Role of Sthanic Chikitsa in Stree Roga: An Ayurveda Review

Ayurveda put health of women on prime focus and gives detailed description on Stree Roga and their management through Ayurveda approaches. The common gynecological problems are Yonidaha, Yonikandu, Yoni paicchilya, Yoni strava, Yoni karkashata, Vamini and Upapluta yonivyapad, etc. The disturbed pattern of menstruation also causes many gynecological problems associated with female health. Ayurveda explains many ways for curing gynecological disorders especially Yoni Roga requiring local therapeutic measures, Sthanik Chikitsa is one of them which offers therapeutic relieves in various Stree Roga. Yoni-Pichu, Yoni Dhoopan, Yonidhawan, Yoni-Lepana, Uttarbasti, Yoni-Varti and Agnikarma, etc. are common approaches of Sthanik Chikitsa which are useful in many gynecological problems. These all approaches of Ayurveda help to maintain good health status of women and relives symptoms of white discharge, itching, burning micturation, foul smell and discharge, etc. These non-surgical and less invasive techniques offers health benefits to retain reproductive health of female and does not imparts severe side effects. Present article explains role of Sthanic Chikitsa in various Stree Roga

A prospective study on postmenopausal bleeding-causes and its diagnosis using transvaginal ultrasound and hysteroscopy

Background: Postmenopausal bleeding (PMB) is considered a red flag symptom and warrants further examination and evaluation. Trans-vaginalsonography (TVS) can be used reliably to diagnose fibroids, polyps and thickened endometrium. Hysteroscopy is considered “gold standard” for evaluating endometrial cavity. It provides direct visualization of endometrial cavity. It can have both diagnostic as well as operative purpose however, it is not cost effective, an invasive procedure and requires anesthesia and expertise. Present study was designed and carried out to study aetiology and prevalence of PMB in Central India as well as to evaluate the efficacy of TVS and hysteroscopy in diagnosis of different endometrial pathologies in patients with PMB.Methods: This prospective study included 82 post-menopausal women with PMB who attended the gynaecological clinic from December, 2019 to December, 2020 at Motherhood hospital, Indore, India after ethical clearance. A detailed history, examination followed by transvaginal sonography was made. Hysteroscopy was then performed, and biopsy was obtained in all patients. Hysteroscopic and sonographic images were then analyzed and conformed with the histopathologic diagnosis.Results: Most common endometrial pathology was atrophic endometrium followed by endometrial polyp and hyperplasia. Endometrial carcinoma was observed in (3.66%) females. Other findings in cases of secretory, proliferative endometrium and endometritis accounted for 6.09%. The diagnostic accuracy of ET by TVS at a cut-off point of 5 mm was 94% with sensitivity 89.3%, specificity 100%, PPV 100% and NPV 88%. The diagnostic accuracy of hysteroscopy was 98% with sensitivity 96.4%, specificity 100%, PPV 100% and NPV 95.7%.Conclusions: TVS with ET measurement should first line investigation in the evaluation of women with PMB with suspected endometrial pathology because of cost effectiveness, easy accessibility and non-invasive method of diagnosis. Although hysteroscopy is more specific and sensitive, in poor resource settings it should be limited to cases with illdefined endometrial lining, recurrent/ persistent bleeding and cases with endometrial thickness greater than 5 mm irrespective of endometrial echotexture

