Gait Mechanics are Influenced by Quadriceps Strength, Age, and Sex after Total Knee Arthroplasty

Although most patients are satisfied with outcomes after total knee arthroplasty (TKA), many retain preoperative altered gait mechanics. Identifying patient characteristics associated with gait mechanics will improve rehabilitation strategies and enhance our understanding of movement disorders. Therefore, the purpose of this study was to identify which patient characteristics are related to gait mechanics in the surgical limb during walking post-TKA. Patient characteristics included age, body mass, sex, quadriceps strength, self-reported function, and knee pain. General linear regression was used to compare patient characteristics associated with gait mechanics, after controlling for gait speed, functional capacity and time from surgery. We tested 191 patients cross-sectionally at 6–24 months after primary, unilateral TKA. Quadriceps weakness in the surgical limb was associated with less peak vertical ground reaction force (PvGRF) (β = .245, p = .044), knee extension moment (β = .283, p = .049), and knee extension excursion (β = .298, p = .038). Older age (β = .168, p = .050) was associated with less PvGRF. Quadriceps strength in the nonsurgical limb (β = −.357, p = .021) was associated with greater knee extension excursion in the surgical limb. Females with TKA (β = −.276, p = .007) had less knee flexion excursion compared to males. Faster gait speed was also associated with greater PvGRF (β = .585, p \u3c .001), knee extensor moment (β = .481, p \u3c .001), and knee flexion excursion (β = .318, p \u3c .001). Statement of Clinical Significance: This study showed quadriceps weakness, slower gait speed, older age and being female were related to altered gait mechanics post-TKA. These findings will help clinicians better educate patients and develop targeted interventions for improving care in patients post-TKA

Undifferentiated HepaRG cells show reduced sensitivity to the toxic effects of M8OI through a combination of CYP3A7-mediated oxidation and a reduced reliance on mitochondrial function

\ua9 2024 The AuthorsThe methylimidazolium ionic liquid M8OI (1-octyl-3-methylimidazolium chloride, also known as [C8mim]Cl) has been detected in the environment and may represent a hazard trigger for the autoimmune liver disease primary biliary cholangitis, based in part on studies using a rat liver progenitor cell. The effect of M8OI on an equivalent human liver progenitor (undifferentiated HepaRG cells; u-HepaRG) was therefore examined. u-HepaRG cells were less sensitive (>20-fold) to the toxic effects of M8OI. The relative insensitivity of u-HepaRG cells to M8OI was in part, associated with a detoxification by monooxygenation via CYP3A7 followed by further oxidation to a carboxylic acid. Expression of CYP3A7 - in contrast to the related adult hepatic CYP3A4 and CYP3A5 forms - was confirmed in u-HepaRG cells. However, blocking M8OI metabolism with ketoconazole only partly sensitized u-HepaRG cells. Despite similar proliferation rates, u-HepaRG cells consumed around 75% less oxygen than B-13 cells, reflective of reduced dependence on mitochondrial activity (Crabtree effect). Replacing glucose with galactose, resulted in an increase in u-HepaRG cell sensitivity to M8OI, near similar to that seen in B-13 cells. u-HepaRG cells therefore show reduced sensitivity to the toxic effects of M8OI through a combination of metabolic detoxification and their reduced reliance on mitochondrial function

The Role of the Scientific Endowment in Achieving the Sustainable Development Goals of the United Nations

The researcher aimed by this scientific paper to try to define the role played by a number of Universal and Saudi university endowments in achieving the sustainable development goals of the United Nations by identifying the goals and reality of these endowments, with some future proposals to enhance this role played by university endowments in achieving sustainable development goals. In order to achieve the goals of this paper, the Researcher used has used both deductive approach and descriptive approach in the style of documentary studies. The results and future proposals that have been reached to enhance the role that universities endowments can play in achieving sustainable development goals include the following: Since, university endowments are one of the important strategic options for achieving sustainable development goals; then, work shall be done in order to expand the establishment and revitalization of university endowments, and activate its role, as an urgent necessity and not as an option only, to be a tributary to spending on scientific research, scholarships, achievement of scientific and technological progress, and support of projects and industries that lead to sustainable scientific, cultural, social and economic development; that is through professional marketing that attracts relevant parties to establish, support and develop endowments, while spreading the culture of donation, as is the case with the international universities that are leaders and pioneers in the field of their endowments, in addition to caring out awareness educational and cultural campaigns to introduce the university endowment and its importance through schools, universities, mosques "Masjids", and various means of media, and for universities to adopt carrying out awareness cultural and educational campaigns, workshops, lectures, seminars, forums, and conferences that discuss and highlight the role of the university endowment in supporting the building and establishing of the knowledge society in terms of production, employment, exploitation, publishing and dissemination, and its role in achieving sustainable development goals, provided that these awareness cultural and educational campaigns, workshops, lectures, seminars, forums, and conferences to be directed to members of the educational and administrative staff, current students, alumni and graduate students, companies and private institutions, banks, and businessmen, with the aim of supporting and developing endowment assets; this is in order to enhance social responsibility, while raising awareness of the public opinion about the benefits of university endowments in terms of the achievement of sustainable development goals, and for the future of all societies

