Can we use starlings' aversion to eyespots as the basis for a novel 'cognitive bias' task?

Experiments in humans have shown that changes in emotional (affective) state cause adaptive changes in the processing of incoming information, termed "cognitive bias". For instance, the states of anxiety and depression have been shown to be associated with "pessimistic" judgements of ambiguous stimuli intermediate between stimuli associated with positive and negative outcomes. This phenomenon provides a promising method for objectively assessing animal emotional states and has been successfully demonstrated in preliminary studies. However, the experiments yielding these results required extensive training to establish the necessary positive and negative associations. Here we present an experiment using responses to eyespot stimuli that are naturally aversive to many bird species, and require no explicit associative training. We manipulated the state of wild-caught European starlings (Sturnus vulgaris) by playing one of four possible sounds: starling "threat call" (control manipulation), a sparrowhawk call (i.e. predator), starling alarm call or white noise, on the assumption that the latter three sounds would cause anxiety. Immediately following the auditory stimulus, we recorded the birds' behaviour in the presence of each of three visual stimuli: eyespots, ambiguous eyespots or no eyespots. We hypothesised that there would be an interaction between the state of the birds and their response to eyespots, with birds showing enhanced aversion to ambiguous eyespots when anxious. We found evidence that white noise and alarm calls generated anxiety, and that eyespots were aversive. However, there was no interaction between state and response to eyespots. In an attempt to understand our failure to obtain the predicted cognitive bias, we discuss evidence that the aversive nature of eyespots is not attributable to predator mimicry, and is therefore not modulated by anxiety. © 2009 Elsevier B.V. All rights reserved

Novel Properties of Frustrated Low Dimensional Magnets with Pentagonal Symmetry

In the context of magnetism, frustration arises when a group of spins cannot find a configuration that minimizes all of their pairwise interactions simultaneously. We consider the effects of the geometric frustration that arises in a structure having pentagonal loops. Such five-fold loops can be expected to occur naturally in quasicrystals, as seen for example in a number of experimental studies of surfaces of icosahedral alloys. Our model considers classical vector spins placed on vertices of a subtiling of the two dimensional Penrose tiling, and interacting with nearest neighbors via antiferromagnetic bonds. We give a set of recursion relations for this system, which consists of an infinite set of embedded clusters with sizes that increase as a power of the golden mean. The magnetic ground states of this fractal system are studied analytically, and by Monte Carlo simulation.Comment: 7 pages, 7 figures, contribution to ICQ11 (Sapporo, Japan 2010) conference proceeding

High-Quality Shared-Memory Graph Partitioning

Partitioning graphs into blocks of roughly equal size such that few edges run between blocks is a frequently needed operation in processing graphs. Recently, size, variety, and structural complexity of these networks has grown dramatically. Unfortunately, previous approaches to parallel graph partitioning have problems in this context since they often show a negative trade-off between speed and quality. We present an approach to multi-level shared-memory parallel graph partitioning that guarantees balanced solutions, shows high speed-ups for a variety of large graphs and yields very good quality independently of the number of cores used. For example, on 31 cores, our algorithm partitions our largest test instance into 16 blocks cutting less than half the number of edges than our main competitor when both algorithms are given the same amount of time. Important ingredients include parallel label propagation for both coarsening and improvement, parallel initial partitioning, a simple yet effective approach to parallel localized local search, and fast locality preserving hash tables

Multi-step Richardson-Romberg Extrapolation: Remarks on Variance Control and complexity

We propose a multi-step Richardson-Romberg extrapolation method for the computation of expectations $E f(X_{_T})$ of a diffusion $(X_t)_{t\in [0,T]}$ when the weak time discretization error induced by the Euler scheme admits an expansion at an order $R\ge 2$. The complexity of the estimator grows as $R^2$ (instead of $2^R$) and its variance is asymptotically controlled by considering some consistent Brownian increments in the underlying Euler schemes. Some Monte carlo simulations carried with path-dependent options (lookback, barriers) which support the conjecture that their weak time discretization error also admits an expansion (in a different scale). Then an appropriate Richardson-Romberg extrapolation seems to outperform the Euler scheme with Brownian bridge.Comment: 28 pages, \`a para\^itre dans Monte Carlo Methods and Applications Journa

