Search for the Higgs Boson H20H_2^0 at LHC in 3-3-1 Model

We present an analysis of production and signature of neutral Higgs boson ($H_{2}^{0}$) on the version of the 3-3-1 model containing heavy leptons at the Large Hadron Collider. We studied the possibility to identify it using the respective branching ratios. Cross section are given for the collider energy, $\sqrt{s} =$ 14 TeV. Event rates and significances are discussed for two possible values of integrated luminosity, 300 fb$^{-1}$ and 3000 fb$^{-1}$.Comment: 17 pages 7 figures. arXiv admin note: substantial text overlap with arXiv:1205.404

INFLUENCE OF BIOLOGICAL SEX ON SOCIAL BEHAVIOR, INDIVIDUAL RECOGNTION, AND NON-ASSOCIATIVE LEARNING IN THE ADULT GRAY SHORT-TAILED OPOSSUM (MONODELPHIS DOMESTICA)

Social behavior is critical for relationship formation and is influenced by myriad environmental and individual factors. Basic and preclinical research typically relies on rodent models to identify the mechanisms that underlie behavior; however, it is important to use non-rodent models as well. A major objective of the present study was to test the hypothesis that biological sex and social experience modulate the expression of social behavior in the adult gray short-tailed opossum (Monodelphis domestica), a non-traditional model. We also investigated the non-associative learning abilities of these animals. Following a period of social isolation, animals of both sexes were paired with a non-familiar, same-sex partner for 10 minutes on three different occasions, with 24-hour inter-trial intervals. We are the first research group to find significant sex differences in submissive and nonsocial behaviors in Monodelphis. Females displayed significantly higher durations of nonsocial behavior that increased over trials. Males were more aggressive; their latencies to the first attack and submissive behavior decreased over trials whereas these latencies increased for females; males’ duration of submissive behavior increased over trials whereas it decreased for females. A different group of subjects habituated in response to repeated presentations to neutral odors and dishabituated in response to novel odors. In addition, both males and females demonstrated the ability to form social memories in a standard individual (social) recognition test. Our results contribute to the characterization of this marsupial species, an important first step in developing it as a model of complex social behaviors

10 kg scaled-up preparation of Al/Fe-pillared clay CWPO catalysts from concentrated precursors

In this work, the significant intensification of a bentonite pillaring process was achieved by using a novel methodological approach, leading to an intercalating Al/Fe mixed oligomeric precursor, around 100 times more concentrated than usually reported. In addition, the intercalating step was achieved directly on the clay with no previous swelling of the mineral being required; this allowed the successful scaled-up preparation of the Al/Fe-PILC, by a factor of one thousand, from the lab (10 g) to the pilot scale (10 kg). Intercalating solutions prepared under either oncentrated (13 cm3) or diluted (widely reported, 2.0 dm3) conditions for lab-scale preparations were both translucent, displaying similar final pH values (close to 4.0) typical of highly oligomerized Al-pillaring solutions. The clay modified from concentrated precursors at the 10 g scale reached a high basal spacing (18.3 Å) and specific surface area (198 m2 g−1 ) with very comparable fractions of Fe forming truly mixed Al/Fe pillars in comparison to a reference material (H2-TPR analyses). This promoted high performance in the catalytic wet peroxide oxidation of phenol in aqueous solution as a toxic model organic molecule at very mild temperature (25.0 °C ± 1.0 °C) and pressure (76 kPa), exhibiting the highest catalytic efficiency as a function of both parameters (full conversion of phenol together with 45.2% of TOC mineralization) with low iron leaching using a very low catalyst concentration (0.25 g dm−3). Particle size refining of the starting clay, the speed of stirring and conditions for the final washing of the interlayered precursor are the main factors influencing successful pillaring at scales higher than 1.0 kg

Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer's disease

Previous studies have failed to reach consensus on insulin levels in cerebrospinal fluid of Alzheimer's disease (AD) patients and on its relation to pathological features. We performed a new analysis in patients at different stages of AD, and investigated the relationship of insulin levels with biochemical disease markers and with cognitive score. We included 99 patients from our Memory Clinic (Karolinska University Hospital, Sweden), including: 27 patients with mild AD, 13 that progressed from mild cognitive impairment (MCI) to AD in two years time, 26 with MCI stable after two years, and 33 with subjective cognitive impairment. Insulin was significantly decreased in the cerebrospinal fluid of both women and men with mild AD. Insulin deficits were seen in women belonging to both MCI groups, suggesting that this occurs earlier than in men. Insulin was positively associated with amyloid-β 1-42 (Aβ1-42) levels and cognitive score. Furthermore, total-tau/(Aβ1-42*insulin) ratio showed strikingly better sensitivity and specificity than the total-tau/Aβ1-42 ratio for early AD diagnosis in women

Type 2 diabetes mellitus and antibiotic-resistant infections: A Systematic Review and meta-analysis

