Classical, semiclassical, and quantum investigations of the 4-sphere scattering system

A genuinely three-dimensional system, viz. the hyperbolic 4-sphere scattering system, is investigated with classical, semiclassical, and quantum mechanical methods at various center-to-center separations of the spheres. The efficiency and scaling properties of the computations are discussed by comparisons to the two-dimensional 3-disk system. While in systems with few degrees of freedom modern quantum calculations are, in general, numerically more efficient than semiclassical methods, this situation can be reversed with increasing dimension of the problem. For the 4-sphere system with large separations between the spheres, we demonstrate the superiority of semiclassical versus quantum calculations, i.e., semiclassical resonances can easily be obtained even in energy regions which are unattainable with the currently available quantum techniques. The 4-sphere system with touching spheres is a challenging problem for both quantum and semiclassical techniques. Here, semiclassical resonances are obtained via harmonic inversion of a cross-correlated periodic orbit signal.Comment: 12 pages, 5 figures, submitted to Phys. Rev.

The role of serum podocalyxin levels in recurrent pregnancy loss

Objective: To measure serum levels of podocalyxin (PODXL) in recurrent miscarriages as a marker of vascular endothelial dysfunction. Study design: In this case-control study, women who were hospitalized for singleton first-trimester pregnancy terminations due to missed abortion, anembryonic pregnancy, and inevitable abortion were included. There were 24 patients who were admitted for the first pregnancy termination, 39 patients who were admitted for recurrent pregnancy loss (RPL), and 25 fetal cardiac activity positive patients as the control group. Demographic features, medical and obstetric histories were recorded. The measurements of serum PODXL were done by a human enzyme-linked immunosorbent assay kit. Results: Serum PODXL levels were found to be significantly higher in the RPL group than the control group and the first time miscarriage group (13.82 [10.09 113.54] vs. 11.78 [9.25 48.80], p = 0.016 and 13.82 [10.09–113.54] vs. 11.99 [8.20–20.47], p = 0.003; respectively). Serum PODXL levels were not statistically significantly different between the first miscarriage and the control group (p = 0.62). There were positive correlation between serum PODXL levels and the number of gravida and the number of miscarriages (r = 0.217, p = 0.042, and r = 0.291, p = 0.006; respectively). Conclusion: Recurrent miscarriage patients had higher serum levels of PODXL than both normal pregnancies and first-time miscarriages. Our results suggest that maternal endothelial dysfunction might have a role in recurrent pregnancy losses

Superiority of semiclassical over quantum mechanical calculations for a three-dimensional system

In systems with few degrees of freedom modern quantum calculations are, in general, numerically more efficient than semiclassical methods. However, this situation can be reversed with increasing dimension of the problem. For a three-dimensional system, viz. the hyperbolic four-sphere scattering system, we demonstrate the superiority of semiclassical versus quantum calculations. Semiclassical resonances can easily be obtained even in energy regions which are unattainable with the currently available quantum techniques.Comment: 10 pages, 1 figure, submitted to Phys. Lett.

The Effects of Vitamin D Receptor Silencing on the Expression of LVSCC-A1C and LVSCC-A1D and the Release of NGF in Cortical Neurons

Recent studies have suggested that vitamin D can act on cells in the nervous system. Associations between polymorphisms in the vitamin D receptor (VDR), age-dependent cognitive decline, and insufficient serum 25 hydroxyvitamin D(3) levels in Alzheimer's patients and elderly people with cognitive decline have been reported. We have previously shown that amyloid β (Aβ) treatment eliminates VDR protein in cortical neurons. These results suggest a potential role for vitamin D and vitamin D-mediated mechanisms in Alzheimer's disease (AD) and neurodegeneration. Vitamin D has been shown to down-regulate the L-type voltage-sensitive calcium channels, LVSCC-A1C and LVSCC-A1D, and up-regulate nerve growth factor (NGF). However, expression of these proteins when VDR is repressed is unknown. The aim of this study is to investigate LVSCC-A1C, LVSCC-A1D expression levels and NGF release in VDR-silenced primary cortical neurons prepared from Sprague-Dawley rat embryos.qRT-PCR and western blots were performed to determine VDR, LVSCC-A1C and -A1D expression levels. NGF and cytotoxicity levels were determined by ELISA. Apoptosis was determined by TUNEL. Our findings illustrate that LVSCC-A1C mRNA and protein levels increased rapidly in cortical neurons when VDR is down-regulated, whereas, LVSCC-A1D mRNA and protein levels did not change and NGF release decreased in response to VDR down-regulation. Although vitamin D regulates LVSCC-A1C through VDR, it may not regulate LVSCC-A1D through VDR.Our results indicate that suppression of VDR disrupts LVSCC-A1C and NGF production. In addition, when VDR is suppressed, neurons could be vulnerable to aging and neurodegeneration, and when combined with Aβ toxicity, it is possible to explain some of the events that occur during neurodegeneration

