An unusual case of an intramuscular lipoma of the biceps brachii

Lipomas are common benign neoplasms consisting of mature fatty tissue. They are usually of roundish or ovoid shape and are situated in a single anatomical region. They most frequently occur on the back and in the extremities. Most lipomas are subcutaneous and require no imaging evaluation. When deep, large and unusual in location, MRI can identify and localise these tumours and is the best exploration to differentiate lipoma and lipo-sarcoma. We describe a case of a patient with an intramuscular lipoma of the biceps brachii.Key words: Intramuscular, lipoma, biceps brachi

Faculty perception of engineering student cheating and effective measures to curb it

© 2019 IEEE. Engineering faculty were surveyed on issues related to academic dishonesty by students affiliated with their college at an American university located in the United Arab Emirates. The survey addressed perceived frequency of plagiarism, unauthorized collaboration, cheating, copyright violations and complicity in academic integrity. As expected, the majority of the faculty think that dishonesty is more common in-of-class work compared to proctored exams. They think that applying tougher penalties and using more proctors are the most effective methods in decreasing academic dishonesty. The authors believe that it would be helpful if faculty members follow the university\u27s policy on cheating rather than make up their own rules in order to have consistent approach in dealing with academic dishonesty violations across the whole university. Ideally, the best way to combat dishonest acts at an institution is by educating students through seminars and workshops about the virtues of academic integrity and the benefits it brings to society. But until our campuses become free of dishonest behavior by students, some practical measures should be undertaken by the faculty to safeguard the institution against unethical behavior by students. For example, faculty members are recommended to either make their own assignments or modify the end-of-chapter problems from textbooks because students may have access to solution manuals. They are encouraged to give different homework problems and projects from one semester to another since students may have access to graded past work. While test banks provided to faculty by publishers may be used as a guide when creating exams, problems from such sources should not be put verbatim on exams by faculty because they are often available for purchase by students on the internet. Furthermore, the weight of-of-class assignments relative to the total course grade should be a small fraction of the total weight to discourage students from cheating on homework. Wireless signal jamming devices can combat some acts of e-cheating that utilizes the internet by disrupting communication between a smart phone and the cell-phone base station

Camel Milk Modulates the Expression of Aryl Hydrocarbon Receptor-Regulated Genes, Cyp1a1, Nqo1, and Gsta1, in Murine hepatoma Hepa 1c1c7 Cells

There is a traditional belief in the Middle East that camel milk may aid in prevention and treatment of numerous cases of cancer yet, the exact mechanism was not investigated. Therefore, we examined the ability of camel milk to modulate the expression of a well-known cancer-activating gene, Cytochrome P450 1a1 (Cyp1a1), and cancer-protective genes, NAD(P)H:quinone oxidoreductase 1 (Nqo1) and glutathione S-transferase a1 (Gsta1), in murine hepatoma Hepa 1c1c7 cell line. Our results showed that camel milk significantly inhibited the induction of Cyp1a1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent Cyp1a1 inducer and known carcinogenic chemical, at mRNA, protein, and activity levels in a concentration-dependent manner. In addition, camel milk significantly decreased the xenobiotic responsive element (XRE)-dependent luciferase activity, suggesting a transcriptional mechanism is involved. Furthermore, this inhibitory effect of camel milk was associated with a proportional increase in heme oxygenase 1. On the other hand, camel milk significantly induced Nqo1 and Gsta1 mRNA expression level in a concentration-dependent fashion. The RNA synthesis inhibitor, actinomycin D, completely blocked the induction of Nqo1 mRNA by camel milk suggesting the requirement of de novo RNA synthesis through a transcriptional mechanism. In conclusion, camel milk modulates the expression of Cyp1a1, Nqo1, and Gsta1 at the transcriptional and posttranscriptional levels