On the mass of supernova progenitors: the role of the 12^{12}C+12+^{12}C reaction

A precise knowledge of the masses of supernova progenitors is essential to answer various questions of modern astrophysics, such as those related to the dynamical and chemical evolution of Galaxies. In this paper we revise the upper bound for the mass of the progenitors of CO white dwarfs (\mup) and the lower bound for the mass of the progenitors of normal type II supernovae (\mups). In particular, we present new stellar models with mass between 7 and 10 \msun, discussing their final destiny and the impact of recent improvements in our understanding of the low energy rate of the \c12c12 reaction.Comment: To be published on the proceedings of NIC 201

mTOR-related cell-clearing systems in epileptic seizures, an update

Recent evidence suggests that autophagy impairment is implicated in the epileptogenic mechanisms downstream of mTOR hyperactivation. This holds true for a variety of genetic and acquired epileptic syndromes besides malformations of cortical development which are classically known as mTORopathies. Autophagy suppression is sufficient to induce epilepsy in experimental models, while rescuing autophagy prevents epileptogenesis, improves behavioral alterations, and provides neuroprotection in seizure-induced neuronal damage. The implication of autophagy in epileptogenesis and maturation phenomena related to seizure activity is supported by evidence indicating that autophagy is involved in the molecular mechanisms which are implicated in epilepsy. In general, mTOR-dependent autophagy regulates the proliferation and migration of inter-/neuronal cortical progenitors, synapse development, vesicular release, synaptic plasticity, and importantly, synaptic clustering of GABAA receptors and subsequent excitatory/inhibitory balance in the brain. Similar to autophagy, the ubiquitin–proteasome system is regulated downstream of mTOR, and it is implicated in epileptogenesis. Thus, mTOR-dependent cell-clearing systems are now taking center stage in the field of epilepsy. In the present review, we discuss such evidence in a variety of seizure-related disorders and models. This is expected to provide a deeper insight into the molecular mechanisms underlying seizure activit

Conditional Image-Text Embedding Networks

This paper presents an approach for grounding phrases in images which jointly learns multiple text-conditioned embeddings in a single end-to-end model. In order to differentiate text phrases into semantically distinct subspaces, we propose a concept weight branch that automatically assigns phrases to embeddings, whereas prior works predefine such assignments. Our proposed solution simplifies the representation requirements for individual embeddings and allows the underrepresented concepts to take advantage of the shared representations before feeding them into concept-specific layers. Comprehensive experiments verify the effectiveness of our approach across three phrase grounding datasets, Flickr30K Entities, ReferIt Game, and Visual Genome, where we obtain a (resp.) 4%, 3%, and 4% improvement in grounding performance over a strong region-phrase embedding baseline.Comment: ECCV 2018 accepted pape

UK Breastfeeding Helpline support: An investigation of influences upon satisfaction

Background Incentive or reward schemes are becoming increasingly popular to motivate healthy lifestyle behaviours. In this paper, insights from a qualitative and descriptive study to investigate the uptake, impact and meanings of a breastfeeding incentive intervention integrated into an existing peer support programme (Star Buddies) are reported. The Star Buddies service employs breastfeeding peer supporters to support women across the ante-natal, intra-partum and post-partum period. Methods In a disadvantaged area of North West England, women initiating breastfeeding were recruited by peer supporters on the postnatal ward or soon after hospital discharge to participate in an 8 week incentive (gifts and vouchers) and breastfeeding peer supporter intervention. In-depth interviews were conducted with 26 women participants who engaged with the incentive intervention, and a focus group was held with the 4 community peer supporters who delivered the intervention. Descriptive analysis of routinely collected data for peer supporter contacts and breastfeeding outcomes before and after the incentive intervention triangulated and retrospectively provided the context for the qualitative thematic analysis. Results A global theme emerged of 'incentives as connectors', with two sub-themes of 'facilitating connections' and 'facilitating relationships and wellbeing'. The incentives were linked to discussion themes and gift giving facilitated peer supporter access for proactive weekly home visits to support women. Regular face to face contacts enabled meaningful relationships and new connections within and between the women, families, peer supporters and care providers to be formed and sustained. Participants in the incentive scheme received more home visits and total contact time with peer supporters compared to women before the incentive intervention. Full participation levels and breastfeeding rates at 6-8 weeks were similar for women before and after the incentive intervention. Conclusion The findings suggest that whilst the provision of incentives might not influence women's intentions or motivations to breastfeed, the connections forged provided psycho-social benefits for both programme users and peer supporters