Akciğer sarkoidozunda radyolojik bulgular, solunum fonksiyon testleri ve bronkoalveoler lavaj bulguları arasındaki ilişki

Chest radiographies, computed tomography (CT), pulmonary function tests (PFT) and bronchoalveolar lavage (BAL) findings of 77 sarcoidosis cases were studied retrospectively according to stages. According to chest radiographies in 3 cases (3.9%) right hilar, in 23 cases (29.9%) bilateral hilar, in 2 cases (2.6%) only right paratracheal lymph node and in 38 cases (49.4%) both bilateral hilar and right paratracheal involvement was seen. in parenchymal examination, acinar shadows in 13 cases (16.9%), reticulonodular shadows in 14 cases (18.2), in 13 cases (16.9%) reticular and in 2 cases (2.6%) nodular images were noted. Thorax CT was performed from 73 cases. in 66 cases (91.7%) right hilar, in 62 cases (86.1%) left hilar, in 33 cases (45.8%) right paratracheal, in 33 cases (45.8%) bilateral paratracheal, in 50 cases (69.4%) subcarinal in 35 cases (48.6%) carinal, in 43 cases (59.7%) prevascular, and in 27 cases (37.5%) azygoesophagial lymph node involuement was detected. Parenchymal examination revealed reticulonodular involvement in 13 cases (18.1%), acinar shadows in 11 cases (15.3%), parenchymal nodules in 24 cases (33.3%) and peribronchial and interlobular septal thickness in 10 cases (13.9%). Decrease of BAL lymphocyte rate was noted, when the parenchymal involvement increases (p;lt; 0.01). in PFTs, significant decrease in FEV1 and FVC according to stages was found as expected (p;lt; 0.01). Gallium 67 scans was taken from 26 cases and in 12 cases parenchymal and 21 cases mediastinal involvement was noted. the correlation between parenchymal involvement in gallium 67 scans and CT was found to be significant (p;lt; 0.05).Ellidört (%70.1) kadın, 23 (%29.9) erkek olmak üzere toplam 77 sarkoidoz olgusunun direkt akciğer grafileri, bilgisayarlı tomografileri (BT) ve solunum fonksiyon testleri (SFT) retrospeküf olarak evrelere göre değerlendirilmiş, aralarında korelasyon araştırılmıştır. Akciğer grafisine göre 3 (%3.9) olguda sağ hiler, 23 (%29.9) olguda bilateral hiler, 2 (%2.6) olguda sadece sağ paratrakeal lenf bezi tutulumu, 38 (%49.4) olguda bilateral hiler + sağ paratrakeal tutulum izlenmiştir. Parankimde ise; 13 (%16.9) asiner gölgeler, 14 (%18.2) retikülonodüler gölgeler, 13 (%16.9) retiküler, 2 (%2.6) nodüler görünüm izlenmiştir. Yetmişüç olguya toraks BT çekilmiş, mediasten lenf bezi ve parankim tutulumu değerlendirilmiştir. Altmışaltı (%91.7) olguda sağ hilus, 62 (%86.1) olguda sol hilus, 33 (%45.8) olguda sağ paratrakeal, 33 (%45.8) olguda bilateral paratrakeal, 50 (%69.4) olguda subkarinal, 35 (%48.6) olguda karinal, 43 (%59.7) olguda prevasküler, 27 (%37.5) olguda azigoözefageal lenf bezleri tutulumu saptanmıştır. Parankim değerlendirildiğinde; 13 (%18.1) retikülonodüler, 11 (%15.3) asiner gölgeler, 24 (%33.3) parankimal nodül, 10 (%13.9) peribronşiyal ve interlober septal kalınlaşma izlenmiş, parankim tutulumu arttıkça bronkoalveoler lavaj (BAL) lenfosit oranının azaldığı gözlenmiştir (p 0.01). Otuzyedi olguya SFT yapılmış, FEV1, FVC değerlerinde evrelere göre azalma anlamlı bulunmuş, DLCO'da evreler arası azalma istatistiksel anlamlılık göstermezken evre 1 ile evre 3 arasındaki azalma anlamlı bulunmuştur (p 0.01). Yirmialtı olguya galyum sintigrafisi çekilmiş, 12 olguda parankim, 21 olguda mediasten tutulumu gözlenmiştir. Galyum sintigrafisinde parankim tutulumu pozitifliği ile BT parankim tutulum yaygınlığı arasındaki ilişki istatistiksel olarak anlamlı bulunmuştur (p 0.05)

