Foucault Revisited

Janet Semple wrote that Panopticon was the only book by Jeremy Bentham that Michel Foucault had ever read. It follows that Bentham scholars have considered Foucault’s Discipline and Punish as both a critical and an incomplete analysis of Bentham’s thought. The recent 2004 edition of Foucault’s unpublished lectures at the College de France and the 2006 seminal paper by Christian Laval, a French Bentham scholar from the Centre Bentham, give grounds for reappraising received ideas on the relationship between Foucault and Bentham. Foucault’s understanding of Bentham clearly goes beyond concepts of surveillance to focus on the idea of governance; the latter is more in tune with contemporary Bentham studies. Concepts used by Foucault in his lectures, such as that of ‘frugal/frugality’ not only derive from Bentham’s writings but are more relevant to an analysis of Bentham’s philosophy than the corresponding concept ‘economical/economy’ used by contemporary scholars. Over the years, Foucault seems to have moved on from an incomplete and therefore inaccurate knowledge of Bentham to a deeper understanding of his work. This paper not only challenges Bentham scholars’ prejudices against Foucault’s analysis but also aims at overcoming received ideas about Bentham’s philosophy among the French academic community

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C

Technique d'homogénéisation pour un stent en cas de d'AAA

International audienceThis studie prsent an homogeneization technic usefull for stent prosthesis (use in case of AAA) to reduce calculation time and make possible the numerical simulation in real time by means of per-operatory imagesCette étude présente une méthode d'homogénéisation appliquée à des endopro-thèses (utilisées en cas d'AAA) afin de réduire le temps de calcul de ces structures complexes et rendre la simulation numérique de leur comportement en temps réel possible grâce à des images per-opératoires