578 research outputs found
On apparent breaking the second law of thermodynamics in quantum transport studies
We consider a model for stationary electronic transport through a
one-dimensional chain of two leads attached to a perturbed central region
(quantum dot) in the regime where the theory proposed recently by Capek for a
similar model of phonon transport predicts the striking phenomenon of a
permanent current between the leads. This result based on a rigorous but
asymptotic Davies theory is at variance with the zero current yielded by direct
transport calculations which can be carried out in the present model. We find
the permanent current to be within the error of the asymptotic expansion for
finite couplings, and identify cancelling terms of the same order.Comment: 5 pages, 3 figure
Impact of the tip radius on the lateral resolution in piezoresponse force microscopy
We present a quantitative investigation of the impact of tip radius as well
as sample type and thickness on the lateral resolution in piezoresponse force
microscopy (PFM) investigating bulk single crystals. The observed linear
dependence of the width of the domain wall on the tip radius as well as the
independence of the lateral resolution on the specific crystal-type are
validated by a simple theoretical model. Using a Ti-Pt-coated tip with a
nominal radius of 15 nm the so far highest lateral resolution in bulk crystals
of only 17 nm was obtained
Breakdown of the Landauer bound for information erasure in the quantum regime
A known aspect of the Clausius inequality is that an equilibrium system
subjected to a squeezing \d S of its entropy must release at least an amount
|\dbarrm Q|=T|\d S| of heat. This serves as a basis for the Landauer
principle, which puts a lower bound for the heat generated by erasure
of one bit of information. Here we show that in the world of quantum
entanglement this law is broken. A quantum Brownian particle interacting with
its thermal bath can either generate less heat or even {\it adsorb} heat during
an analogous squeezing process, due to entanglement with the bath. The effect
exists even for weak but fixed coupling with the bath, provided that
temperature is low enough. This invalidates the Landauer bound in the quantum
regime, and suggests that quantum carriers of information can be much more
efficient than assumed so far.Comment: 13 pages, revtex, 2 eps figure
Come back Marshall, all is forgiven? : Complexity, evolution, mathematics and Marshallian exceptionalism
Marshall was the great synthesiser of neoclassical economics. Yet with his qualified assumption of self-interest, his emphasis on variation in economic evolution and his cautious attitude to the use of mathematics, Marshall differs fundamentally from other leading neoclassical contemporaries. Metaphors inspire more specific analogies and ontological assumptions, and Marshall used the guiding metaphor of Spencerian evolution. But unfortunately, the further development of a Marshallian evolutionary approach was undermined in part by theoretical problems within Spencer's theory. Yet some things can be salvaged from the Marshallian evolutionary vision. They may even be placed in a more viable Darwinian framework.Peer reviewedFinal Accepted Versio
Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients
Background: Burn patients are prone to infections which often necessitate broad antibiotic coverage. Vancomycin is a common antibiotic after burn injury and is administered alone (V), or in combination with imipenem-cilastin (V/IC) or piperacillin-tazobactam (V/PT). Sparse reports indicate that the combination V/PT is associated with increased renal dysfunction. The purpose of this study was to evaluate the short-term impact of the three antibiotic administration types on renal dysfunction.
Methods: All pediatric and adult patients admitted to our centers between 2004 and 2016 with a burn injury were included in this retrospective review if they met the criteria of exposition to either V, V/IC, or V/PT for at least 48 h, had normal baseline creatinine, and no pre-existing renal dysfunction. Creatinine was monitored for 7 days after initial exposure; the absolute and relative increase was calculated, and patient renal outcomes were classified according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria depending on creatinine increases and estimated creatinine clearance. Secondary endpoints (demographic and clinical data, incidences of septicemia, and renal replacement therapy) were analyzed. Antibiotic doses were modeled in logistic and linear multivariable regression models to predict categorical KDIGO events and relative creatinine increase.
Results: Out of 1449 patients who were screened, 718 met the inclusion criteria, 246 were adults, and 472 were children. Between the study cohorts V, V/IC, and V/PT, patient characteristics at admission were comparable. V/PT administration was associated with a statistically higher serum creatinine, and lower creatinine clearance compared to patients receiving V alone or V/IC in adults and children after burn injury. The incidence of KDIGO stages 1, 2, and 3 was higher after V/PT treatment. In children, the incidence of KDIGO stage 3 following administration of V/PT was greater than after V/IC. In adults, the incidence of renal replacement therapy was higher after V/PT compared with V or V/IC. Multivariate modeling demonstrated that V/PT is an independent predictor of renal dysfunction.