First trimester fetal heart rate as a predictor of newborn sex

OBJECTIVE: To predict the sex of newborns using first trimester fetal heart rate (FHR). METHODS: This was a retrospective review of medical records and ultrasounds performed between 8 and 13 weeks of gestation. Continuous variables were compared using Student\u27s t-tests while categorical variables were compared using Chi-square test. RESULTS: We found no significant differences between 332 (50.7%) female and 323 (49.3%) male FHRs during the first trimester. The mean FHR for female fetuses was 167.0 +/- 9.1 bpm and for male fetuses 167.3 +/- 10.1 bpm (p = 0.62). There was no significant difference in crown rump length between female and male fetuses (4.01 +/- 1.7 versus 3.98 +/- 1.7 cm; p = 0.78) or in gestational age at birth (38.01 +/- 2.1 versus 38.08 +/- 2.1 weeks; p = 0.67). The males were significantly heavier than females (3305.3 +/- 568.3 versus 3127.5 +/- 579.8 g; p \u3c 0.0001) but there were no differences in the proportion of small for gestational age (SGA), average for gestational age (AGA) and large for gestational age (LGA) infants. CONCLUSIONS: We found no significant difference between the female and male FHR during the first trimester in contrast to the prevailing lay view of females having a faster FHR. The only statistically significant difference was that males weighed more than female newborns

On the stability of the conduction regime of natural convection in a vertical slot

The stability of the conduction regime of natural convection in a vertical slot has been studied analytically. For Pr Pr > 12.7 the instability sets in as a travelling wave. As the Prandtl number is increased the onset of instability approaches the correct limiting solution which is constant as a function of GrPr1/2.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33827/1/0000084.pd

Engineering design of a radiative divertor for DIII-D

A new divertor configuration is being developed for the DIII-D tokamak. This divertor will operate in the radiative mode. Experiments and modeling form the basis for the new design. The Radiative Divertor reduces the heat flux on the divertor plates by dispersing the power with radiation in the divertor region. In addition, the Radiative Divertor structure will allow density control in plasma shapes required for advanced tokamak operation. The divertor structure allows for operation in either double-null or single-null plasma configurations. Four independently controlled divertor cryopumps will enable pumping at either the inboard (upper and lower) or the outboard (upper and lower) divertor plates. An upgrade to the DIII-D cryogenic system is part of this project. The increased capabilities of the cryogenic system will allow delivery of liquid helium and nitrogen to the three new cryopumps. The Radiative Divertor design is very flexible, and will allow physics studies of the effects of slot width and length. Radiative Divertor diagnostics are being designed in parallel to provide comprehensive measurements for diagnosing the divertor. The Radiative divertor installation is scheduled for late 1996. Engineering experience gained in the DIII-D Advanced Divertor program form a foundation for the design work on the Radiative Divertor

The DIII-D Radiative Divertor Project: Status and plans

New divertor hardware is being designed and fabricated for the Radiative Divertor modification of the DIII-D tokamak. The installation of the hardware has been separated into two phases, the first phase starting in October of 1996 and the second and final phase, in 1998. The phased approach enables the continuation of the divertor characterization research in the lower divertor while providing pumping for density control in high triangularity, single- or double-null advanced tokamak discharges. When completed, the Radiative Divertor Project hardware will provide pumping at all four strike points of a double-null, high triangularity discharge and provide baffling of the neutral particles from transport back to the core plasma. By puffing neutral gas into the divertor region, a reduction in the heat flux on the target plates will be be demonstrated without a large rise in core density. This reduction in heat flux is accomplished by dispersing the power with radiation in the divertor region. Experiments and modeling have formed the basis for the new design. The capability of the DIII-D cryogenic system is being upgraded as part of this project. The increased capability of the cryogenic system will allow delivery of liquid helium and nitrogen to three new cryopumps. Physics studies on the effects of slot width and length can be accomplished easily with the design of the Radiative Divertor. The slot width can be varied by installing graphite tiles of different geometry. The change in slot length, the distance from the X-point to the target plate, requires relocating the structure vertically and can be completed in about 6-8 weeks. Radiative Divertor diagnostics are being designed to provide comprehensive measurements for diagnosing the divertor. Required diagnostic modifications will be minimal for Phase 1, but extensive for Phase 2 installation. These Phase 2 diagnostics will be required to fully diagnose the high triangularity discharges in the divertor slots

Construction and Characterization of E3-Deleted Bovine Adenovirus Type 3 Expressing Full-Length and Truncated Form of Bovine Herpesvirus Type 1 Glycoprotein gD