Preserving Privacy in Association Rule Mining Using Metaheuristic-Based Algorithms: A Systematic Literature Review

The current state of Association Rule Mining (ARM) technology is heading towards a critical yet profitable direction. The ARM process uncovers numerous association rules, determining correlations between itemsets, forming building blocks that have led to revolutionary scientific discoveries. However, a high level of privacy is vital for protecting sensitive rules, raising privacy concerns. Researchers have recently highlighted challenges in the Privacy-Preserving Association Rule Mining (PPARM) field. Many studies have proposed workarounds for the PPARM dilemma by using metaheuristics. This paper conducts a systematic literature review on metaheuristic-based algorithms addressing PPARM challenges. It explores existing studies, providing insights into diverse metaheuristic approaches tackling PPARM problems. A detailed taxonomy is presented, offering a structured classification of metaheuristic-based algorithms specific to PPARM. This classification facilitates a nuanced understanding of the field by categorizing these algorithms into metaphor-based and non-metaphor-based groups, with a discussion of the nature of the representation schemes for each category identified in the survey. The review extends its analysis to encompass the latest applied approaches, highlighting the diversification of existing metaheuristic algorithms in the PPARM context. Moreover, common datasets and evaluation metrics identified from selected studies are documented to provide a deeper understanding of the methodological choices made by researchers in this domain. Finally, a discussion of existing challenges and potential future directions is presented. This review serves as a helpful guide that outlines previous research and presents potential future opportunities for metaheuristic-based algorithms in the context of PPARM

Rare Tumors 2010; volume 2:e11 Primary mediastinal Castleman’s disease

Castleman’s disease is a rare entity with an unknown etiology which was first described by Castleman in 1954. It is a lymphoproliferative disorder histologically classified into three types; hyaline-vascular, plasma cell type and mixed type. It might be localized or multicentric and usually involves the mediastinum. We report a case of Castleman’s disease discovered accidentally in a case of blunt chest trauma which caused a challenging diagnostic process and management. Case Report A 39-year old man presented to the ER with progressive dyspnea and cough for the last si

Hyers-Ulam and Hyers-Ulam-Rassias Stability of First-Order Linear Dynamic Equations

We present several new sufficient conditions for Hyers-Ulam and Hyers-Ulam-Rassias stability of first-order linear dynamic equations for functions defined on a time scale with values in a Banach space

Psychological Resilience, Anxiety, and Well-Being of Health Care Providers During the COVID-19 Pandemic

Amani M AlQarni,1 Abdelaziz Elfaki,2 Moataza M Abdel Wahab,1 Yasser Aljehani,3 Auday A ALKhunaizi,4 Sharifah A Othman,5 Reem A AlShamlan2 1Family and Community Medicine Department, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2Psychiatry Department, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 3Department of Surgery, King Fahd Hospital of the University, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia; 4Emergency Department, Qatif Central Hospital, Qatif, Saudi Arabia; 5Obstetrics and Gynaecology Department, King Fahd Hospital of the University, Dammam, Saudi ArabiaCorrespondence: Reem A AlShamlan; Amani M AlQarni, Tel +966536353448 ; +966591775751, Email [email protected]; [email protected]: On the frontlines of the pandemic, healthcare providers (HCPs) are overworked, anxious, and fearful. Yet, despite all the fear and anxiety, the facilitation of protective resilience and psychological well-being has become crucial to ensure that minimal intangible psychological losses are incurred due to the pandemic.Aim: The present study aimed to examine the psychological resiliency, state anxiety, trait anxiety, and psychological well-being of frontline HCPs during the COVID-19 and to determine the association among resiliency, state-trait anxiety, and psychological well-being and their links with demographic and workplace factors.Design and Settings: A cross-sectional study concerning frontline HCPs was conducted at two of the largest hospitals in the eastern province of Saudi Arabia.Results: A significant inverse correlation was determined between resilience and state anxiety (r=− 0.417, p< 0.05) and between resilience and trait anxiety (r=− 0.536, p< 0.05). Likewise, a positive intermediate correlation between resilience and the age of the individual (r=0.263, p< 0.05) and a weak positive correlation with years of experience (r=0.211, p< 0.05) were established. Also, the resilience score of volunteer workers (50.9) was lower than that of regular staff (66.8) (p=0.028).Conclusion: Resilience is a crucial factor affecting the training of individuals, which will further promote their work output and mental health capacity, thus improving their overall concept of survival in adversity.Keywords: psychological distress, anxiety, resilience, well-being, COVID-19 pandemic, health care provider