11 research outputs found
Population Immunity against Serotype-2 Poliomyelitis Leading up to the Global Withdrawal of the Oral Poliovirus Vaccine: Spatio-temporal Modelling of Surveillance Data.
BACKGROUND: Global withdrawal of serotype-2 oral poliovirus vaccine (OPV2) took place in April 2016. This marked a milestone in global polio eradication and was a public health intervention of unprecedented scale, affecting 155 countries. Achieving high levels of serotype-2 population immunity before OPV2 withdrawal was critical to avoid subsequent outbreaks of serotype-2 vaccine-derived polioviruses (VDPV2s). METHODS AND FINDINGS: In August 2015, we estimated vaccine-induced population immunity against serotype-2 poliomyelitis for 1 January 2004-30 June 2015 and produced forecasts for April 2016 by district in Nigeria and Pakistan. Population immunity was estimated from the vaccination histories of children 70% population immunity among children <36 mo old. Districts with lower immunity were clustered in northeastern Nigeria and northwestern Pakistan. The accuracy of immunity estimates was limited by the small numbers of non-polio AFP cases in some districts, which was reflected by large uncertainty intervals. Forecasted improvements in immunity for April 2016 were robust to the uncertainty in estimates of baseline immunity (January-June 2015), vaccine coverage, and vaccine efficacy. CONCLUSIONS: Immunity against serotype-2 poliomyelitis was forecasted to improve in April 2016 compared to the first half of 2015 in Nigeria and Pakistan. These analyses informed the endorsement of OPV2 withdrawal in April 2016 by the WHO Strategic Advisory Group of Experts on Immunization
Benchmarking health system performance across states in Nigeria: a systematic analysis of levels and trends in key maternal and child health interventions and outcomes, 2000–2013
Association of Volunteer Communication Mobilizers’ Polio-Related Knowledge and Job-Related Characteristics With Health Message Delivery Performance in Kano District of Nigeria
Discovery of Structurally Diverse Small-Molecule Compounds with Broad Antiviral Activity against Enteroviruses
Spatio-temporal correlation between serotype-2 population immunity and the occurrence of cVDPV2 cases.
<p>Country estimates of serotype-2 population immunity and monthly number of cases of cVDPV2 in (A) Nigeria and (B) Pakistan. Proportion of districts (with 95% confidence intervals) reporting at least one cVDPV2 case within a 6-mo period among all districts/6-mo periods by intervals of 10% of estimated serotype-2 population immunity for (C) Nigeria and (D) Pakistan.</p
Estimated serotype-2 population immunity in January–June 2015 and projected serotype-2 population immunity in April 2016 in Nigeria and Pakistan.
<p>Estimated serotype-2 population immunity in January–June 2015 in (A) Nigeria and (C) Pakistan. Projected serotype-2 population immunity at the moment of OPV2 withdrawal (April 2016) in (B) Nigeria and (D) Pakistan. The inserts of (C) and (D) show the administrative areas of Karachi. The publication of this map does not imply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.</p