55 research outputs found
The effects of acidosis on eNOS in the systemic vasculature: a focus on early postnatal ontogenesis
The activity of many vasomotor signaling pathways strongly depends on extracellular/intracellular pH. Nitric oxide (NO) is one of the most important vasodilators produced by the endothelium. In this review, we present evidence that in most vascular beds of mature mammalian organisms metabolic or respiratory acidosis increases functional endothelial NO-synthase (eNOS) activity, despite the observation that direct effects of low pH on eNOS enzymatic activity are inhibitory. This can be explained by the fact that acidosis increases the activity of signaling pathways that positively regulate eNOS activity. The role of NO in the regulation of vascular tone is greater in early postnatal ontogenesis compared to adulthood. Importantly, in early postnatal ontogenesis acidosis also augments functional eNOS activity and its contribution to the regulation of arterial contractility. Therefore, the effect of acidosis on total peripheral resistance in neonates may be stronger than in adults and can be one of the reasons for an undesirable decrease in blood pressure during neonatal asphyxia. The latter, however, should be proven in future studies
Effects of anemia and mineral metabolism disorder management on the quality of life of chronic kidney disease patients undergoing dialysis
Anemia and mineral metabolism disorder (MMD) are common complications of the chronic kidney disease (CKD) and result in more complicated treatment plans, longer hospital stays as well as reduced quality of life of such patients. Appropriate management of this conditions can reduce the risk of developing further complications and improve general health outcomes
Modern approaches to inhalation treatment of bronchoobstructive diseases from dentist's point of view
ΠΠ΅ΡΠΎΠ΄ΠΈΡΠ½Ρ ΠΏΡΠ΄Ρ ΠΎΠ΄ΠΈ Π΄ΠΎ Π·Π±ΠΎΡΡ ΡΠ° Π°Π½Π°Π»ΡΠ·Ρ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΡ Π²ΠΎΠ»ΠΎΠ³ΠΈ Π²ΠΈΠ΄ΠΈΡ ΡΠ²Π°Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²ΡΡΡΡ
Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π² ΠΏΡΠ»ΡΠΌΠΎΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΊΠ°ΡΠ΄ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠ° Π²Π»Π°Π³ΠΈ Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄ΡΡ
Π° (ΠΠΠ). Π‘ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΠΠ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΎΠ±ΡΠ΅ΠΏΡΠΈΠ½ΡΡΡΡ
ΡΡΠ°Π½Π΄Π°ΡΡΠΎΠ² Π΅Π³ΠΎ ΡΠ±ΠΎΡΠ° ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² Π½Π΅ΠΌ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π΅ΡΠ΅ΡΡΠ², ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΠ»ΡΡΡΠ° Π½ΠΈΠ·ΠΊΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ. ΠΡΠΏΠ»Π΅ΡΠΊ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠ° ΠΊ Π΄Π°Π½Π½ΠΎΠΌΡ Π²ΠΎΠΏΡΠΎΡΡ ΠΏΡΠΈΠ²Π΅Π» ΠΊ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅Π»Π΅Π²ΠΎΠΉ Π³ΡΡΠΏΠΏΡ American Thoracic Society ΠΈ European Respiratory Society ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΠΏΠΎ Π·Π°Π±ΠΎΡΡ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠ°. ΠΠ°ΠΌΠΈ Π±ΡΠ»ΠΈ ΠΈΠ·ΡΡΠ΅Π½Ρ ΠΈ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ATS/ERS ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ Π°Π»Π³ΠΎΡΠΈΡΠΌ Π·Π°Π±ΠΎΡΠ° ΠΠΠ
Methodical approaches to collecting and analyzing the exhaled breath condensate
Currently, one of the promising non-invasive diagnostic methods in pulmonology, cardiology, endocrinology, oncology is the study of the exhaled breath condensate (EBC). A significant limitation of the study of EBC in clinical practice is the absence of generally accepted standards for its collection and study of the content of biological substances containing ultra low concentrations in it. The growing scientific and practical interest in this issue led to the organization of the target group American Thoracic Society and the European Respiratory Society and the development of recommendations for the collection of condensate. We have studied and analyzed the recommendations of ATS / ERS and developed an algorithm for sampling EBC
Peroxisome proliferator-activated receptors in kidney physiology and pathology
Π Π΅ΡΠ΅ΠΏΡΠΎΡΡ, Π°ΠΊΡΠΈΠ²ΠΈΡΡΡΡΠΈΠ΅ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΏΠ΅ΡΠΎΠΊΡΠΈΡΠΎΠΌ (PPAR), ΡΠ΄Π΅ΡΠ½ΡΠ΅ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ ΠΈΠ· ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ², ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π½Π°Π΄ ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΡΠΌ ΠΈ ΠΆΠΈΡΠΎΠ²ΡΠΌ ΠΎΠ±ΠΌΠ΅Π½ΠΎΠΌ, ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·ΠΎΠΌ, Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ ΡΠΎΡΡΠ΄ΠΎΠ². ΠΡΠ΅ ΡΡΠΈ ΡΠΈΠΏΠ° PPAR ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Ρ Π² ΠΏΠΎΡΠΊΠ°Ρ
