Postpartum depression and thyroid dysfunction– should pregnant women be screened for thyroid disorders?

The relationship between thyroid dysfunction and postpartum depression has been investigated for quite some time now, but no consensus has been reached regarding the need for screening for thyroid function during pregnancy. This paper aims to investigate whether thyroid hormone screening in pregnancy might contribute to the diagnosis of postpartum depression. Depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS) - one of the most widely used measures in detecting postpartum depression and anxiety. Thyroid function was measured using the commonly recommended thyroid laboratory tests. A structured questionnaire was given to 61 patients closely monitored during their pregnancy and at least one year after giving birth, including for thyroid and depression disorders. The questionnaire was completed anonymously online by the patients and had three sections: one containing the EPDS questions, one assessing thyroid function, and a demographic section. The interdependency between thyroid and depression was analyzed in SPSS using the Pearson chi-square test of independence. The results show no statistically significant relationship between thyroid dysfunction and depression. In other words, women suffering from thyroid dysfunctions have no greater rate of depression compared to women without thyroid dysfunction. As a result, it screening for thyroid disorders during pregnancy may not provide relevant information for detecting postnatal depression

Understanding how entrepreneurship education influences students’ entrepreneurial learning outcomes, studying the case of the entrepreneurship education minor at the University of Oulu, Finland

Abstract. Entrepreneurship education and students’ entrepreneurial learning outcomes are at the core of this thesis. This research aims to understand how a global phenomenon such as entrepreneurship education influences students’ entrepreneurial learning outcomes, studying the case of the entrepreneurship education minor at the University of Oulu. The theoretical background is built around entrepreneurship education and entrepreneurial learning outcomes, to provide the reader with an overview of the two concepts. The theoretical framework expands on the concept of entrepreneurial learning outcomes, with the help of two theories: the Tripartite Competence Framework and the European Competence Framework (EntreComp Model). The methodology used in this research is a single intrinsic explanatory case study. Case study research was used with the goal to understand, explain, and then assess the impact of the entrepreneurship education program on students’ entrepreneurial learning outcomes. The empirical part of the research focuses on four sources of data: interviews with seven students, interviews with two professors, internal documents and students’ course feedback. All four data sources were analyzed using content analysis, by coding the data and generating subcategories and categories. The findings of the data analysis showcased that by taking the entrepreneurship education minor at the University of Oulu, students have gained different entrepreneurial learning outcomes, such as entrepreneurship knowledge, skills, mindset and attitude. The research findings prove to be important in the following aspects. First, even though this study is bounded given the specific context, it demonstrates the importance of entrepreneurship in the education field and encourages higher education institutions in Finland to integrate entrepreneurship education courses in their interdisciplinary curricula. Second, entrepreneurship education programs can influence students’ intentions towards becoming future entrepreneurs. Lastly, it emphasizes the importance of entrepreneurial learning outcomes as transferable skills that are not limited to the field of entrepreneurship, but can be useful in other contexts as well

A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma

Aims: CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC) but neither this sensitivity nor specificity is absolute. This study is the first known comparison of CDX1 and A33 against CDX2 as immunomarkers for CRC. Methods and Results: As a pilot study, whole sections of 51 cases of liver metastatic carcinoma of different origins - colorectum (n=32), breast (n=3), oesophagogastric tract (n=4), lung (n=3), pancreas (n=8), and prostate (n=1) - were immunostained with CDX1, CDX2 and A33. Compared with CDX1, A33 showed higher sensitivity as a CRC immunomarker, greater interobserver reproducibility for assessment of expression, and less background cross-reactivity. Therefore, only A33 was compared with CDX2 for a tissue microarray-based study of primary adenocarcinomas of different origin: CRC (n=55), liver deposits of metastatic CRC (n=60), breast (n=101), lung (n=40), oesophagogastric tract (n=134), ovary (n= 67), pancreas (n= 77), and prostate (n= 56). Combining the whole section and TMA cases of CRC, A33 had a sensitivity of 95.9% and CDX2 a sensitivity of 97.2%. Combining all the whole section and TMA cases of non-colorectal carcinomas, A33 showed 85.4% specificity as a marker of CRC compared to CDX2 which showed a specificity of 64.3%. The higher specificity of A33 as a colorectal carcinoma immunomarker compared with CDX2 was particularly seen amongst pancreatic and ovarian carcinomas. Further, unlike with CDX2, none of the prostatic and lung carcinomas studied showed A33 positivity. Conclusions: A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of CRC

Language in a world of plurality:the tree, the bot and the octopus teacher

Abstract. Language has been considered proof of human exceptionalism in the Western European culture since the Enlightenment era. As a result, a rigid hierarchy placing human on the top emerged. Due to human’s capacity to rationalize thought and materialize it using language as a tool, it entitled itself to possess and dispose of anything deemed as less- or non-human. Once the fixed idea of language is destabilized, its accuracy as a tool fit enough to represent the world and human thought comes into question. Once language, a pillar of Humanism, is damaged, the collapse of human exceptionalism is imminent. Post-humanism and ontological pluralism are offering the grounds for exploring a paradigm without the hierarchy. A flattened reality in which the relationships between ways of being are far more complex than mere hierarchies, food chains, or concentric circles. They are entangled, mangled. They are plugging-in and unplugging in an assemblage. For inquiring into an assemblage, tools such as qualitative methodologies, representational logic and data become useless. Meanwhile, post-qualitative inquiries do not pretend to ascend the ultimate, pure knowledge or truth but simply offer a brief, incomplete glimpse into the assemblage. The results of such destabilizations consist of more care and attention being offered to negotiating language and languaging, empty spaces and howls, communication outside the higher senses of sight and hearing. In education, it translates into alternative teachers and teachings. The learners are entangled into an assemblage with which they are inter-acting by forming relationships. They are learning to co-live with rather than to make sense of the ways of being

Dissecting the Power Sources of Low-Luminosity Emission-Line Galaxy Nuclei via Comparison of HST-STIS and Ground-Based Spectra

Using a sample of ~100 nearby line-emitting galaxy nuclei, we have built the currently definitive atlas of spectroscopic measurements of H_alpha and neighboring emission lines at subarcsecond scales. We employ these data in a quantitative comparison of the nebular emission in Hubble Space Telescope (HST) and ground-based apertures, which offer an order-of-magnitude difference in contrast, and provide new statistical constraints on the degree to which Transition Objects and low-ionization nuclear emission-line regions (LINERs) are powered by an accreting black hole at <10 pc. We show that while the small-aperture observations clearly resolve the nebular emission, the aperture dependence in the line ratios is generally weak, and this can be explained by gradients in the density of the line-emitting gas: the higher densities in the more nuclear regions potentially flatten the excitation gradients, suppressing the forbidden emission. The Transition Objects show a threefold increase in the incidence of broad H_alpha emission in the high-resolution data, as well as the strongest density gradients, supporting the composite model for these systems as accreting sources surrounded by star-forming activity. The narrow-line LINERs appear to be the weaker counterparts of the Type 1 LINERs, where the low accretion rates cause the disappearance of the broad-line component. The enhanced sensitivity of the HST observations reveals a 30% increase in the incidence of accretion-powered systems at z~0. A comparison of the strength of the broad-line emission detected at different epochs implies potential broad-line variability on a decade-long timescale, with at least a factor of three in amplitude.Comment: 27 pages, 13 figures, 4 tables, accepted for publication in Ap