59 research outputs found
Moving Targets, Long-Lived Infrastructure, and Increasing Needs for Integration and Adaptation in Water Management: An Illustration from Switzerland
Structure of an RNA polymerase II–RNA inhibitor complex elucidates transcription regulation by noncoding RNAs.
The noncoding RNA B2 and the RNA aptamer FC bind RNA polymerase (Pol) II and inhibit messenger RNA transcription initiation, but not elongation. We report the crystal structure of FC*, the central part of FC RNA, bound to Pol II. FC* RNA forms a double stem-loop structure in the Pol II active center cleft. B2 RNA may bind similarly, as it competes with FC* RNA for Pol II interaction. Both RNA inhibitors apparently prevent the downstream DNA duplex and the template single strand from entering the cleft after DNA melting and thus interfere with open-complex formation. Elongation is not inhibited, as nucleic acids prebound in the cleft would exclude the RNA inhibitors. The structure also indicates that A-form RNA could interact with Pol II similarly to a B-form DNA promoter, as suggested for the bacterial transcription inhibitor 6S RNA
The impact of potential influencing factors on the recovery rate of bank loans of small and medium-sized companies: A survey of bank practicioners
Facetten der Zeitdimension — Ansatzpunkte für die Entwicklung eines Zeitmanagementkonzepts
Dealing with Natural Hazard Risks in Switzerland – The Influence of Hazard Mapping on Risk-Based Decision Making
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