Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing

Quasiperiodic Solutions of the Fibre Optics Coupled Nonlinear Schr{\"o}dinger Equations

We consider travelling periodical and quasiperiodical waves in single mode fibres, with weak birefringence and under the action of cross-phase modulation. The problem is reduced to the ``1:2:1" integrable case of the two-particle quartic potential. A general approach for finding elliptic solutions is given. New solutions which are associated with two-gap Treibich-Verdier potentials are found. General quasiperiodic solutions are given in terms of two dimensional theta functions with explicit expressions for frequencies in terms of theta constants. The reduction of quasiperiodic solutions to elliptic functions is discussed.Comment: 24 page

Less Cookbook and More Research! Synthetic Efforts Toward JBIR-94 and JBIR-125: a Student-Designed Research Project in a Sophomore Organic Chemistry Lab

In light of the meaningful learning gains that can be obtained through a genuine research experience, chemistry educators have had a longstanding interest in making teaching labs less “cookbook-like” and more research-driven [1]. With this mindset, we recently restructured our two-semester sophomore organic chemistry lab course to include a synthesis project that was chosen, designed, and carried out by students. This led to progress toward the syntheses of JBIR-94 and JBIR-125, two antioxidative/anticancer natural products that have yet to be assembled through organic chemistry. The major drawback of our course redesign is that it requires close supervision by an instructor or TA experienced in synthetic chemistry and is limited to small class sizes. Its up-front cost is also prohibitive; however, this can be minimized by employing synthetic steps that involve reagents already available on-site. The advantage of this restructuring is encapsulated by highly-positive student feedback and enthusiasm, which led all participating students to continue working on the project after the semester had ended. Exam performance is also discussed. For reference, complete and reproducible experimental details and full copies of student evaluation results are included as Supporting Materials

The UNSW Extrasolar Planet Search: Methods and First Results from a Field Centred on NGC 6633

We report on the current status of the University of New South Wales Extrasolar Planet Search project, giving details of the methods we use to obtain millimagnitude precision photometry using the 0.5m Automated Patrol Telescope. We use a novel observing technique to optimally broaden the PSF and thus largely eliminate photometric noise due to intra-pixel sensitivity variations on the CCD. We have observed 8 crowded Galactic fields using this technique during 2003 and 2004. Our analysis of the first of these fields (centred on the open cluster NGC 6633) has yielded 49 variable stars and 4 shallow transit candidates. Follow-up observations of these candidates have identified them as eclipsing binary systems. We use a detailed simulation of our observations to estimate our sensitivity to short-period planets, and to select a new observing strategy to maximise the number of planets detected.Comment: 16 pages, 9 figures, version published in MNRAS Updated figures, references, and additional discussion in section

Occupational balance: What tips the scales for new students?

The open question, ‘What prevents you from reaching occupational balance?’, was posed within a questionnaire aimed at exploring the meanings of occupation, health and wellbeing with a cohort of first-year occupational therapy students during their initial few weeks at university. Their written responses to the question about occupational balance were analysed and are discussed in this paper. Not surprisingly, occupational balance appeared to be achieved by only a few and more by chance than design. People, time and money factors were identified as the main impediments to achieving occupational balance, with psychological and emotional pressures being at the forefront. Interestingly, despite these barriers, the overall educational benefit of considering the occupational balance question in this way raised the students’ awareness of its relationship to health and wellbeing. This increased awareness might have longer-term health benefits, both personally and professionally, which would be worthy of further research

Submergence times and abundance estimation of blue whales off Sri Lanka

Very little is known about the blue whale populations in the waters of Sri Lanka. A first attempt at estimating their relative abundances using DISTANCE sampling methods is currently underway in the waters off the southern coast of the island. Surfacing behavior was quantified from focal follows of individual blue whales between January and March 2011. Estimates of submergence times will be used for generating more precise abundance estimates. Individuals were followed from a 32-foot vessel to observe surfacing patterns and breathing behaviour in the presence and absence of whalewatching boats. Time at first surface, length of surface interval, number of blows and final dive time were collected. The data gathered was analysed using a hidden Markov model (HMM) to identify whether dive duration was uniform or whether dives could be classified using surface interval and submergence time. The preliminary results show that the whales performed two types of dives; ‘regular’ and ‘deep’ dives with Inter Breath Intervals (IBI) of 22.0s (SD=4.7) and 635.6s (SD=405.4) respectively. Blue Whales off southern Sri Lanka spend 75% of their time performing ‘regular’ dives. Accordingly; we estimated that their mean IBI was approximately 173s. These preliminary results obtained using HMM may provide a more accurate correction factor than that obtained from the raw data. This may refine estimates of whale density and abundance for the area