Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro

Leishmaniasis is a disease that is a significant problem for people, especially in tropical regions of the world. Current drug therapies to treat the disease are expensive, not very effective, and/or of significant side effects. A series of alkyl bisphosphonate compounds and one amino bisphosphonate compound, as well as alendronate and zoledronate, were tested as potential agents against Leishmania tarentolae. Also, two polyoxometalates (POMs) with nitrogen-containing bisphosphonate ligands, vanadium/alendronate (V5(Ale)2) and vanadium/zoledronate (V3(Zol)3), were tested against L. tarentolae and compared to the results of the alendronate and zoledronate ligands alone. Of the compounds evaluated in this study, the V5(Ale)2 and V3(Zol)3 complexes were most effective in inhibiting the growth of L. tarentolae. The V5(Ale)2 complex had a larger impact on cell growth than either alendronate or orthovanadate alone, whereas zoledronate itself has a significant effect on cell growth, which may contribute to the activity of the V3(Zol)3 complex

Building block libraries and structural considerations in the self-assembly of polyoxometalate and polyoxothiometalate systems

Inorganic metal-oxide clusters form a class of compounds that are unique in their topological and electronic versatility and are becoming increasingly more important in a variety of applications. Namely, Polyoxometalates (POMs) have shown an unmatched range of physical properties and the ability to form structures that can bridge several length scales. The formation of these molecular clusters is often ambiguous and is governed by self-assembly processes that limit our ability to rationally design such molecules. However, recent years have shown that by considering new building block principles the design and discovery of novel complex clusters is aiding our understanding of this process. Now with current progress in thiometalate chemistry, specifically polyoxothiometalates (POTM), the field of inorganic molecular clusters has further diversified allowing for the targeted development of molecules with specific functionality. This chapter discusses the main differences between POM and POTM systems and how this affects synthetic methodologies and reactivities. We will illustrate how careful structural considerations can lead to the generation of novel building blocks and further deepen our understanding of complex systems

Anderson-type Polyoxometalates Functionalized by a New Class of Organic Photochromic Molecule

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Photo-excitation from dia- to ferri-magnetism in a Rb-Co-hexacyanoferrate Prussian blue analogue

PACS. 75.50.Xx Molecular magnets - 78.40.Ha Other nonmetallic inorganics - 82.20.Mj Nonequilibrium kinetics,

Gold/Polyoxometalate core/shell nanoparticles for combined chemotherapy/photothermal cancer therapy

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Synthesis and Characterization of Polyoxometalates/Antibiotics/Gold Nanoparticles Hybrid Materials for Antibacterial Applications

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Synthesis and Antibacterial Properties of a New Generation of Hybrid Polyoxometalate / Antibiotic / Gold/Nanoparticle Nanocomposites

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