Mixed Ligand Complexes of Cobalt (II) Barbitone in Aqueous Medium and their Biological Activities

Complexes of cobalt (II) barbitone and thiocyanate ion mixed ligands have been synthesized and characterized by a direct mixing method on the basis of their solubilities, melting points, elemental analyses as well as the spectroscopic analyses. Biological evaluations of the solid metal complexes and the free ligand were screened against the selected bacteria pathogens viz: Pseudomonas aeruginosa and bacillus subtitis and fungi species which include Sclerotiania trifoliorun, Fusarium oxyporium, Stemania paradoxa and Botrytis cinerea. The results of the metal complexes analyses have revealed that cobalt ions coordinated bidentately with the ligand through the ring carbonyl oxygen and nitrogen atom of the amide group, and also found to be soluble in ethanol and dimethylsulphuroxide and non-electrolytic in nature/character. The biological activities of metal complexes revealed that they were toxic to the selected fungi but not effective as antibacterial agents except in the mixed ligand metal complexes. However, complexes were more potent than the free ligand.   Keywords: Barbitone, mixed ligand, cobalt and biological activities

The Prevalence of Malaria Parasitic Infections in Cord Blood: Association with Some Socio Demographic Profile

This study aimed at investigating the relationship between some selected socio demographic profile and malaria parasitic infections in cord blood. It involved 100 cord blood samples of newly delivered babies at the Irrua Specialist Teaching Hospital, Irrua, Edo State. Samples were subjected to microscopic examinations following standard protocols and the prevalence of malaria parasitic infections in cord blood were identified using thick and thin blood films. Plasmodium species and packed cell volume were identified and determined using rapid antigen techniques and microhaematocrit respectively. Results showed that malaria parasite was present in 9.0% of samples and was higher in babies with weights ≤1.0kg (66.70%) and PCV of 25.50% (15.40%). As regards species distribution, Plasmodium falciparum had the highest prevalence (6%). Based on the methods used, microscopic method had higher prevalence (9%) over rapid detection technique (6%). On the methods used, malaria parasitic infections was also higher among the age 36-40 years (12.5%), primigravidae (15.6%), rural dwellers (16.1%), unskilled labour (22.2%), educational status ≤SSCE (12.5%) and mothers that do not use prophylaxis (45.5%). Overall, the prevalence of malaria parasites in cord blood is low in the studied area, yet the associated consequence of mother-to-child transmission can not be ignored.Keywords: Babies, Cord blood, Demographic profile, Malaria parasites, Relationship

Synthesis, characterization and antimicrobial evaluations of mixed ligand complexes of sulphamethaxole and metronidaxole with some transistion metals (Zn, Co, Cu and Fe) in water methanol medium

Sulfamethoxazole and metronidazole are antibiotics use for the treatment of various bacterial infections. Their use as ligand is very prominent in formation of metal complexes. The transition metal complexes are synthesized by reaction of Sulfamethoxazole and metronidazole with metals such Mn(II), Cu(II), Fe(II) and Ni(II). The synthesized metal complexes are tested as antibacterial and antifungal. The antimicrobial activity of the complexes displays good potency against some microorganism such as Xanthomonas axonopodis, Streptococcus faecalia, Salmonella entrica, Claribacter michiganense, Xanthomonas phaseolin for bacteria and S.roofisii, M.phonoides, C.lindimuthianum for the fungi, it is revealed that all copper complexes show stronger antibacterial activity than the free drugs. The spectroscopic properties of the complexes were investigated using UV/visible and FT-IR which show metal-charge from 3d to 3s transition in which the transition state shows that they are octahedral geometry and their coordination site respectively. Their percentage yield was moderately high and producible. The complexes synthesized have higher inhibitory activities than the free ligand. The drug resistance in microbes is resulting in the incompetence of available drugs to care for the infections. The thermal analysis shows that the complexes are stable