N′-(Adamantan-2-yl­idene)thio­phene-2-carbohydrazide

In the title mol­ecule, C15H18N2OS, a small twist is noted, with the dihedral angle between the central carbohydrazone residue (r.m.s. deviation = 0.029 Å) and the thio­phene ring being 12.47 (10)°. The syn arrangement of the amide H and carbonyl O atoms allows for the formation of centrosymmetric dimers via N—H⋯O hydrogen bonds. These are linked in the three-dimensional structure by C—H⋯π inter­actions. The thio­phene ring is disordered over two co-planar orientations, the major component having a site-occupancy factor of 0.833 (2)

Synthesis, biological evaluation and Structure Activity Relationships (SARs) study of 8-(substituted)aryloxycaffeine

AbstractA series of 8-(substituted)aryloxycaffeine were prepared from 8-bromocaffeine and (substituted)phenols by modified Ullmann reaction. In vitro antibacterial activity, inhibitory activity on topoisomerase II and pharmacological activities were evaluated for the synthesized 8-(substituted)aryloxycaffeine. Among the synthesized compounds, 8-(5-chloropyridin-3-yloxy)caffeine (3k) showed strong inhibitory activity (MIC=15.6μg/mL) against the tested gram negative (−) bacteria Salmonella enteritidis. 8-(quinolin-8-yloxy)caffeine (3g) showed the strongest inhibitory activity against topoisomerase II. And the compounds 8-(6-methylpyridin-2-yloxy)caffeine (3j) and 8-(3-chloro-6-(trifluoromethyl)pyridin-2-yloxy)caffeine (3m) showed analgesic effect without the central nervous system stimulation

3-(Adamantan-1-yl)-4-ethyl-1H-1,2,4-triazole-5(4H)-thione

In the title compound, C14H21N3S, the 1,2,4-triazole ring is nearly planar, with a maximum deviation of 0.003 (4) Å. In the crystal, mol­ecules are linked into inversion dimers by pairs of N—H⋯S hydrogen bonds

2-(Adamantan-1-yl)-5-(4-nitro­phen­yl)-1,3,4-oxadiazole

The title mol­ecule, C18H19N3O3, lies on a mirror plane that bis­ects the adamantyl group. In the crystal, C—H⋯O and C—H⋯N inter­actions lead to supra­molecular chains along [100]. These assemble into layers in the ab plane via π–π inter­actions [centroid–centroid distance = 3.6548 (7) Å] between the oxadiazole and benzene rings

1-(5-Bromo-4-phenyl-1,3-thia­zol-2-yl)pyrrolidin-2-one

The asymmetric unit of the title compound, C13H11BrN2OS, consists of two crystallographically independent mol­ecules (A and B). In each mol­ecule, the pyrrolidine ring adopts an envelope conformation with a methyl­ene C atom as the flap atom. In mol­ecule A, the central thia­zole ring makes a dihedral angle of 36.69 (11)° with the adjacent phenyl ring, whereas the corresponding angle is 36.85 (12)° in mol­ecule B. The pyrrolidine ring is slightly twisted from the thia­zole ring, with C—N—C—N torsion angles of 4.8 (3) and 3.0 (4)° in mol­ecules A and B, respectively. In the crystal, C—H⋯π and π–π [centroid-to-centroid distance = 3.7539 (14) Å] inter­actions are observed. The crystal studied was a pseudo-merohedral twin with twin law (-100 0-10 101) and a refined component ratio of 0.7188 (5):0.2812 (5)

Isolated radial volar dislocation of the fifth carpometacarpal joint :A rare injury

Isolated palmar dislocation of the fifth carpometacarpal joint is an uncommon injury and classified as radio-palmar or ulno-palmar according to the direction of displacement of the fifth metacarpal base . This very rare injury is often  difficult to recognize. A careful neurologic assessment of the patient is a  necessity, as well as obtaining proper radiographs of the hand. The purpose of this report is to present a patient with a pure isolated volar dislocation of the fifth carpometacarpal joint that was satisfactorily treated with closed  reduction and casting. A review of the literature is presente