5,603 research outputs found
Torsion and Nonmetricity in Scalar-Tensor Theories of Gravity
We show that the gravitational field equations derived from an action
composed of i) an arbitrary function of the scalar curvature and other scalar
fields plus ii) connection-independent kinetic and source terms, are identical
whether one chooses nonmetricity to vanish and have non-zero torsion or vice
versa.Comment: 10 page
High Temperature Partition Function of the Rigid String
We find that the high temperature limit of the free energy per unit length
for the rigid string agrees dimensionally with that of the QCD string (unlike
the Nambu-Goto string). The sign, and in fact the phase, do not agree. While
this may be a clue to a string theory of QCD, we note that the problem of the
fourth derivative action makes it impossible for the rigid string to be a
correct description.Comment: 7 page
Proteomic analysis of Bifidobacterium longum subsp. infantis reveals the metabolic insight on consumption of prebiotics and host glycans.
Bifidobacterium longum subsp. infantis is a common member of the intestinal microbiota in breast-fed infants and capable of metabolizing human milk oligosaccharides (HMO). To investigate the bacterial response to different prebiotics, we analyzed both cell wall associated and whole cell proteins in B. infantis. Proteins were identified by LC-MS/MS followed by comparative proteomics to deduce the protein localization within the cell. Enzymes involved in the metabolism of lactose, glucose, galactooligosaccharides, fructooligosaccharides and HMO were constitutively expressed exhibiting less than two-fold change regardless of the sugar used. In contrast, enzymes in N-Acetylglucosamine and sucrose catabolism were induced by HMO and fructans, respectively. Galactose-metabolizing enzymes phosphoglucomutase, UDP-glucose 4-epimerase and UTP glucose-1-P uridylytransferase were expressed constitutively, while galactokinase and galactose-1-phosphate uridylyltransferase, increased their expression three fold when HMO and lactose were used as substrates for cell growth. Cell wall-associated proteomics also revealed ATP-dependent sugar transport systems associated with consumption of different prebiotics. In addition, the expression of 16 glycosyl hydrolases revealed the complete metabolic route for each substrate. Mucin, which possesses O-glycans that are structurally similar to HMO did not induced the expression of transport proteins, hydrolysis or sugar metabolic pathway indicating B. infantis do not utilize these glycoconjugates
The impact of freeze-drying infant fecal samples on measures of their bacterial community profiles and milk-derived oligosaccharide content.
Infant fecal samples are commonly studied to investigate the impacts of breastfeeding on the development of the microbiota and subsequent health effects. Comparisons of infants living in different geographic regions and environmental contexts are needed to aid our understanding of evolutionarily-selected milk adaptations. However, the preservation of fecal samples from individuals in remote locales until they can be processed can be a challenge. Freeze-drying (lyophilization) offers a cost-effective way to preserve some biological samples for transport and analysis at a later date. Currently, it is unknown what, if any, biases are introduced into various analyses by the freeze-drying process. Here, we investigated how freeze-drying affected analysis of two relevant and intertwined aspects of infant fecal samples, marker gene amplicon sequencing of the bacterial community and the fecal oligosaccharide profile (undigested human milk oligosaccharides). No differences were discovered between the fecal oligosaccharide profiles of wet and freeze-dried samples. The marker gene sequencing data showed an increase in proportional representation of Bacteriodes and a decrease in detection of bifidobacteria and members of class Bacilli after freeze-drying. This sample treatment bias may possibly be related to the cell morphology of these different taxa (Gram status). However, these effects did not overwhelm the natural variation among individuals, as the community data still strongly grouped by subject and not by freeze-drying status. We also found that compensating for sample concentration during freeze-drying, while not necessary, was also not detrimental. Freeze-drying may therefore be an acceptable method of sample preservation and mass reduction for some studies of microbial ecology and milk glycan analysis
Book Reviews
Law-Making in the International Civil Aviation Organization By Thomas Buergenthal Syracuse University Press, 1969. Pp. viii,247. 7.50.
reviewer: Nat. T. Winston, Jr., M.D.
====================================
The Development of Political Attitudes in Children By Robert D. Hess & Judith V. Torney Chicago: Aldine Publishing Co., 1967. Pp. xviii, 288. $9.75.
reviewer: Dan B. Germa
Air-to-Water Heat Pumps With Radiant Delivery in Low-Load Homes
Space conditioning represents nearly 50% of average residential household energy consumption, highlighting the need to identify alternative cost-effective, energy-efficient cooling and heating strategies. As homes are better built, there is an increasing need for strategies that are particularly well suited for high performance, low load homes. ARBI researchers worked with two test homes in hot-dry climates to evaluate the in-situ performance of air-to-water heat pump (AWHP) systems, an energy efficient space conditioning solution designed to cost-effectively provide comfort in homes with efficient, safe, and durable operation. Two monitoring projects of test houses in hot-dry climates were initiated in 2010 to test this system. Both systems were fully instrumented and have been monitored over one year to capture complete performance data over the cooling and heating seasons. Results are used to quantify energy savings, cost-effectiveness, and system performance using different operating modes and strategies. A calibrated TRNSYS model was developed and used to evaluate performance in various climate regions. This strategy is most effective in tight, insulated homes with high levels of thermal mass (i.e. exposed slab floors)
Parameterized Model-Checking for Timed-Systems with Conjunctive Guards (Extended Version)
In this work we extend the Emerson and Kahlon's cutoff theorems for process
skeletons with conjunctive guards to Parameterized Networks of Timed Automata,
i.e. systems obtained by an \emph{apriori} unknown number of Timed Automata
instantiated from a finite set of Timed Automata templates.
In this way we aim at giving a tool to universally verify software systems
where an unknown number of software components (i.e. processes) interact with
continuous time temporal constraints. It is often the case, indeed, that
distributed algorithms show an heterogeneous nature, combining dynamic aspects
with real-time aspects. In the paper we will also show how to model check a
protocol that uses special variables storing identifiers of the participating
processes (i.e. PIDs) in Timed Automata with conjunctive guards. This is
non-trivial, since solutions to the parameterized verification problem often
relies on the processes to be symmetric, i.e. indistinguishable. On the other
side, many popular distributed algorithms make use of PIDs and thus cannot
directly apply those solutions
- …