80 research outputs found
Membrane depolarization in PC-12 cells during hypoxia is regulated by an O2-sensitive K+ current
Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription
Mechanism of the Participation of Water in the Decomposition of Hydrogen Trioxide (HOOOH). A Theoretical Study
Purification and partial characterization of a Nocardia brasiliensis extracellular protease
Direct evidence for base-mediated decomposition of alkyl hydroperoxides (ROOH) in the gas phase
Alkyl hydroperoxides (ROOH) are attributed a key role in the biochemical oxidation of lipids during oxidative stress.1 In this chemistry ROOH compounds, where the R groups are unsaturated fatty acids, are viewed as transient ntermediates which are readily degraded, due to the lability of the RO-OH bond, to yield potentially genotoxic aldehydes and ketones.2 Generally, the decomposition of alkyl hydroperoxides is thought to be mediated by radical abstraction or electron transfer processes usually involving enzymes, transition metals, or recently, Vitamin C.3 In this paper we present the first unambiguous experimental and computational evidence for base-mediated heterolytic decomposition of simple alkyl hydroperoxides by the mechanism outlined in Scheme 1
The mutation DGT1-1 decreases glucose transport and alleviates carbon catabolite repression in Saccharomyces cerevisiae
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