Split-Stirling-cycle displacer linear-electric drive

The retrofit of a 1/4-W split-Stirling cooler with a linear driven on the displacer was achieved and its performance characterized. The objective of this work was to demonstrate that a small linear motor could be designed to meet the existing envelope specifications of the cooler and that an electric linear drive on the displacer could improve the cooler's reliability and performance. The paper describes the characteristics of this motor and presents cooler test results

Inherited thrombophilia in young Indian adults presenting with thrombotic vascular events

Background: There is limited Indian data available regarding inherited thrombophilias. This study was to determine the prevalence of inherited thrombophilias in young Indian patients presenting with thrombotic events.Methods: This study was done at a tertiary hospital in Western India over a period of 20 months. Epidemiological, clinical and laboratory data was recorded of all consecutive patients aged 16 to 45 admitted with arterial and venous thrombotic vascular events. Blood samples for the thrombophilia profile were sent. Data was tabulated and analyzed using microsoft excel and graph pad software.Results: 49 patients aged 15 to 45 years, admitted with thrombotic vascular events a period of 20 months were included. 26 (53.1%) were male. The mean age was 22.2±7 years. 20 (40.8%) patients; 10 (38.5%) males and 10 (43.5%) females had at least one thrombophilia. The commonest thrombophilia in both arterial and venous thrombotic events was hyperhomocysteinemia.Conclusions: Young patients with thrombotic vascular events should be tested for thrombophilias since they are an important risk factor in this subset of patients

Are Twin Pregnancies Complicated by Weight Discordance or Fetal Growth Restriction at Higher Risk of Preeclampsia?

Studies have reported controversial findings on the association between fetal growth restriction (FGR) or intertwin weight discordance and the risk of hypertensive disorders of pregnancy (HDP) in twin pregnancies. The aim of this study was to investigate the association between twin growth disorders and HDP. Twin pregnancies resulting in two live births at St George's Hospital between 2000 and 2019 were included. FGR or small-for-gestational-age (SGA) at birth was assessed using singleton and twin reference charts. Intertwin discordance [(large birthweight - small birthweight)/(large birthweight) × 100%)] was calculated. Logistic regression models were performed. SGA (aOR 2.34, 95% CI 1.60-3.44, p < 0.001), intertwin discordance ≥25% (aOR 2.10, 95% CI 1.26-3.49, p = 0.004) and their co-existence (aOR 2.03, 95% CI 1.16-3.54, p = 0.013) were significantly associated with HDP. After adjusting for the known maternal risk factors of HDP and the intertwin discordance, SGA (using the twin charts) was the strongest independent risk factor associated with HDP (aOR 2.12, 95% CI 1.40-3.22, p < 0.001) and preeclampsia (aOR 2.34, 95% CI 1.45-3.76, p < 0.001). This study highlights that the presence of at least one SGA twin is significantly associated with HDP during pregnancy. Therefore, maternal blood pressure should be closely monitored in twin pregnancies complicated by SGA with or without intertwin discordance

Studies on production of peptide antibiotic by thermotolerant Bacillus sp.

The soil sample was collected and screened for isolation of higher antibiotic producing bacterial strain. The isolated bacterial strain was tentatively identified as Bacillus sp. by biochemical characters using Bergey&rsquo;s manual. The present study is focused on the optimization of different parameters for production of peptide antibiotic (Bacitracin) using synthetic medium. The antibacterial activity of isolate was analyzed against S. aureus. The nutritional ingredients for bacitracin production were found as glucose (1%) and L-glutamic acid (0.5 %) as carbon and nitrogen source respectively. The prominent bacitracin production was obtained after 48 hrs incubation at 40&deg;C temperature and at 7 pH

Development of a perfect prognosis probabilistic model for prediction of lightning over south-east India