Background: Type 2 diabetes mellitus (T2DM) has been associated with infectious diseases; however, whether T2DM is associated with bacterial-resistant infections has not been thoroughly studied. We ascertained whether people with T2DM were more likely to experience resistant infections in comparison to T2DM-free individuals. Methods: Systematic review and random-effects meta-analysis. The search was conducted in Medline, Embase, and Global Health. We selected observational studies in which the outcome was resistant infections (any site), and the exposure was T2DM. We studied adult subjects who could have been selected from population-or hospital-based studies. I-squared was the metric of heterogeneity. We used the Newcastle-Ottawa risk of bias scale. Results: The search retrieved 3,370 reports, 97 were studied in detail and 61 (449,247 subjects) were selected. Studies were mostly cross-sectional or case-control; several infection sites were studied, but mostly urinary tract and respiratory infections. The random-effects meta-analysis revealed that people with T2DM were two-fold more likely to have urinary tract (OR= 2.42; 95% CI: 1.83-3.20; I-squared 19.1%) or respiratory (OR= 2.35; 95% CI: 1.49-3.69; I-squared 58.1%) resistant infections. Although evidence for other infection sites was heterogeneous, they consistently suggested that T2DM was 66associated with resistant infections. Conclusions: Compelling evidence suggests that people with T2DM are more likely to experience antibiotic-resistant urinary tract and respiratory infections. The evidence for other infection sites was less conclusive but pointed to the same overall conclusion. These results could guide empirical treatment for patients with T2DM and infections

WadD, a New Brucella Lipopolysaccharide Core Glycosyltransferase Identified by Genomic Search and Phenotypic Characterization

Brucellosis, an infectious disease caused by Brucella, is one of the most extended bacterial zoonosis in the world and an important cause of economic losses and human suffering. The lipopolysaccharide (LPS) of Brucella plays a major role in virulence as it impairs normal recognition by the innate immune system and delays the immune response. The LPS core is a branched structure involved in resistance to complement and polycationic peptides, and mutants in glycosyltransferases required for the synthesis of the lateral branch not linked to the O-polysaccharide (O-PS) are attenuated and have been proposed as vaccine candidates. For this reason, the complete understanding of the genes involved in the synthesis of this LPS section is of particular interest. The chemical structure of the Brucella LPS core suggests that, in addition to the already identified WadB and WadC glycosyltransferases, others could be implicated in the synthesis of this lateral branch. To clarify this point, we identified and constructed mutants in 11 ORFs encoding putative glycosyltransferases in B. abortus. Four of these ORFs, regulated by the virulence regulator MucR (involved in LPS synthesis) or the ByrR/ByrS system (implicated in the synthesis of surface components), were not required for the synthesis of a complete LPS neither for virulence or interaction with polycationic peptides and/or complement. Among the other seven ORFs, six seemed not to be required for the synthesis of the core LPS since the corresponding mutants kept the O-PS and reacted as the wild type with polyclonal sera. Interestingly, mutant in ORF BAB1_0953 (renamed wadD) lost reactivity against antibodies that recognize the core section while kept the O-PS. This suggests that WadD is a new glycosyltransferase adding one or more sugars to the core lateral branch. WadD mutants were more sensitive than the parental strain to components of the innate immune system and played a role in chronic stages of infection. These results corroborate and extend previous work indicating that the Brucella LPS core is a branched structure that constitutes a steric impairment preventing the elements of the innate immune system to fight against Brucella

Ocular Exposure to Particulate Matter and Development of Pterygium: A Case-Control Study

Background: Formation of pterygium has been mainly attributed to exposure to the ultraviolet (UV) radiation. Other factors such as dry weather, wind exposure and microtrauma with dust particles, have been linked to development of pterygium. Objective: To determine the association between ocular exposure to particulate matter and development of pterygium. Methods: This case-control study was conducted in a company dedicated to the production and marketing of toilets. We included a total of 90 cases identified in November 2013 and 184 controls. The diagnosis of pterygium was based on clinical examination. Variables studied included age and job tenure of the participants. Logistic regression analysis was used to assess the effect of exposure on developing pterygium. Results: All study participants were male. The mean age of the cases and controls was 39.9 (SD 9.5) and 37.8 (SD 7.3) years, respectively. 115 (42%) of the participants had a job tenure of 5–8 years. The percentages of cases and controls exposed to particulate matter were 31.1% (n=28) and 30.4% (n=56), respectively (OR 1.08, 95% CI 0.61 to 1.91). Conclusion: We could not observe any association between ocular exposure to particulate matter and development of pterygium

Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass

Context: Plasma YKL-40 is elevated in patients with type 2 diabetes. The potential role of visceral adipose tissue (VAT) as a significant source of YKL-40 is unknown. Objective: In the study circulating and expression levels of YKL-40 were examined in VAT analyzing the contribution of adipocytes and stromovascular fraction cells (SVFCs).Wealso explored YKL-40’s implication in insulin resistance and inflammation and the effect of weight loss on plasma YKL-40 concentrations. PatientsandMethods: Samples obtained from 53 subjects were used in the study.Geneandprotein expression levels of YKL-40 were analyzed in VAT as well as in both adipocytes and SVFCs. In addition, circulating YKL-40 concentrations were measured before and after weight loss achieved either by Roux-en-Y gastric bypass (n 26) or after a conventional dietetic program (n 20). Results: Circulating concentrations and VAT expression of YKL-40 were increased in obese patients with type 2 diabetes (P 0.01) as well as associated with variables of insulin resistance and inflammation. No differences in YKL-40 expression levels between adipocytes and SVFCs were detected. Monocyte chemoattractant protein-1 and homeostasis model assessment emerged (P 0.01) as independent factors predicting circulating YKL-40. Elevated levels of YKL-40 in obese patients decreased after weight loss following a conventional hypocaloric diet (P 0.05) but not via a surgery-induced negative energy balance mediated by the Roux-en-Y gastric bypass. Conclusions: The association of increased YKL-40 mRNA and protein levels in VAT with its circulating concentrations indicates an important contribution of VAT in YKL-40 regulation. Furthermore, our data suggest a relevant role of glucose metabolism and inflammation on YKL-40 regulation