Using zebrafish (Danio rerio) to study the behavioral impacts of early bisphenol F exposure reveals decreased swim speed, increased distance between fish, and increased freezing behaviors

The widespread use of endocrine disrupting chemicals (EDCs) has been a source of concern because of their various effects on the endocrine system. These effects include metabolic disorders, complications in reproductive health, hormone-related cancers, and neurodevelopmental disorders. Of particular concern is bisphenol A (BPA), a synthetic compound commonly found in consumer products such as water bottles, thermal receipt paper, and epoxy resins used in processed food packaging. Previous studies have shown that BPA can mimic estrogen through a variety of mechanisms and thus elicit an endocrine response. Some manufacturers have responded by removing BPA from their products; however, studies using a replacement compound bisphenol S have reported it to be just as, if not more, dangerous. The use of zebrafish (Danio rerio) larvae as a model organism allows for the effects of bisphenol exposure to be rapidly quantified through a simple behavioral assay. In studies involving bisphenol exposure, the use of zebrafish has demonstrated reproductive, developmental, endocrine, and behavioral effects. The study of bisphenol F, yet another endocrine disruptor that has become a replacement for BPA in consumer products, is highly important to public safety

2014 Local Food Consumption in Vermont

This paper revisits and updates a 2011 study to count local food consumption in Vermont. We find consumption increased to about $188 million in 2014, with increases across most categories

A study of the mechanism of chemical reactivity of nitrogen tetroxide with titanium alloys Quarterly report, 1 Oct. - 31 Dec. 1967

Corrosion test of titanium alloys with nitrogen tetroxid

Reduction of high-speed impulsive noise by blade planform modification of a model helicopter rotor

The reduction of high speed impulsive noise for the UH-1H helicopter was investigated by using an advanced main rotor system. The advanced rotor system had a tapered blade planform compared with the rectangular planform of the standard rotor system. Models of both the advanced main rotor system and the UH-1H standard main rotor system were tested at 1/4 scale in the 4 by 7 Meter Tunnel. In plane acoustic measurements of the high speed impulsive noise demonstrated that the advanced rotor system on the UH-1H helicopter reduced the high speed impulsive noise by up to 20 dB, with a reduction in overall sound pressure level of up to 5 dB

Crystal structure analysis of intermetallic compounds

Study concerns crystal structures and lattice parameters for a number of new intermetallic compounds. Crystal structure data have been collected on equiatomic compounds, formed between an element of the Sc, Ti, V, or Cr group and an element of the Co or Ni group. The data, obtained by conventional methods, are presented in an easily usable tabular form

Concordance of Bing doubles and boundary genus

Cha and Kim proved that if a knot K is not algebraically slice, then no iterated Bing double of K is concordant to the unlink. We prove that if K has nontrivial signature $\sigma$, then the n-iterated Bing double of K is not concordant to any boundary link with boundary surfaces of genus less than $2^{n-1}\sigma$. The same result holds with $\sigma$ replaced by $2\tau$, twice the Ozsvath-Szabo knot concordance invariant.Comment: 13 pages, 7 figure

Movement and habitat use of two aquatic turtles (\u3cem\u3eGraptemys geographic\u3c/em\u3e and \u3cem\u3eTrachemys scripta\u3c/em\u3e) in an urban landscape

Our study focuses on the spatial ecology and seasonal habitat use of two aquatic turtles in order to understand the manner in which upland habitat use by humans shapes the aquatic activity, movement, and habitat selection of these species in an urban setting. We used radiotelemetry to follow 15 female Graptemys geographica (common map turtle) and each of ten male and female Trachemys scripta (red-eared slider) living in a man-made canal within a highly urbanized region of Indianapolis, IN, USA. During the active season (between May and September) of 2002, we located 33 of the 35 individuals a total of 934 times and determined the total range of activity, mean movement, and daily movement for each individuals. We also analyzed turtle locations relative to the upland habitat types (commercial, residential, river, road, woodlot, and open) surrounding the canal and determined that the turtles spent a disproportionate amount of time in woodland and commercial habitats and avoided the road-associated portions of the canal. We also located 21 of the turtles during hibernation (February 2003), and determined that an even greater proportion of individuals hibernated in woodland-bordered portions of the canal. Our results clearly indicate that turtle habitat selection is influenced by human activities; sound conservation and management of turtle populations in urban habitats will require the incorporation of spatial ecology and habitat use data

Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs

Oncolytic viruses are emerging as a potential new way of treating cancers. They are selectively replication-competent viruses that propagate only in actively dividing tumor cells but not in normal cells and, as a result, destroy the tumor cells by consequence of lytic infection. At least six different oncolytic herpes simplex viruses (oHSVs) have undergone clinical trials worldwide to date, and they have demonstrated an excellent safety profile and intimations of efficacy. The first pivotal Phase III trial with an oHSV, talimogene laherparepvec (T-Vec [OncoVex<sup>GM-CSF</sup>]), is almost complete, with extremely positive early results reported. Intuitively, therapeutically beneficial interactions between oHSV and chemotherapeutic and targeted therapeutic drugs would be limited as the virus requires actively dividing cells for maximum replication efficiency and most anticancer agents are cytotoxic or cytostatic. However, combinations of such agents display a range of responses, with antagonistic, additive, or, perhaps most surprisingly, synergistic enhancement of antitumor activity. When synergistic interactions in cancer cell killing are observed, chemotherapy dose reductions that achieve the same overall efficacy may be possible, resulting in a valuable reduction of adverse side effects. Therefore, the combination of an oHSV with “standard-of-care” drugs makes a logical and reasonable approach to improved therapy, and the addition of a targeted oncolytic therapy with “standard-of-care” drugs merits further investigation, both preclinically and in the clinic. Numerous publications report such studies of oncolytic HSV in combination with other drugs, and we review their findings here. Viral interactions with cellular hosts are complex and frequently involve intracellular signaling networks, thus creating diverse opportunities for synergistic or additive combinations with many anticancer drugs. We discuss potential mechanisms that may lead to synergistic interactions

Experimental blade vortex interaction noise characteristics of a utility helicopter at 1/4 scale

Models of both the advanced main rotor system and the standard or "baseline" UH-1 main rotor system were tested at one-quarter scale in the Langley 4- by 7-Meter (V/STOL) Tunnel using the general rotor model system. Tests were conducted over a range of descent angles which bracketed the blade-vortex interaction phenomenon for a range of simulated forward speeds. The tunnel was operated in the open-throat configuration with acoustic treatment to improve the semi-anechoic characteristics of the test chamber. Acoustical data obtained for these two rotor systems operating at similar flight conditions are presented without analysis or discussion

Titanium alloy stress corrosion cracking in presence of dinitrogen tetroxide

Study resulting in a satisfactory stress corrosion cracking test with extremely consistent results produced six new analytical methods. Methods detect and determine differences in the minor constituent composition of different types of dinitrogen tetroxide