Strateji odaklı organizasyonel performans yönetim sistemi kapsamında entellektüel sermaye performansının ölçümü

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır.Strateji Odaklı Organizasyonel Performans Yönetim Sistemi Kapsamında Entelektüel Sermaye Performansının Ölçümü isimli bu çalışmada son dönemde literatürde yer almaya başlayan entelektüel sermaye konusu ele alınarak araştırılmıştır. Bilginin işletme faaliyetlerinde öneminin giderek artması, bilgiyi işletmenin önemli varlıklarından biri haline getirmiştir. Bilgiye dayalı varlıkların işletmelere uzun dönemde rekabet üstünlüğü yaratacak varlıklar olması onun stratejik bakış açısıyla değerlendirilmesini gerektirmektedir. Bilgi varlıklarının geleneksel muhasebe sistemlerinde gözükmemesi, işletmenin piyasa değerinin büyümesine ve işletme defter değeri ile piyasa değeri arasındaki farkın açılmasına neden olmuştur. Bu fark genel olarak entelektüel sermaye olarak nitelendirilmektedir. Entelektüel sermayenin özellikle bilgi yoğun sektörlerde önemli değerlere ulaşması entelektüel sermayeyi yönetmeyi, iyi bir yönetim için de entelektüel sermayeyi ölçmeyi zorunlu hale getirmiştir. Çalışmamız entelektüel sermaye performansının işletme stratejileri doğrultusunda ölçülmesi temeline dayanmaktadır. Bu kapsamda çalışmamızda öncelikle performans yönetim sistemi içinde entelektüel sermayenin performansının yeri tanımlanmış, entelektüel sermaye kavramına açıklık getirecek tanımlamalara ve sınıflamalara yer verilmiştir.Entelektüel sermayeyi ölçme, değerlendirme ve raporlama konusunda gerek uygulayıcılar gerekse akademisyenler tarafından geliştirilen modeller sınıflanarak tanıtılmıştır. Son olarak ise performans ölçümünde uyguladıkları metot açısından mevcut modellerin yetersiz kaldığı düşünülen konulardaki boşluğu gidermek ve henüz yeni olan bu konudaki literatüre katkı sağlamak amacıyla entelektüel sermaye performansını değerleyecek iki boyutlu hedef puan metodu adını verdiğimiz bir metot geliştirilmiştir.THE MEASUREMENT OF INTELLECTUAL CAPITAL PERFORMANCE USING THE ORGANIZATIONAL PERFORMANCE MANAGEMENT SYSTEM, FOCUSING ON STRATEGY KEYWORDS: Strategy, Performance,Measurement,Intellectual Capital In recent years the increasing importance of intellectual capital has demanded management and measurement of intellectual capital.New methods have been developed to measure intellectual capital. Our target is to develop a new method,using existing studies and complying to the organizational strategy. With the new method,the components of intellectual capital will evaluate the difference between book value and market value of the business. As a result of the new method,the development of a business could be measured more accurately.The effect of the market value of the business,the performance of the intellectual performance according to targets and a prevention plan could all be monitored.Thus making goals easier to achieve and the business more successful