY QUAGMIRE

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    Food Consumption/Nutrition/Food Safety, Livestock Production/Industries,

    FIRMS, INCENTIVES, AND THE SUPPLY OF FOOD SAFETY: A FORMAL MODEL OF GOVERNMENT ENFORCEMENT

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    Recent instances of significant food safety breeches in both meat and biotechnology challenge traditional safety efforts. A formal model utilizing agency theory is used to explore the power relationships between the regulator and the firm. Fundamental issues effecting firms' supply of safety are demonstrated and alternative corrective mechanisms are discussed.Food Consumption/Nutrition/Food Safety,

    Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining

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    This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler, MFPL-Department of Medical Biochemistry, Medical University of Vienna, Max F. Perutz Laboratories, Campus Vienna Biocenter, Vienna, Austria and Ernst Thuer, Centre for Genomic Regulation, Barcelona, Spain, for advice on statistical approaches. Neil Gow acknowledges the support of the Wellcome Trust and the MRC Centre for Medical MycologyPeer reviewedPublisher PD

    Macrophage Migration Is Impaired within Candida albicans Biofilms

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    Acknowledgments: We thank the Microscopy and Histology Core Facility at the University of Aberdeen. This work was funded by NHS Grampian Endowments (grant RG10191); the Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (grant 097377); the Wellcome Trust Investigator award (grants 101873, 086827, 075470, & 200208) and the Medical Research Council Centre for Medical Mycology (grant MR/N006364/1).Peer reviewedPublisher PD

    Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies

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    Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D. studentships for L.A.W. and K.K.L. We also acknowledge research grants from the Wellcome Trust (080088, 086827, 075470, 099215, and 097377) and the British Society for Antimicrobial Chemotherapy.Peer reviewedPublisher PD
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