ΠΈ ΠΈΠ³ΡΠ°ΡΡ Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ², Π²ΡΠΏΠΎΠ»Π½ΡΡ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ, ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ ΠΈ Π°Π½ΡΠΈΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ ΡΡΠ½ΠΊΡΠΈΡ ΠΏΡΠΈ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΡΠΎΠΏΠ°ΡΠΈΠΈ, Π³Π»ΠΎΠΌΠ΅ΡΡΠ»ΠΎΠ½Π΅ΡΡΠΈΡΠ΅ ΠΈ ΠΎΡΡΡΠΎΠΌ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ
Surgical treatment of wounded persons with complicated thoracic damages
Objective. To improve the results of complex surgical treatment of wounded and injured persons with thoracic trauma, complicated by bronchopleural fistulas, pleural empyema and defects in the thoracic wall soft tissues, basing on introduction of the proposed procedure of vacuum therapy in combination with bronchoscopic obturation of certain bronchus.
Materials and methods. Analysis of results of the complex surgical help delivery for 54 wounded persons with defects of the thoracic wall soft tissues, broncho-pleural fistulas and pleural empyema, caused by the combat thoracic trauma, on ΠΠΠ and ΠV levels of medical support while conduction of the Antiterrorist operation/Operation of the Joined Forces (the main group) and 73 injured persons with thoracic trauma of the peace period (the comparison group) in the 2014 - 2019 yrs period was conducted.
Results. Improvement of complex surgical treatment of the wounded and damaged persons with thoracic trauma and defects of the thoracic wall soft tissues have permitted to reduce the complications frequency by 6.7%, and lethality - by 9.2% in the main group.
Conclusion. There was proposed a procedure of vacuum therapy, ultrasound cavitation together with bronchoscopic bronchial obturation for its fistula, which have proved its efficacy in complex surgical treatment of severely wounded persons with the gun-shot thoracic damages and presence of combination of pleural empyema, bronchial fistula and defects of soft tissues
Acute intake of a large dose of cardiac glycosides by a young male
One of the most toxic drugs is a group of cardiac glycosides. Having a very narrow spectrum of therapeutic action, cardiac glycosides are able to cause serious intoxication with complications including arrhythmias and conduction disorder, which often lead to death. Considering the mortality rates in cases of medication poisoning, it is important to pay special attention and care to prevent, diagnose and treat such medical conditions. The 28-year-old male presents with intoxication and arrhythmia after he unintentionally took a wrong medication. A timely appeal for medical help and appropriate treatment helped to avoid serious consequences of glycoside intoxication
The features of risk factors, systemic inflammation, and endothelial dysfunction in patients with asthma concurrent with coronary heart disease
Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΡΠ²ΠΈΡΡ ΡΠ°ΠΊΡΠΎΡΡ ΡΠΈΡΠΊΠ° (Π€Π ), ΠΎΡΠ΅Π½ΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ ΠΈ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ (ΠΠ) Π½Π° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΡ (ΠΠ) Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ ΡΠ΅ΡΠ΄ΡΠ° (ΠΠΠ‘) ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΡΡΠ΅ΠΏΠ΅Π½Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠΈΠ»ΠΈ 50 Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 40β75 Π»Π΅Ρ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΡΡΠ°Π΄Π°Π»ΠΈ ΠΠΠ‘. Π£ Π²ΡΠ΅Ρ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΡΡΠ½ΠΊΡΠΈΡ Π²Π½Π΅ΡΠ½Π΅Π³ΠΎ Π΄ΡΡ
Π°Π½ΠΈΡ (Π€ΠΠ), ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠΊΠ°ΡΠ΄ΠΈΠΎΠ³ΡΠ°ΠΌΠΌΡ, Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ΅ Π΄Π°Π²Π»Π΅Π½ΠΈΠ΅ ΠΈ Π°Π½ΡΡΠΎΠΏΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ, ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π²Π΅Π»ΠΎΡΡΠ³ΠΎΠΌΠ΅ΡΡΠΈΡ. ΠΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ ΡΠ±ΠΎΡ Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π°Π»Π»Π΅ΡΠ³ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π°Π½Π½ΡΡ
, ΠΎΡΠ΅Π½ΠΊΡ Π€Π ΠΈ Π±Π°Π·ΠΈΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ. ΠΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΎΡΠ΅Π½ΠΊΡ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΌΠΎΡΠΈ, ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ Π΄ΠΈΠ°ΠΌΠ΅ΡΡΠ° ΠΏΠ»Π΅ΡΠ΅Π²ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠΈ (ΠΠ) ΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΡΠΊΠΎΡΠΎΡΡΠΈ ΠΊΡΠΎΠ²ΠΎΡΠΎΠΊΠ° (TAMX) ΠΏΡΠΈ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΈ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΎΡ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ Π²Π°Π·ΠΎΠ΄ΠΈΠ»Π°ΡΠ°ΡΠΈΠΈ (ΠΠΠΠ ΠΈ ΠΠΠΠΠ).
