Teologi Pembebasan Asia

Judul Asli: life in freedom liberation teologies from Asiaxvi, 333 p.; 21c

Denovo generated human red blood cells in humanized mice support Plasmodium falciparum infection

10.1371/journal.pone.0129825PLoS ONE106e012982

Integrated analysis of the Plasmodium species transcriptome

The genome sequence available for different Plasmodium species is a valuable resource for understanding malaria parasite biology. However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. Here, we developed a comprehensive approach to measure transcriptional changes of the evolutionary conserved syntenic orthologs during the intraerythrocytic developmental cycle across six Plasmodium species. We show significant transcriptional constraint at the mid-developmental stage of Plasmodium species while the earliest stages of parasite development display the greatest transcriptional variation associated with critical functional processes. Modeling of the evolutionary relationship based on changes in transcriptional profile reveal a phylogeny pattern of the Plasmodium species that strictly follows its mammalian hosts. In addition, the work shows that transcriptional conserved orthologs represent potential future targets for anti-malaria intervention as they would be expected to carry out key essential functions within the parasites. This work provides an integrated analysis of orthologous transcriptome, which aims to provide insights into the Plasmodium evolution thereby establishing a framework to explore complex pathways and drug discovery in Plasmodium species with broad host range

Globally responsible leadership: When east meets west: an investigation of challenges and drivers of successful implementation of CSR in five companies

Using qualitative data collected from interviews and focus groups of senior leaders from five global companies operating in Europe, Asia, South America and Africa, this study makes two important contributions to the theory of globally responsible leadership. First, it depicts a framework of catalysts and drivers for sustainability for use by responsible leaders. Second, it develops a framework of globally responsible leadership that covers eight components of responsible leadership. These frameworks will benefit both scholars and practitioners in the fields of leadership and sustainability