Experimental observation of parametric X-ray radiation directed along the propagation velocity of relativistic electrons in a tungsten crystal

Parametric X-ray radiation (PXR) due to dynamic diffraction of relativistic electrons is experimentally observed at small angles to the propagation velocity of electrons in a tungsten crystal. The specific features of the experimental method are described, and forward PXR reflections from two crystallographic planes of tungsten are reliably measuredyesBelgorod State Universit

Diffraction of real and virtual photons in a pyrolytic graphite crystal as source of intensive quasimonochromatic X-ray beam

A series of experiments on the parametric X-rays radiation (PXR) generation and radiation soft component diffraction of relativistic electrons in pyrolytic graphite (PG) crystals have been carried out at the Tomsk synchrotronyesBelgorod State Universit

Network interaction in the tourist and recreational sphere

This article addresses questions on the formation of network structures in the tourism and recreational sphere because most prospective forms of interaction occur during the creation of a regional tourism product. The importance of networks in the solution of questions on the spatial localization of the tourist offer is noted, network designs in formation of tourism products are considered and the need to create substantially flexible networks for development of tourism that takes into account the available resources and the solution to the solution to the issue of redistribution of tourist stream

The Main Modern Trends in the Economy and Society in the Development of Tourism

Research aimed to reveal the character of the links between main modern trends in the economy and society and the development of tourism as one of the sectors of the Russian economy, on the one hand, and the type of human activity, on the othe

Economic aspects of the cardiology program expansion of additional drugs provision by effective lipidlowering drugs for hypercholesterolemia control

The federal program of preferential drug provision in cardiology shows its effectiveness. However, hypercholesterolemia (HCH) remains a significant problem in patients in whom high-dose statin therapy does not provide the target level of low-density lipoprotein cholesterol (LDL cholesterol). The solution to the problem lies in the plane of prescribing lipid-lowering drugs of a different mechanism of action, for example, inhibitors of the PCSK9 enzyme. To recommend the inclusion of such kind drugs in the program, it is necessary not only to have evidence of their life-saving effect, but also the economic feasibility of their use. Aim: to evaluate the economic efficacy of alirocumab (INN) including in the federal program for patients who have suffered an acute coronary event, are receiving statins and have an LDL CH level of 5.0 mmol/l and higher.Materials and methods. Modeling was applied in a target group of 3029 patients of working age who had undergone ACS during the previous 12 months with severe, including familial, HCH, with LDL cholesterol 5.0 mmol/l and higher, receiving statins taking into account previously determined outcomes when using alirocumab + statins for 5 years. Direct medical and non-medical costs, as well as indirect costs, are identified. The cost-effectiveness analysis was applied from the point of view of the effectiveness of treatment (effects on mortality, temporary disability, disability) and direct health care costs (additional drug provision and outpatient follow-up, specialized, including high-tech, medical care in a 24‑hour hospital). Two healthcare technologies were compared: statin therapy and use of alirocumab + statins. The calculations used according to domestic methods used the cost of medical treatment, temporary disability, hospitalizations, loss of GDP and other parameters.Results. Modeling has shown a decrease in mortality, morbidity and disability when using alirocumab in even the first year of use. The economic effect of alirocumab from a decrease in temporary disability in the 1st year is 304.5 mln rub., in the 2nd — 301.5 mln rub., in the 3rd — 321.1 mln rub., in the 4th — 333.1 mln rub. The estimated amount of prevented GDP losses from mortality in the target group for 4 years in the case of alirocumab use amounted to 1,260.2 mln rub. The annual amount of avoidable GDP losses from mortality in the target group in the case of alirocumab is 27–30 %. The annual average savings per patient in the case of alirocumab use are from 7 to 17 %. The greatest impact on reducing losses from disability and mortality of the target group is noted in the group of people aged 40–59 years. Only for this group, if alirocumab is used, it is possible to reduce losses from disability and mortality by 159.2 million rubles per year (83 % of the total economic effect). Starting from the 4th year of alirocumab use, it is possible to obtain a positive economic effect in terms of hospitalization costs.Conclusion. When alirocumab is included in the program of additional drug provision in cardiology, the share of costs for the purchase of alirocumab for the target group may be only 0.01 %. At the same time, the economic effect of inclusion in the first year alone will amount to at least 393.4 million rubles of budget funds. The total amount of avoidable losses due to the alirocumab usage may amount to 1,638 million rubles over 4 years

Ethnic and religious aspects of gender behavior and reproductive directions of young adult females living in Transbaikal region: a 10-year trend

The design of the research: two cross-sectional cohort studies with 10-year interval. The study included young adult females, 18-25 years of age: 209 women from Buryat population (in 2005 - 100, in 2015 - 109 persons) and 207 women from Russian population (in 2005 - 100, in 2015 -107 females). We found some positive trends in reproductive paradigm and gender behavior: relatively stable age of sexual debut, increasing role of health workers in young people reproductive education, a change of orientation in reproductive paradigm towards the model of multiple children family. The number of Orthodox believers significantly increased in Russian subpopulation

MODERN EPIDEMIOLOGY OF VECTOR-BORNE TICK-BORNE INFECTIONS IN NORTHERN DISTRICTS OF THE IRKUTSK REGION

Проведен вирусолого-микробиологический мониторинг семи северных районов Иркутской области. Полученные в ходе исследования данные свидетельствуют об изменении эпидемиологической ситуации в отношении клещевых инфекций на территории данных районов. Отмечается продвижение природных очагов на север. На территории северных районов выявлены сочетанные очаги, клещевых инфекций, в том числе обнаружена циркуляция новых для Восточной Сибири патогенов - E. muris, A. phagocytophilum, B. miyamotoi

Spatially Ordered Matrix of Nanostructured Tin–Tungsten Oxides Nanocomposites Formed by Ionic Layer Deposition for Gas Sensing

The process of layer-by-layer ionic deposition of tin-tungsten oxide films on smooth silicon substrates and nanoporous anodic alumina matrices has been studied. To achieve the film deposition, solutions containing cationic SnF2 or SnCl2 and anionic Na2WO4 or (NH4)2O·WO3 precursors have been used. The effect of the solution compositions on the films deposition rates, morphology, composition, and properties was investigated. Possible mechanisms of tin-tungsten oxide films deposition into the pores and on the surface of anodic alumina are discussed. The electro-physical and gas-sensitive properties of nanostructured SnxWyOz films have been investigated. The prepared nanocomposites exhibit stable semiconductor properties characterized by high resistance and low temperature coefficient of electrical resistance of about 1.6 × 10 −3 K −1. The sensitivity of the SnxWyOz films to 2 and 10 ppm concentrations of ammonia at 523 K was 0.35 and 1.17, respectively. At concentrations of 1 and 2 ppm of nitrogen dioxide, the sensitivity was 0.48 and 1.4, respectively, at a temperature of 473 K. At the temperature of 573 K, the sensitivity of 1.3 was obtained for 100 ppm of ethanol. The prepared nanostructured tin-tungsten oxide films showed promising gas-sensitivity, which makes them a good candidate for the manufacturing of gas sensors with high sensitivity and low power consumption