Conclusion: Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in pediatric and adult burn patients when compared to vancomycin alone or vancomycin plus imipenem-cilastin. The mechanism of this increased nephrotoxicity remains elusive and warrants further scientific evaluation
On the V-type asteroids outside the Vesta family. I. Interplay of nonlinear secular resonances and the Yarkovsky effect: the cases of 956 Elisa and 809 Lundia
Among the largest objects in the main belt, asteroid 4 Vesta is unique in
showing a basaltic crust. It is also the biggest member of the Vesta family,
which is supposed to originate from a large cratering event about 1 Gyr ago
(Marzari et al. 1996). Most of the members of the Vesta family for which a
spectral classification is available show a V-type spectra. Before the
discovery of 1459 Magnya (Lazzaro et al. 2000) and of several V-type NEA (Xu
1995), all the known V-type asteroids were members of the Vesta family.
Recently two V-type asteroids, 809 Lundia and 956 Elisa, (Florczak et al. 2002)
have been discovered well outside the limits of the family, near the Flora
family. We currently know 22 V-type asteroids outside the family, in the inner
asteroid belt. In this work we investigate the possibility that these objects
are former family members that migrated to their current positions via the
interplay of Yarkovsky effect and nonlinear secular resonances. The main
dynamical feature of 956 Elisa and 809 Lundia is that they are currently inside
the 2(g-g6)+s-s6 (z2 by Milani and Knezevic, 1993) secular resonance. Our
investigations show that members of the Vesta dynamical family may drift in
three-body and weak secular resonances until they are captured in the strong z2
secular resonance. Only asteroids with diameters larger than 16 km can remain
in one of the three-body or secular resonances long enough to reach the region
of the z2 resonance. This two-step mechanism of capture into the z2 resonance
could explain: i) the current resonant orbits of 956 Elisa and 809 Lundia, ii)
why their size is significantly larger than that of the typical member of the
Vesta family, and iii) provide a lower limit on the Vesta family age.Comment: 14 pages, 10 figures, 3 tables. Accepted for publication in A&
Hydrogel coated monoliths for enzymatic hydrolysis of penicillin G
The objective of this work was to develop a hydrogel-coated monolith for the entrapment of penicillin G acylase (E. coli, PGA). After screening of different hydrogels, chitosan was chosen as the carrier material for the preparation of monolithic biocatalysts. This protocol leads to active immobilized biocatalysts for the enzymatic hydrolysis of penicillin G (PenG). The monolithic biocatalyst was tested in a monolith loop reactor (MLR) and compared with conventional reactor systems using free PGA, and a commercially available immobilized PGA. The optimal immobilization protocol was found to be 5 g lâ1 PGA, 1% chitosan, 1.1% glutaraldehyde and pH 7. Final PGA loading on glass plates was 29 mg mlâ1 gel. For 400 cpsi monoliths, the final PGA loading on functionalized monoliths was 36 mg mlâ1 gel. The observed volumetric reaction rate in the MLR was 0.79 mol sâ1 mâ3monolith. Apart from an initial drop in activity due to wash out of PGA at higher ionic strength, no decrease in activity was observed after five subsequent activity test runs. The storage stability of the biocatalysts is at least a month without loss of activity. Although the monolithic biocatalyst as used in the MLR is still outperformed by the current industrial catalyst (immobilized preparation of PGA, 4.5 mol sâ1 mâ3catalyst), the rate per gel volume is slightly higher for monolithic catalysts. Good activity and improved mechanical strength make the monolithic bioreactor an interesting alternative that deserves further investigation for this application. Although moderate internal diffusion limitations have been observed inside the gel beads and in the gel layer on the monolith channel, this is not the main reason for the large differences in reactor performance that were observed. The pH drop over the reactor as a result of the chosen method for pH control results in a decreased performance of both the MLR and the packed bed reactor compared to the batch system. A different reactor configuration including an optimal pH profile is required to increase the reactor performance. The monolithic stirrer reactor would be an interesting alternative to improve the performance of the monolith-PGA combination
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