Arcuate nucleus homeostatic systems reflect blood leptin concentration but not feeding behaviour during scheduled feeding on a high-fat diet in mice

Acknowledgements T.B. was funded by a CASE studentship from the BBSRC and AstraZeneca. J.B. was a summer student from Bordeaux Sciences Agro and funded by student laboratory experience grant from the British Society of Neuroendocrinology. The authors are also grateful for funding from the Scottish Government, and from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreements 266408 (Full4Health) and 245009 (NeuroFAST).Peer reviewedPublisher PD

Barriers to recovery and recommendations for change: the Pennsylvania Consensus Conference on psychiatry\u27s role.

OBJECTIVE: Recovery has emerged over the past decade as a dominant theme in public mental health care. METHODS: The 2006 Pennsylvania Consensus Conference brought together 24 community psychiatrists to explore the barriers they experienced in promoting recovery and their recommendations for change. RESULTS: Twelve barriers were identified and classified into one of three categories: psychiatry knowledge, roles, and training; the need to transform public mental health systems and services; and environmental barriers to opportunity. Participants made 22 recommendations to address these barriers through changes in policies, programs, and psychiatric knowledge and practice. CONCLUSIONS: The recommendations identify areas for change that can be accomplished through individual psychiatrist action and organized group efforts

Clinical and financial consequences of setting up an asthma clinic at St. Luke’s Hospital

The effects of setting up an asthma clinic were assessed in an audit study. A comparison was made between the quality and quantity of medication used by patients before and after attending the asthma clinic. The number and severity of exacerbations during a six month period before and a six month period after attending were also assessed. The cost of treatment before and after was also calculated. In 14% of patients, occupational factors, drugs or underlying lung disease were significant contributors to asthma. The number of acute episodes of severe asthma were reduced from 98 to 47, with hospital admissions falling from 26 to 1. Pulmonary function (%FEV1) improved in the group as a whole with the number of patients having their best FEV above 80% improving from 44 to 71. In spite of the expense of high cost drugs and the running costs of the clinic there were substantial savings largely from the reduced number of hospital admissions. The calculated annual cost fell from Lm 22,769 to Lm 10,654.peer-reviewe

Results from a randomized, controlled trial on efficacy and tolerability of a 5% Lidocaine-Medicated Plaster vs. Pregabalin in patients with Post-Herpetic Neuralgia (PHN) and Painful Diabetic Polyneuropathy (DPN) [poster]

No abstract available

Theoretical Clues to the Ultraviolet Diversity of Type Ia Supernovae

The effect of metallicity on the observed light of Type Ia supernovae (SNe Ia) could lead to systematic errors as the absolute magnitudes of local and distant SNe Ia are compared to measure luminosity distances and determine cosmological parameters. The UV light may be especially sensitive to metallicity, though different modeling methods disagree as to the magnitude, wavelength dependence, and even the sign of the effect. The outer density structure, ^56 Ni, and to a lesser degree asphericity, also impact the UV. We compute synthetic photometry of various metallicity-dependent models and compare to UV/optical photometry from the Swift Ultra-Violet/Optical Telescope. We find that the scatter in the mid-UV to near-UV colors is larger than predicted by changes in metallicity alone and is not consistent with reddening. We demonstrate that a recently employed method to determine relative abundances using UV spectra can be done using UVOT photometry, but we warn that accurate results require an accurate model of the cause of the variations. The abundance of UV photometry now available should provide constraints on models that typically rely on UV spectroscopy for constraining metallicity, density, and other parameters. Nevertheless, UV spectroscopy for a variety of SN explosions is still needed to guide the creation of accurate models. A better understanding of the influences affecting the UV is important for using SNe Ia as cosmological probes, as the UV light may test whether SNe Ia are significantly affected by evolutionary effects.Comment: 10 pages. Submitted to Ap

Detailed Spectral Modeling of a 3-D Pulsating Reverse Detonation Model: Too Much Nickel

We calculate detailed NLTE synthetic spectra of a Pulsating Reverse Detonation (PRD) model, a novel explosion mechanism for Type Ia supernovae. While the hydro models are calculated in 3-D, the spectra use an angle averaged hydro model and thus some of the 3-D details are lost, but the overall average should be a good representation of the average observed spectra. We study the model at 3 epochs: maximum light, seven days prior to maximum light, and 5 days after maximum light. At maximum the defining Si II feature is prominent, but there is also a prominent C II feature, not usually observed in normal SNe Ia near maximum. We compare to the early spectrum of SN 2006D which did show a prominent C II feature, but the fit to the observations is not compelling. Finally we compare to the post-maximum UV+optical spectrum of SN 1992A. With the broad spectral coverage it is clear that the iron-peak elements on the outside of the model push too much flux to the red and thus the particular PRD realizations studied would be intrinsically far redder than observed SNe Ia. We briefly discuss variations that could improve future PRD models.Comment: 15 pages, 4 figures, submitted to Ap

A Study of Compact Radio Sources in Nearby Face-on Spiral Galaxies. II. Multiwavelength Analyses of Sources in M51

We report the analysis of deep radio observations of the interacting galaxy system M51 from the Very Large Array, with the goal of understanding the nature of the population of compact radio sources in nearby spiral galaxies. We detect 107 compact radio sources, 64% of which have optical counterparts in a deep H$\alpha$ Hubble Space Telescope image. Thirteen of the radio sources have X-ray counterparts from a {\em Chandra} observation of M51. We find that six of the associated H$\alpha$ sources are young supernova remnants with resolved shells. Most of the SNRs exhibit steep radio continuum spectral indices onsistent with synchrotron emission. We detect emission from the Type Ic SN 1994I nearly a decade after explosion: the emission ($160\pm22 \mu$Jy beam$^{-1}$ at 20 cm, $46\pm11 \mu$Jy beam$^{-1}$ at 6cm, $\alpha=-1.02\pm0.28$) is consistent with light curve models for Type Ib/Ic supernovae. We detect X-ray emission from the supernova, however no optical counterpart is present. We report on the analysis of the Seyfert 2 nucleus in this galaxy, including the evidence for bipolar outflows from the central black hole.Comment: 22 pages, 8 figures (5 color) in separate files, AASTeX. Full resolution figures and preprint may be obtained by contacting [email protected]. AJ accepte

High frequency dynamics in a monatomic glass

The high frequency dynamics of glassy Selenium has been studied by Inelastic X-ray Scattering at beamline BL35XU (SPring-8). The high quality of the data allows one to pinpoint the existence of a dispersing acoustic mode for wavevectors ($Q$) of $1.5<Q<12.5$ nm$^{-1}$, helping to clarify a previous contradiction between experimental and numerical results. The sound velocity shows a positive dispersion, exceeding the hydrodynamic value by $\approx$ 10% at $Q<3.5$ nm$^{-1}$. The $Q^2$ dependence of the sound attenuation $\Gamma(Q)$, reported for other glasses, is found to be the low-$Q$ limit of a more general $\Gamma(Q) \propto \Omega(Q)^2$ law which applies also to the higher $Q$ region, where $\Omega(Q)\propto Q$ no longer holds.Comment: Phys. Rev. Lett. (Accepted