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΠ Π½Π° ΡΠΎΠ½Π΅ ΠΠΠ‘ Π°ΡΡΠΎΡΠΈΠΈΡΡΠ΅ΡΡΡ Ρ ΡΠ°ΠΊΠΈΠΌΠΈ Π€Π , ΠΊΠ°ΠΊ ΠΆΠ΅Π½ΡΠΊΠΈΠΉ ΠΏΠΎΠ» (66%), Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΠ (40%) ΠΈ ΠΠΠ‘ (76%), ΠΠ (86%), ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ (42%), ΠΊΡΡΠ΅Π½ΠΈΠ΅ (7%), Π½Π°Π»ΠΈΡΠΈΠΈ Π²ΡΠ΅Π΄Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π° ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅ (20%) ΠΈ Π΄ΠΈΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡ. Π Ρ
ΠΎΠ΄Π΅ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ 16 (32%) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ Π½Π° ΡΠΎΠ½Π΅ ΠΠΠ‘ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΡΠ΅Π°ΠΊΡΠΈΡ Π½Π° Π½Π°Π»ΠΈΡΠΈΠ΅ Π‘-ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° (Π‘Π Π), Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° Π² ΠΊΡΠΎΠ²ΠΈ. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΠΠ‘ ΠΏΡΠΈ ΠΏΡΠΎΠ±Π΅ Ρ ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΠ΅ΠΌΠΈΠ΅ΠΉ Π΄ΠΈΠ°ΠΌΠ΅ΡΡ ΠΠ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π»ΡΡ Π΄ΠΎ 4,27Β±0,3 ΠΌΠΌ, ΠΏΡΠΈ ΠΏΡΠΎΠ±Π΅ Ρ Π½ΠΈΡΡΠΎΠ³Π»ΠΈΡΠ΅ΡΠΈΠ½ΠΎΠΌ β Π΄ΠΎ 4,54Β±0,03 ΠΌΠΌ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΈΡΡ
ΠΎΠ΄Π½ΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ (p<0,01). Π£ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π° Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠ΅ ΠΈ ΡΠ°ΡΡΡΠ΅ ΡΠΈΠΌΠΏΡΠΎΠΌΡ Π±ΠΎΠ»Π΅Π·Π½ΠΈ, Π²ΡΡΠΎΠΊΠ°Ρ ΡΠ°ΡΡΠΎΡΠ° ΠΎΠ±ΠΎΡΡΡΠ΅Π½ΠΈΠΉ, Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ Π€ΠΠ ΠΈ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΡ Π² Π±ΡΠΎΠ½Ρ
ΠΎΠ»ΠΈΡΠΈΠΊΠ°Ρ
Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½ΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ.
ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠΈ ΠΠ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΠΠ‘ Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ ΠΈΠ³ΡΠ°ΡΡ Π€Π , ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ: ΠΆΠ΅Π½ΡΠΊΠΈΠΉ ΠΏΠΎΠ», Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎΡΡΡ, ΠΠ, ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ ΠΈ Π΄ΠΈΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΠΠΠ, ΠΠΠΠΠ ΠΈ Π’ΠΠΠ₯, Π³ΠΈΠΏΠ΅ΡΡ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π΅ΠΌΠΈΡ ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Π‘Π Π Π² ΠΊΡΠΎΠ²ΠΈ. ΠΠ°Π·ΠΈΡΠ½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΠΠ‘ Π½Π΅ Π±ΡΠ»Π° ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ Ρ 70% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π½Π΅ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π½Π°Π΄ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ
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