34 research outputs found
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses
Mean, standard deviation (SD), and comparison of cardiovascular parameters and of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device measured in subjects without classic major cardiovascular risk factors and subjects with at least one classic major cardiovascular risk factor.
<p>Significant differences are marked in bold. Abbreviations: LDL (low-density lipoprotein), HDL (high-density lipoprotein).</p
Mean, standard deviation (SD), and comparison of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device in the right eye, between the group with and without atheroma plaques in the right carotid.
<p>Mean, standard deviation (SD), and comparison of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device in the right eye, between the group with and without atheroma plaques in the right carotid.</p
Mean, standard deviation (SD), and comparison of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device in the group with and without cardiovascular risk according to the Framingham criteria.
<p>Mean, standard deviation (SD), and comparison of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device in the group with and without cardiovascular risk according to the Framingham criteria.</p
Mean, standard deviation (SD), and comparison of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device between the group without atheroma plaques and the group with at least one atheroma plaque.
<p>Mean, standard deviation (SD), and comparison of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device between the group without atheroma plaques and the group with at least one atheroma plaque.</p
Mean, standard deviation (SD), and comparison of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device in the left eye, between the group with and without atheroma plaques in the left carotid.
<p>Mean, standard deviation (SD), and comparison of retinal nerve fiber layer (RNFL) and macular thickness values obtained with the Cirrus High Definition optical coherence tomography (OCT) device in the left eye, between the group with and without atheroma plaques in the left carotid.</p
Bar graphs of optical coherence tomography measurements in microns.
<p>Representation in bar graphs of retinal nerve fiber layer (RNFL).</p