Feasibility of three-dimensional reconstruction and automated measurement of fetal long bones using 5D Long Bone™

의과대학/석사Objective: To evaluate the feasibility of 5D Long Bone™ (5D LB™), a new technique that automatically archives, reconstructs images, and measures lengths of fetal long bones, to assess whether the direction of volume sweep influences fetal long bone measurements in three-dimensional (3D) ultrasound and 5D LB™, and to compare measurements of fetal long bone lengths obtained with 5D LB™ and those obtained with conventional two-dimensional (2D) and manual 3D techniques. Methods: This prospective study included 39 singleton pregnancies at 26+0 to 32+0 weeks of gestation. Multiple pregnancies, fetuses with multiple congenital anomalies, and mothers with underlying medical diseases were excluded. Fetal long bones of the lower extremities―the femur, tibia, and fibula were measured by 2D and 3D ultrasound, and 5D LB™, by an expert and non-expert examiner. First, we analyzed the 3D ultrasound and 5D LB™ data according to 2 different sweeping angles. We analyzed intra- and interobserver variability and agreement between ultrasound techniques. Paired t-test, interclass correlation coefficient (ICC), Bland-Altman plot and Passing-Bablok regression were used for statistical analysis. Results: There was no statistical difference between long bone measurements analyzed according to 2 different volume-sweeping angles by 3D ultrasound and 5D LB™. Intra- and interobserver variability were not significantly different among all 3 ultrasound techniques. Comparing 2D ultrasound and 5D LB™, the ICC for femur, tibia, and fibula was 0.91, 0.92, and 0.89, respectively. Conclusion: 5D LB™ is reproducible and comparable with conventional 2D and 3D ultrasound techniques for fetal long bone measurement.ope

Prenatal sonographic detection of congenital perineal Lipoma in a newborn girl

We report on a newborn girl presenting with a 2.0×1.5 cm sized pinkish, doughy lump arising between right labia majora and anus. We performed antenatal sonogram at 33 and 36th weeks gestation. A polypoid mass of 0.8×1.0 cm sized in size was noted on ultrasonography. After birth, we observed a skin-covered protruding mass not to detect other anatomic anomalies-spinal anomalies, anorectal malformations, etc. After 3 months, excision of the perineal mass was done at the Department of Pediatric Surgery of our hospital. Mature fat cells were noted on histopathological exam. To our knowledge, there are few studies in the English literatures about congenital perineal lipoma without combined structural anomaliesope

Feasibility of three-dimensional reconstruction and automated measurement of fetal long bones using 5D Long Bone

OBJECTIVE: To evaluate the feasibility of five-dimensional Long Bone (5D LB), a new technique that automatically archives, reconstructs images, and measures lengths of fetal long bones, to assess whether the direction of volume sweep influences fetal long bone measurements in three-dimensional (3D) ultrasound and 5D LB, and to compare measurements of fetal long bone lengths obtained with 5D LB and those obtained with conventional two-dimensional (2D) and manual 3D techniques. METHODS: This prospective study included 39 singleton pregnancies at 26+0 to 32+0 weeks of gestation. Multiple pregnancies, fetuses with multiple congenital anomalies, and mothers with underlying medical diseases were excluded. Fetal long bones of the lower extremities-the femur, tibia, and fibula were measured by 2D and 3D ultrasound, and 5D LB, by an expert and non-expert examiner. First, we analyzed the 3D ultrasound and 5D LB data according to 2 different sweeping angles. We analyzed intra- and inter-observer variability and agreement between ultrasound techniques. Paired t-test, interclass correlation coefficient, and Bland-Altman plot and Passing-Bablok regression were used for statistical analysis. RESULTS: There was no statistical difference between long bone measurements analyzed according to 2 different volume-sweeping angles by 3D ultrasound and 5D LB. Intra- and inter-observer variability were not significantly different among all 3 ultrasound techniques. Comparing 2D ultrasound and 5D LB, the interclass correlation coefficient for femur, tibia, and fibula was 0.91, 0.92, and 0.89, respectively. CONCLUSION: 5D LB is reproducible and comparable with conventional 2D and 3D ultrasound techniques for fetal long bone measurement.ope

Perioperative and long-term complications among obese women undergoing vaginal surgery

OBJECTIVE: To determine whether obesity influenced the risk of perioperative and long-term complications in patients undergoing vaginal surgery. METHODS: Women diagnosed with pelvic organ prolapse who underwent vaginal surgery between March 1999 and May 2007 were classified into 3 groups: normal weight (body mass index [BMI, calculated as weight in kilograms divided by the square of height in meters] 18.5-23.0); overweight (BMI 23.0-27.5); and obese (BMI >or=27.5). Complications were subdivided into perioperative (or=1 month). Statistical analysis was performed using analysis of variance, chi(2) test, and logistic regression. RESULTS: Demographic information showed no differences among the groups, except for the presence of comorbidity (P=0.03). Blood loss and transfusion as a perioperative complication and urinary retention as a long-term complication were significantly different among the groups: odds ratio (OR) 2.46 (95% confidence interval [CI], 1.38-4.39; P<0.01); and OR 2.20 (95% CI, 1.21-4.03; P=0.03), respectively. CONCLUSION: Major complications were rare, and most were not significantly different among the groups. However, obesity was a protective factor against blood loss and transfusion, and long-term urinary retentionope

Microarray Analysis of the Gene Expression Profilling in the Cytotrophoblasts on Nicotine Exposure

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