Idealised simulations of cyclones with robust symmetrically-unstable sting jets

Idealised simulations of Shapiro-Keyser cyclones developing a sting jet (SJ) are presented. Thanks to an improved and accurate implementation of thermal wind balance in the initial state, it has been possible to use more realistic environments than in previous idealised studies. As a consequence, this study provides further insight in SJ evolution and dynamics and explores SJ robustness to different environmental conditions, assessed via a wide range of sensitivity experiments. The control simulation contains a cyclone that fits the Shapiro-Keyser conceptual model and develops a SJ whose dynamics are associated with the evolution of mesoscale instabilities along the airstream, including symmetric instability (SI). The SJ undergoes a strong descent while leaving the cloud-head banded tip and markedly accelerating towards the frontal-fracture region, revealed as an area of buckling of the already-sloped moist isentropes. Dry instabilities, generated by vorticity tilting via slantwise frontal motions in the cloud head, exist in similar proportions to moist instabilities at the start of the SJ descent and are then released along the SJ. The observed evolution supports the role of SI in the airstream’s dynamics proposed in a conceptual model outlined in a previous study. Sensitivity experiments illustrate that the SJ is a robust feature of intense Shapiro-Keyser cyclones, highlighting a range of different environmental conditions in which SI contributes to the evolution of this airstream, conditional on the model having adequate resolution. The results reveal that several environmental factors can modulate the strength of the SJ. However, a positive relationship between the strength of the SJ, both in terms of peak speed and amount of descent, and the amount of instability occurring along it can still be identified. In summary, the idealised simulations presented in this study show the robustness of SJ occurrence in intense Shapiro-Keyser cyclones and support and clarify the role of dry instabilities in SJ dynamics

Louis XVI’s Chapel during the French Revolution 1789-1792

Abstract — The close association of Christianity with the late Bourbon monarchy’s style of governance has often been interpreted as a burdensome legacy, which impacted greatly on the period preceding the French Revolution. In recent years, historians have referred to the ideological, juridical and intellectual assaults on the religious foundations of the French crown, throughout the eighteenth century, either as a process of ‘ desacralization ’ or as the religious origins of the French Revolution. This article, though inspired by this school of thought, takes a different approach by examining the less well-known ceremonial and ritual components of this form of kingship, with particular reference to the king’s chapel. Louis XVI’s ecclesiastical household was both the centre of royal patronage for the Gallican Church and the chief regulatory authority of the monarch’s personal religious devotion. Its actions, transformation and fate during the Revolution are instructive in two ways. First, its survival during the first three years of the revolutionary troubles highlights its fundamental and constraining influence over the French monarchy. Secondly, the gradual, though determined, effort to undermine the pact between throne and altar that it represented exemplifi es a lesser known aspect of the national deputies ’ anticlerical agenda

Esperimento RTK1: verifica delle prestazioni del posizionamento NRTK (Cap. 4 app. 1)

Un libro bianco su: "I servizi di posizionamento satellitare per l'e-government

Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women

9Objective: To test the immunohistochemical staining pattern of some mismatch repair (MMR) system proteins in endometriotic tissue (ET) and eutopic endometrium. Methods: This was a retrospective study conducted at the Pathology and Obstetrics and Gynecology Departments of the Udine University Hospital. We analyzed 528 samples obtained from 246 patients affected by endometriosis and 71 samples from 71 patients with normal endometrium. A tissue microarray model was used to analyze the immunohistochemical expression of MMR system proteins. Results: Significant loss of MMR proteins was found in the stromal component of ETs. We found MSH2 to be expressed at a higher level than any other MMR system proteins in eutopic endometrium and ETs, to be significantly correlated to Ki-67 expression in both stromal and glandular components of ETs, and to be expressed at a significantly higher level in ETs than in eutopic endometrium. When considering the subgroup of endometriosis with high recurrence rate and glandular cytoplasmic staining for aurora A kinase, we found MMR proteins expressed at a significantly higher level in these ETs than in other ETs and eutopic endometrium of unaffected women. Conclusions: We found significant loss of MMR proteins (known to be associated with microsatellite instability) in the stromal component of ETs. The group of ETs with glandular cytoplasmic staining for aurora A kinase had higher MMR protein expression, suggesting an increased activity of this system. Our result suggests a novel role of increased MSH2 expression in cellular proliferation of endometriosis.openopenGrassi, T.; Calcagno, A.; Marzinotto, S.; Londero, A.P.; Orsaria, M.; Canciani, G.N.; Beltrami, C.A.; Marchesoni, D.; Mariuzzi, L.Grassi, T.; Calcagno, A.; Marzinotto, S.; Londero, Ambrogio P.; Orsaria, M.; Canciani, G. N.; Beltrami, Carlo Alberto; Marchesoni, Diego; Mariuzzi, Laur

Louis XVI and Marie Antoinette

The important role played by Louis XVI and Marie Antoinette in the radicalization of the early phase of the French Revolution has never been in doubt. Most histories continue to focus on the regal couple’s real, and supposed, role in fomenting counter-revolution at home and especially abroad. This chapter engages with the complex question of the dwindling fortunes of Louis XVI’s monarchy from a more domestic angle. It focuses on that neglected, though crucial, year of 1790 which witnessed the failure to erect a viable constitutional settlement. It became impossible to accommodate both Crown and assembly in a viable working relationship. Essentially, the king’s distrust for the deputies, who had little by little arrogated his remaining powers, proved insurmountable. The monarchy’s passive resistance to the revolution’s early reform programme and political culture became increasingly unpopular. This created a radicalized and tension-filled atmosphere which pushed the revolution into hitherto unexpected directions