A prediction model based on the perfect prognosis method was developed to predict the probability of lightning and probable time of its occurrence over the south-east Indian region. In the perfect prognosis method, statistical relationships are established using past observed data. For real time applications, the predictors are derived from a numerical weather prediction model. In the present study, we have developed the statistical model based on Binary Logistic Regression technique. For developing the statistical model, 115 cases of lightning that occurred over the south-east Indian region during the period 2006–2009 were considered. The probability of lightning (yes or no) occurring during the 12-hour period 0900–2100 UTC over the region was considered as the predictand. The thermodynamic and dynamic variables derived from the NCEP Final Analysis were used as the predictors. A three-stage strategy based on Spearman Rank Correlation, Cumulative Probability Distribution and Principal Component Analysis was used to objectively select the model predictors from a pool of 61 potential predictors considered for the analysis. The final list of six predictors used in the model consists of the parameters representing atmospheric instability, total moisture content in the atmosphere, low level moisture convergence and lower tropospheric temperature advection. For the independent verifications, the probabilistic model was tested for 92 days during the months of May, June and August 2010. The six predictors were derived from the 24-h predictions using a high resolution Weather Research and Forecasting model initialized with 00 UTC conditions. During the independent period, the probabilistic model showed a probability of detection of 77% with a false alarm rate of 35%. The Brier Skill Score during the independent period was 0.233, suggesting that the prediction scheme is skillful in predicting the lightning probability over the south-east region with a reasonable accuracy

Fracture in Mode I using a Conserved Phase-Field Model

We present a continuum phase-field model of crack propagation. It includes a phase-field that is proportional to the mass density and a displacement field that is governed by linear elastic theory. Generic macroscopic crack growth laws emerge naturally from this model. In contrast to classical continuum fracture mechanics simulations, our model avoids numerical front tracking. The added phase-field smoothes the sharp interface, enabling us to use equations of motion for the material (grounded in basic physical principles) rather than for the interface (which often are deduced from complicated theories or empirical observations). The interface dynamics thus emerges naturally. In this paper, we look at stationary solutions of the model, mode I fracture, and also discuss numerical issues. We find that the Griffith's threshold underestimates the critical value at which our system fractures due to long wavelength modes excited by the fracture process.Comment: 10 pages, 5 figures (eps). Added 2 figures and some text. Removed one section (and a figure). To be published in PR

Comparison of ductus venosus Doppler and cerebroplacental ratio for the prediction of adverse perinatal outcome in high-risk pregnancies before and after 34 weeks.

INTRODUCTION: The objective of the study was to compare the accuracy of the ductus venosus pulsatility index (DV PI) with that of the cerebroplacental ratio (CPR) for the prediction of adverse perinatal outcome at two gestational ages:  0.05), and did not improve the predictive accuracy of CPR for adverse perinatal outcome (AUC 0.88, 95% CI: 0.79-0.97, AIC 52.9, p  0.05), that did not improve the CPR ability to predict adverse perinatal outcome (AUC 0.80, 95% CI: 0.67-0.92, AIC 106.8, p < 0.0001). The predictive accuracy of CPR prior to 34 weeks persisted when the gestational age at delivery was included in the model (AUC 0.91, 95% CI: 0.81-1.00, AIC 46.3, p < 0.0001, vs AUC 0.86, 95% CI: 0.72-1, AIC 56.1, p < 0.0001), and therefore was not determined by prematurity. CONCLUSIONS: CPR predicts adverse perinatal outcome better than DV PI, regardless of gestational age. Larger prospective studies are needed to delineate the role of ultrasound tools of fetal wellbeing assessment in predicting and preventing adverse perinatal outcome

Risk factors associated with stillbirth and adverse perinatal outcomes in dichorionic twin pregnancies complicated by selective fetal growth restriction: a cohort study.

OBJECTIVE: The main aim of this study was to investigate the perinatal outcomes of dichorionic twin pregnancies complicated by selective fetal growth restriction (sFGR). DESIGN: Retrospective cohort study. SETTING: Tertiary reference centre. POPULATION: Dichorionic twin pregnancies complicated by sFGR between 2000 and 2019 in St George's University Hospital. METHODS: Regression analyses were performed using generalised linear models and mixed-effects generalised linear models where appropriate to account for pregnancy level dependency in variables. Time to event analyses were performed with mixed-effects Cox regression models. MAIN OUTCOME MEASURES: Stillbirth, neonatal death or neonatal unit admission with morbidity in one or both twins. RESULTS: A total of 102 (of 2431 dichorionic twin pregnancies) pregnancies complicated by sFGR were included in the study. The Cochrane-Armitage test revealed a significant trend for increased adverse perinatal outcome rates with more severe forms of umbilical artery flow impedance, i.e. reversed, absent, positive with resistant flow and positive flow without resistance. A multivariable model including maternal and conception characteristics had poor predictive accuracy for stillbirth (area under the curve: 0.68, 95% confidence interval [CI] 0.55-0.81) and composite adverse perinatal outcomes (area under the curve: 0.58, 95% CI 0.47-0.70). When umbilical artery Doppler parameters were added to the models, the area under the curve values improved to 0.95 (95% CI 0.89-0.99) and 0.83 (95% CI 0.73-0.92) for stillbirth and composite adverse perinatal outcomes, respectively. CONCLUSION: In dichorionic twin pregnancies complicated by sFGR, the umbilical artery Z-scores were associated with both intrauterine death and adverse perinatal outcomes

