1 research outputs found
Synthesis of Urea Derivatives in Two Sequential Continuous-Flow Reactors
A continuous-flow system consisting
of two sequential microreactors
was developed for the synthesis of nonsymmetrically substituted ureas
starting from <i>tert</i>-butoxycarbonyl protected amines.
Short reaction times could be achieved under mild conditions. In-line
FT-IR analytical technique was used to monitor the reaction, including
the formation of the isocyanate intermediate, thus allowing optimization
of the reagent ratios. The mechanistic role of the applied base was
also clarified. The setup was successfully utilized for the synthesis
of several urea derivatives including the active pharmaceutical ingredient
cariprazine