Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro

Leishmaniasis is a disease that is a significant problem for people, especially in tropical regions of the world. Current drug therapies to treat the disease are expensive, not very effective, and/or of significant side effects. A series of alkyl bisphosphonate compounds and one amino bisphosphonate compound, as well as alendronate and zoledronate, were tested as potential agents against Leishmania tarentolae. Also, two polyoxometalates (POMs) with nitrogen-containing bisphosphonate ligands, vanadium/alendronate (V5(Ale)2) and vanadium/zoledronate (V3(Zol)3), were tested against L. tarentolae and compared to the results of the alendronate and zoledronate ligands alone. Of the compounds evaluated in this study, the V5(Ale)2 and V3(Zol)3 complexes were most effective in inhibiting the growth of L. tarentolae. The V5(Ale)2 complex had a larger impact on cell growth than either alendronate or orthovanadate alone, whereas zoledronate itself has a significant effect on cell growth, which may contribute to the activity of the V3(Zol)3 complex

Anderson-type Polyoxometalates Functionalized by a New Class of Organic Photochromic Molecule

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Gold/Polyoxometalate core/shell nanoparticles for combined chemotherapy/photothermal cancer therapy

International audienc

Synthesis and Antibacterial Properties of a New Generation of Hybrid Polyoxometalate / Antibiotic / Gold/Nanoparticle Nanocomposites

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Mo-V-Mo-VI mixed valence polyoxometalates for facile synthesis of stabilized metal nanoparticles: Electrocatalytic oxidation of alcohols

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Heterogenisation of polyoxometalates and other metal-based complexes in metal–organic frameworks: from synthesis to characterisation and applications in catalysis

International audienceThese last years have seen a huge growing interest in the heterogenisation of molecular catalysts since it allows combining the advantages of homogeneous and heterogeneous catalysis. Besides bringing recyclability, the immobilisation of the catalyst may increase its stability while allowing tuning its selectivity. In this respect, Metal-Organic Frameworks (MOFs) attract an evergrowing interest as a platform for their confinement within their pores or channels. In this review, Cat@MOF composites whereby molecular catalysts (Cats) are immobilised in MOFs through non-covalent interactions with their host, are reviewed thoroughly. Polyoxometalates (POMs) and other metal-based complexes as immobilised molecular species are covered. In the first part, the different synthetic methods and analytical tools are described. A critical analysis of the various physico-chemical methods available to characterise the Cat@MOF composites is provided-a particular attention being paid toward their pertinence for the investigation of the content, the position and the stability of the catalyst within the MOF. Besides, focus is made on non-conventional techniques such as Pair Distribution Function (PDF) and a section is dedicated to the contribution of DFT calculations. In the second part, the applications of these materials in the fields of catalysis, including oxidation and reduction reactions, acid-base catalysis, photo-and electrocatalysis are detailed