AbstractUsing the homologous recombination machinery ofE. coli,a 1.245-kb deletion was introduced in the E3 region of bovine adenovirus 3 (BAV3) genomic DNA cloned in a plasmid. Transfection of the restriction enzyme-excised, linear E3-deleted BAV3 genomic DNA into primary fetal bovine retina cells produced infectious virus (BAV3.E3d), suggesting that all the E3-specific open reading frames are nonessential for virus replicationin vitro. Using a similar approach, we constructed replication-competent (BAV3.E3gD and BAV3.E3gDt) BAV3 recombinant expressing full-length (gD) or truncated (gDt) glycoprotein of bovine herpes virus 1. Recombinant gD and gDt proteins expressed by BAV3.E3gD and BAV3.E3gDt, respectively, were recognized by gD-specific monoclonal antibodies directed against conformational epitopes, suggesting that antigenicity of recombinant gD and gDt was similar to that of the native gD expressed in bovine herpes virus 1-infected cells. Intranasal immunization of cotton rats induced strong gD- and BAV3-specific IgA and IgG immune responses. These results suggest that replication-competent bovine adenovirus 3-based vectors have potential for the delivery of vaccine antigens to the mucosal surfaces of animals

Melatonin protects against alterations in hippocampal cholinergic system, trace metals and oxidative stress induced by gestational and lactational exposure to cadmium

Dietary exposure to cadmium, even at lower doses, can lead to free radical induced neurotoxicity, neurobehavioral changes and alteration in neurotransmitters. Such changes are likely to be more pronounced in the developing brain due to incompleteness of blood brain barrier (BBB). Hippocampus being the seat of intelligence has a role in learning and cognitive behavior and any damage to hippocampus during developmental stage is likely to result in neurodegenerative changes in later life. To this end, fetal and neonatal exposure to cadmium was induced by exposing pregnant dams of Swiss albino strain throughout the period of gestation and following parturition up till 5th day post partum (pp) through drinking water (3ppm/animal/day). The neonates were sacrificed on day 6 pp and indices of oxidative stress, levels of trace elements and changes in cholinergic system were evaluated in the hippocampus. Increased lipid peroxidation, surge in reactive oxygen species (ROS), depressed antioxidant defense, increased accumulation of cadmium, differential alterations in trace elements and decreased activity of AChE were the features of cadmium toxicity. Simultaneous administration of melatonin to cadmium challenged animals offset these detrimental changes. The results suggest that melatonin co-administration can effectively protect against the adverse effects of cadmium on endogenous antioxidant status, changes in trace metal concentrations and compromised hippocampal cholinergic system

DESIGN, FABRICATION, INSTALLATION, TESTING AND INITIAL RESULTS OF IN-VESSEL CONTROL COILS FOR DIII-D

OAK-B135 Since 1995, DIII-D has performed correction of magnetic field imperfections using a set of six external picture frame coils located on the vessel mid-plane. In 2000, these coils also demonstrated benefits when used for feedback of the resistive wall mode, an instability that limits the plasma performance at high beta. Modeling has shown that substantial performance improvements could be achieved by installing new coils inside the vessel and expanding the poloidal coverage above and below the mid-plane. Two prototype internal coils were installed in 2001 and were power tested successfully after several bakes to 350 C. A full set of twelve internal coils and related magnetic sensors are now operational in the DIII-D tokamak. The design requirements for the new coil system was to maximize the magnetic field at the plasma edge, operate with a frequency range of dc to 1000 Hz, and fit behind the existing graphite wall tiles. The coil design adopted and installed is a water-cooled hollow copper conductor insulated with polyamide and housed inside a stainless steel tube that forms a vacuum boundary. The coil is rigidly mounted to the inside of the vacuum vessel. The primary challenge in the design of these coils wa sin joining of both the copper conductor and the stainless tube without overheating the polyamide insulator. Elastic-plastic analysis was used to demonstrate acceptable thermal stresses during baking conditions. Analysis determined the optimum water cooling channel diameter. The coils were tested in high toroidal field to the limit of the power supply of 4.5 kA DC with inductance-limited current for frequencies between 300 Hz and 1000 Hz. Recent results are presented