Min-Max Theorems for Packing and Covering Odd (u,v)(u,v)-trails

We investigate the problem of packing and covering odd $(u,v)$-trails in a graph. A $(u,v)$-trail is a $(u,v)$-walk that is allowed to have repeated vertices but no repeated edges. We call a trail odd if the number of edges in the trail is odd. Let $\nu(u,v)$ denote the maximum number of edge-disjoint odd $(u,v)$-trails, and $\tau(u,v)$ denote the minimum size of an edge-set that intersects every odd $(u,v)$-trail. We prove that $\tau(u,v)\leq 2\nu(u,v)+1$. Our result is tight---there are examples showing that $\tau(u,v)=2\nu(u,v)+1$---and substantially improves upon the bound of $8$ obtained in [Churchley et al 2016] for $\tau(u,v)/\nu(u,v)$. Our proof also yields a polynomial-time algorithm for finding a cover and a collection of trails satisfying the above bounds. Our proof is simple and has two main ingredients. We show that (loosely speaking) the problem can be reduced to the problem of packing and covering odd $(uv,uv)$-trails losing a factor of 2 (either in the number of trails found, or the size of the cover). Complementing this, we show that the odd-$(uv,uv)$-trail packing and covering problems can be tackled by exploiting a powerful min-max result of [Chudnovsky et al 2006] for packing vertex-disjoint nonzero $A$-paths in group-labeled graphs

Directional Next-Generation RNA Sequencing and Examination of Premature Termination Codon Mutations in Endoglin/Hereditary Haemorrhagic Telangiectasia

Hereditary haemorrhagic telangiectasia (HHT) is a disease characterised by abnormal vascular structures, and most commonly caused by mutations in ENG, ACVRL1 or SMAD4 encoding endothelial cell-expressed proteins involved in TGF-β superfamily signalling. The majority of mutations reported on the HHT mutation database are predicted to lead to stop codons, either due to frameshifts or direct nonsense substitutions. The proportion is higher for ENG (67%) and SMAD4 (65%) than for ACVRL1 (42%), p < 0.0001. Here, by focussing on ENG, we report why conventional views of these mutations may need to be revised. Of the 111 stop codon-generating ENG mutations, on ExPASy translation, all except one were premature termination codons (PTCs), sited at least 50-55 bp upstream of the final exon-exon boundary of the main endoglin isoform, L-endoglin. This strongly suggests that the mutated RNA species will undergo nonsense-mediated decay. We provide new in vitro expression data to support dominant negative activity of stable truncated endoglin proteins but suggest these will not generate HHT: the single natural stop codon mutation in L-endoglin (sited within 50-55 nucleotides of the final exon-exon boundary) is unlikely to generate functional protein since it replaces the entire transmembrane domain, as would 8 further natural stop codon mutations, if the minor S-endoglin isoform were implicated in HHT pathogenesis. Finally, next-generation RNA sequencing data of 7 different RNA libraries from primary human endothelial cells demonstrate that multiple intronic regions of ENG are transcribed. The potential consequences of heterozygous deletions or duplications of such regions are discussed. These data support the haploinsufficiency model for HHT pathogenesis, explain why final exon mutations have not been detected to date in HHT, emphasise the potential need for functional examination of non-PTC-generating mutations, and lead to proposals for an alternate stratification system of mutational types for HHT genotype-phenotype correlations