Perinatal Outcomes of Small for Gestational Age in Twin Pregnancies: Twin vs. Singleton Charts.

Twin pregnancies are commonly assessed using singleton growth and birth weight reference charts. This practice has led to a significant number of twins labelled as small for gestational age (SGA), causing unnecessary interventions and increased risk of iatrogenic preterm birth. However, the use of twin-specific charts remains controversial. This study aims to assess whether twin-specific estimated fetal weight (EFW) and birth weight (BW) charts are more predictive of adverse outcomes compared to singleton charts. Centiles of EFW and BW were calculated using previously published singleton and twin charts. Categorical data were compared using Chi-square or McNemar tests. The study included 1740 twin pregnancies, with the following perinatal adverse outcomes recorded: perinatal death, preterm birth <34 weeks, hypertensive disorders of pregnancy (HDP) and admissions to the neonatal unit (NNU). Twin-specific charts identified prenatally and postnatally a smaller proportion of infants as SGA compared to singleton charts. However, twin charts showed a higher percentage of adverse neonatal outcomes in SGA infants than singleton charts. For example, perinatal death (SGA 7.2% vs. appropriate for gestational age (AGA) 2%, p < 0.0001), preterm birth <34 weeks (SGA 42.1% vs. AGA 16.4%, p < 0.0001), HDP (SGA 21.2% vs. AGA 13.5%, p = 0.015) and NNU admissions (SGA 69% vs. AGA 24%, p < 0.0001), when compared to singleton charts (perinatal death: SGA 2% vs. AGA 1%, p = 0.029), preterm birth <34 weeks: (SGA 20.6% vs. AGA 17.4%, p = 0.020), NNU admission: (SGA 34.5% vs. AGA 23.9%, p < 0.000). There was no significant association between HDP and SGA using the singleton charts (p = 0.696). In SGA infants, according to the twin charts, the incidence of abnormal umbilical artery Doppler was significantly more common than in SGA using the singleton chart (27.0% vs. 8.1%, p < 0.001). In conclusion, singleton charts misclassify a large number of twins as at risk of fetal growth restriction. The evidence suggests that the following twin-specific charts could reduce unnecessary medical interventions prenatally and postnatally

Simulated dynamics and thermodynamics processes leading to the rapid intensification of rare tropical cyclones over the North Indian Oceans

The life cycle dynamics and intensification processes of three long-duration tropical cyclones (TCs), viz., Fani (2019), Luban (2018), and Ockhi (2017) formed over the North Indian Ocean (NIO) have been investigated by developing a high-resolution (6 km × 6 km) mesoscale analysis using WRF and En3DVAR data assimilation system. The release of CAPE in nearly saturated middle-level relative humidity caused intense diabatic heating, leading to an increase in low-level convergence triggering rapid intensification (RI). The strengthening of the relative vorticity tendency terms was due to vertical stretching (TC Fani) and middle tropospheric advection (TCs Luban and Ockhi). The increase or decrease in upper-tropospheric divergence led to RI through two different mechanisms. The increase in upper divergence strengthens the vortical convection (in TC Luban and Fani) by enhancing the moisture and heat transport, whereas its decrease caused a reduction in the upper-level ventilation flow at 200 hPa followed by moisture accumulation, enhanced diabatic heating, and strengthened the warm core (TC Ockhi). The RI caused the vortex of three cyclones to extend up to the upper troposphere. The well organised wind during RI led the unorganised, weak, discontinuous vertical vortex columns to become organised with intense vertical velocity throughout the column. Spatial distributions of Okubo–Wiess (OW) parameter showed TC core dominated by vorticity than strain, since deep depression (DD) stages